(Q33861397)

29 July 2017

title

Cytoplasmic SET induces tau hyperphosphorylation through a decrease of methylated phosphatase 2A. (English)

1 reference

29 July 2017

author name string

Stéphanie Chasseigneaux

1

1 reference

29 July 2017

Christine Clamagirand

2

1 reference

29 July 2017

Léa Huguet

3

1 reference

29 July 2017

Lucie Gorisse-Hussonnois

4

1 reference

29 July 2017

Christiane Rose

5

1 reference

29 July 2017

Bernadette Allinquant

6

1 reference

29 July 2017

publication date

30 June 2014

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29 July 2017

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29 July 2017

volume

15

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29 July 2017

page(s)

82

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Protein phosphatase 2A is regulated by protein kinase Cα (PKCα)-dependent phosphorylation of its targeting subunit B56α at Ser41.

29 July 2017

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5 July 2018

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The carboxy-terminal fragment of inhibitor-2 of protein phosphatase-2A induces Alzheimer disease pathology and cognitive impairment

5 July 2018

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PAT1 induces cell death signal and SET mislocalization into the cytoplasm by increasing APP/APLP2 at the cell surface

5 July 2018

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Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A.

5 July 2018

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Structural mechanism of demethylation and inactivation of protein phosphatase 2A

5 July 2018

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5 July 2018

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5 July 2018

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The nuclear localization of SET mediated by impalpha3/impbeta attenuates its cytosolic toxicity in neurons.

5 July 2018

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5 July 2018

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Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme

5 July 2018

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5 July 2018

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SET protein (TAF1beta, I2PP2A) is involved in neuronal apoptosis induced by an amyloid precursor protein cytoplasmic subdomain

5 July 2018

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Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer's disease

5 July 2018

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Inhibitors of protein phosphatase-2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau.

5 July 2018

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5 July 2018

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5 July 2018

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Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor

5 July 2018

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The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity

5 July 2018

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Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

5 July 2018

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Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein

5 July 2018

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Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo

5 July 2018

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Novel role for the nuclear phosphoprotein SET in transcriptional activation of P450c17 and initiation of neurosteroidogenesis

5 July 2018

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5 July 2018

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Characterization of mAb AP422, a novel phosphorylation-dependent monoclonal antibody against tau protein.

5 July 2018

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A specific protein carboxyl methylesterase that demethylates phosphoprotein phosphatase 2A in bovine brain

5 July 2018

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The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A

5 July 2018

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The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development

5 July 2018

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5 July 2018

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5 July 2018

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The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo

5 July 2018

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Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4086270

Phosphatase activity toward abnormally phosphorylated tau: decrease in Alzheimer disease brain.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4086270

Methotrexate decreases PP2A methylation and increases tau phosphorylation in neuron

5 July 2018

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https://api.crossref.org/works/10.1186%2F1471-2202-15-82

SET translocation is associated with increase in caspase cleaved amyloid precursor protein in CA1 of Alzheimer and Down syndrome patients.

21 January 2018

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https://api.crossref.org/works/10.1186%2F1471-2202-15-82

Involvement of I2PP2A in the abnormal hyperphosphorylation of tau and its reversal by Memantine

21 January 2018

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https://api.crossref.org/works/10.1186%2F1471-2202-15-82

Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and in Alzheimer's disease.

21 January 2018

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A short cytoplasmic domain of the amyloid precursor protein induces apoptosis in vitro and in vivo.

21 January 2018

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Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease.

21 January 2018

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https://api.crossref.org/works/10.1186%2F1471-2202-15-82

Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1186%2F1471-2202-15-82

Ser9 phosphorylation causes cytoplasmic detention of I2PP2A/SET in Alzheimer disease

21 January 2018

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https://api.crossref.org/works/10.1186%2F1471-2202-15-82

PP2A and Alzheimer disease.

21 January 2018

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https://api.crossref.org/works/10.1186%2F1471-2202-15-82

PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta

21 January 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4086270

Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis.

29 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4086270

Caspase-cleaved amyloid precursor protein in Alzheimer's disease.

29 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4086270

Protein phosphatase 2A is reversibly modified by methyl esterification at its C-terminal leucine residue in bovine brain.

29 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4086270

Expression of protein phosphatases (PP-1, PP-2A, PP-2B and PTP-1B) and protein kinases (MAP kinase and P34cdc2) in the hippocampus of patients with Alzheimer disease and normal aged individuals.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4086270

Asp664 cleavage of amyloid precursor protein induces tau phosphorylation by decreasing protein phosphatase 2A activity

29 October 2018

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12 December 2020

Protection by serine peptidase inhibitors of endogenous cholecystokinin released from brain slices

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12 December 2020

Protein phosphatase 2A catalytic subunit is methyl-esterified at its carboxyl terminus by a novel methyltransferase

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12 December 2020

In vivo phosphorylation sites in fetal and adult rat tau

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12 December 2020

Purification and characterization of two potent heat-stable protein inhibitors of protein phosphatase 2A from bovine kidney

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12 December 2020

Identifiers

DOI

10.1186/1471-2202-15-82

1 reference

Dimensions Publication ID

29 July 2017

1 reference

https://scigraph.springernature.com/pub.10.1186/1471-2202-15-82

9 September 2019

1 reference

29 July 2017

1 reference