(Q33860827)

29 July 2017

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title

Signal transduction in mammary tumorigenesis: a transgenic perspective (English)

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29 July 2017

Dankort DL

1

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29 July 2017

Muller WJ

series ordinal

2

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29 July 2017

language of work or name

English

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publication date

1 February 2000

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29 July 2017

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29 July 2017

19

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29 July 2017

8

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29 July 2017

1038-1044

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1203272

29 July 2017

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cites work

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Ha-ras oncogene expression directed by a milk protein gene promoter: tissue specificity, hormonal regulation, and tumor induction in transgenic mice

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Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c-neu oncogene

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Heregulin stimulates mitogenesis and phosphatidylinositol 3-kinase in mouse fibroblasts transfected with erbB2/neu and erbB3.

21 January 2018

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Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2

21 January 2018

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Transformation by polyoma virus is drastically reduced by substitution of phenylalanine for tyrosine at residue 315 of middle-sized tumor antigen

21 January 2018

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Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation.

21 January 2018

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Polyoma virus transforming protein associates with the product of the c-src cellular gene

21 January 2018

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Distinct tyrosine autophosphorylation sites negatively and positively modulate neu-mediated transformation

21 January 2018

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Transformation by polyoma virus middle T-antigen involves the binding and tyrosine phosphorylation of Shc.

21 January 2018

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Characterization of a neu/c-erbB-2 protein-specific activating factor

21 January 2018

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Association of signaling proteins with a nonmitogenic heterodimeric complex composed of epidermal growth factor receptor and kinase-inactive p185c-neu

21 January 2018

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Regulation of neuronal survival by the serine-threonine protein kinase Akt

21 January 2018

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Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

21 January 2018

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The erbB-2 mitogenic signaling pathway: tyrosine phosphorylation of phospholipase C-gamma and GTPase-activating protein does not correlate with erbB-2 mitogenic potency

21 January 2018

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A genetic model for colorectal tumorigenesis

21 January 2018

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CDC25 phosphatases as potential human oncogenes

21 January 2018

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Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

21 January 2018

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Value of epidermal growth factor receptor status compared with growth fraction and other factors for prognosis in early breast cancer

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Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation

21 January 2018

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Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease

21 January 2018

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Activated neu induces rapid tumor progression.

21 January 2018

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Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease

21 January 2018

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Dimerization of cell surface receptors in signal transduction

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

Interrupting the early region of polyoma virus DNA enhances tumorigenicity

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

Signal transduction from multiple Ras effectors

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

21 January 2018

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Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

21 January 2018

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Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

21 January 2018

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Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

21 January 2018

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Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

Characterization of a growth factor that binds exclusively to the erbB-2 receptor and induces cellular responses

21 January 2018

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Involvement of pp60c-src with two major signaling pathways in human breast cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

Augmented mitogenic responsiveness to epidermal growth factor in murine fibroblasts that overexpress pp60c-src

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

Potentiation of epidermal growth factor receptor-mediated oncogenesis by c-Src: implications for the etiology of multiple human cancers

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

Carboxyl-terminal deletion and point mutations decrease the transforming potential of the activated rat neu oncogene product

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

Synergistic interaction of the Neu proto-oncogene product and transforming growth factor alpha in the mammary epithelium of transgenic mice

21 January 2018

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Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

Heterogeneity of intraductal carcinoma of the breast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

Signaling through scaffold, anchoring, and adaptor proteins

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

The c-erbB-2 proto-oncogene as a prognostic and predictive marker in breast cancer: a paradigm for the development of other macromolecular markers--a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

Epidermal growth factor receptor status of histological sub-types of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

Ligand and p185c-neu density govern receptor interactions and tyrosine kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

Determination of absolute amounts of GDP and GTP bound to Ras in mammalian cells: comparison of parental and Ras-overproducing NIH 3T3 fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

The product of the EMS1 gene, amplified and overexpressed in human carcinomas, is homologous to a v-src substrate and is located in cell-substratum contact sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

Novel activating mutations in the neu proto-oncogene involved in induction of mammary tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

An activated allele of the c-erbB-2 oncogene impairs kidney and lung function and causes early death of transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

From Src Homology domains to other signaling modules: proposal of the 'protein recognition code'.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

A conserved amino-terminal Shc domain binds to phosphotyrosine motifs in activated receptors and phosphopeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

The multistep nature of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

Induction of mammary epithelial hyperplasias and mammary tumors in transgenic mice expressing a murine mammary tumor virus/activated c-src fusion gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

Requirement for both Shc and phosphatidylinositol 3' kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

Cyclin D1 protein expression and function in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

Association of the polyomavirus middle-T antigen with c-yes protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

neu/erbB-2 amplification identifies a poor-prognosis group of women with node-negative breast cancer. Toronto Breast Cancer Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

7 January 2021

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

7 January 2021

Peptide antibodies to the human c-fyn gene product demonstrate pp59c-fyn is capable of complex formation with the middle-T antigen of polyomavirus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

7 January 2021

Risk factors for breast cancer in women with proliferative breast disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

7 January 2021

Activation of the c-Src tyrosine kinase is required for the induction of mammary tumors in transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

7 January 2021

The biology of erbB-2/neu/HER-2 and its role in cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

7 January 2021

Mechanisms of transformation by polyoma virus middle T antigen

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

7 January 2021

Early and multifocal tumors in breast, salivary, Harderian and epididymal tissues developed in MMTY-Neu transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

7 January 2021

Prognostic factors in early breast carcinoma.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

7 January 2021

Site-directed mutagenesis of polyomavirus middle-T antigen sequences encoding tyrosine 315 and tyrosine 250.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

7 January 2021

Mutants of polyomavirus middle-T antigen

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

7 January 2021

Development of mammary hyperplasia and neoplasia in MMTV-TGF alpha transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

7 January 2021

The genetics of breast cancer.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

7 January 2021

Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

7 January 2021

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

7 January 2021

The ErbB-2/HER2 oncogenic receptor of adenocarcinomas: from orphanhood to multiple stromal ligands

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

7 January 2021

Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

7 January 2021

Alterations of the c-erbB2 gene in human breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203272

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1203272

1 reference

Dimensions Publication ID

29 July 2017

0 references

1 reference