(Q33870250)

29 July 2017

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title

Alcoholic liver disease: new insights in pathogenesis lead to new treatments (English)

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29 July 2017

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alcoholic liver disease

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Lieber CS

1

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29 July 2017

publication date

1 January 2000

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29 July 2017

published in

Journal of Hepatology

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29 July 2017

volume

32

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29 July 2017

issue

1 Suppl

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29 July 2017

page(s)

113-128

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Hepatotoxicity of ethanol

29 July 2017

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7 January 2021

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7 January 2021

An experimental model of alcohol feeding and liver injury in the baboon

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7 January 2021

Ethanol oxidation by hepatic microsomes: adaptive increase after ethanol feeding

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7 January 2021

Microsomal ethanol-oxidizing system (MEOS): the first 30 years (1968-1998)--a review

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7 January 2021

Interaction of ethanol with beta-carotene: delayed blood clearance and enhanced hepatotoxicity

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7 January 2021

beta-Carotene beadlets potentiate hepatotoxicity of alcohol

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7 January 2021

Alcohol, vitamin A, and beta-carotene: adverse interactions, including hepatotoxicity and carcinogenicity

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7 January 2021

Pathogenesis of methionine-induced toxicity

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7 January 2021

Free amino acids in liver, plasma, and muscle of patients with cirrhosis of the liver

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7 January 2021

Plasma amino acids in patients with hepatic encephalopathy. Effects of amino acid infusions

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7 January 2021

Free amino acids in plasma and skeletal muscle of patients with liver cirrhosis

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7 January 2021

Rate of Disappearance From Plasma of Intravenously Administered Methionine in Patients With Liver Damage

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7 January 2021

S-adenosyl-L-methionine synthetase and phospholipid methyltransferase are inhibited in human cirrhosis

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7 January 2021

Methionine adenosyltransferase and liver disease: it's all about SAM

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7 January 2021

Regulation by hypoxia of methionine adenosyltransferase activity and gene expression in rat hepatocytes

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7 January 2021

Ethanol-induced changes in methionine metabolism in rat liver

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7 January 2021

S-adenosyl-L-methionine attenuates alcohol-induced liver injury in the baboon

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7 January 2021

Phospholipid Methylation and Biological Signal Transmission

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7 January 2021

Identification and properties of two methyltransferases in conversion of phosphatidylethanolamine to phosphatidylcholine

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7 January 2021

Chronic ethanol consumption alters rat liver plasma membranes and potentiates release of alkaline phosphatase

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7 January 2021

Effect of exogenous S-adenosyl-l-methionine on phosphatidylcholine synthesis by isolated rat hepatocytes

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7 January 2021

Uptake and metabolism of S-adenosyl-L-methionine by isolated rat hepatocytes

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7 January 2021

Rates of oxidation of the methionine and S-adenosylmethionine methyl carbons in isolated rat hepatocytes

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7 January 2021

Uptake of adenosylmethionine and related sulfur compounds by isolated rat liver

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https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Catechol-o-methyltransferase in rat erythrocyte and three other tissues: comparison of biochemical properties after removal of inhibitory calcium

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7 January 2021

A radioenzymatic method for S-adenosyl-L-methionine determination in biological fluids

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7 January 2021

Hepatic Phosphatidylethanolamine Methyltransferase Activity Is Decreased by Ethanol and Increased by Phosphatidylcholine

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7 January 2021

Effect of the variations of S-adenosyl-L-methionine liver content on fat accumulation and ethanol metabolism in ethanol-intoxicated rats

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

S-adenosyl-L-methionine: its effect on aminolevulinate dehydratase and glutathione in acute ethanol intoxication

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Effects of S-adenosylmethionine on lipid peroxidation and liver fibrogenesis in carbon tetrachloride-induced cirrhosis

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

S-adenosylmethionine treatment prevents carbon tetrachloride-induced S-adenosylmethionine synthetase inactivation and attenuates liver injury

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Specific loss of the high-molecular-weight form of S-adenosyl-L-methionine synthetase in human liver cirrhosis

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Protective effect of S-adenosyl-l-methionine on liver damage induced by biliary obstruction in rats: a histological, ultrastructural and biochemical approach

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

S-adenosylmethionine prevents total parenteral nutrition-induced cholestasis in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Reversal of intrahepatic cholestasis of pregnancy in women after high dose S-adenosyl-L-methionine administration

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Oral S-adenosylmethionine in the symptomatic treatment of intrahepatic cholestasis. A double-blind, placebo-controlled study

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Effects of oral S-adenosyl-L-methionine on hepatic glutathione in patients with liver disease

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Attenuation of alcohol-induced hepatic fibrosis by polyunsaturated lecithin

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Phosphatidylcholine protects against fibrosis and cirrhosis in the baboon

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Dietary linoleic acid is required for development of experimentally induced alcoholic liver injury

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Acetaldehyde and alcoholic fibrogenesis: fuel to the fire, but not the spark

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https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Hepatic prolyl hydroxylase and collagen synthesis in patients with alcoholic liver disease

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Increased type I procollagen mRNA levels and in vitro protein synthesis in the baboon model of chronic alcoholic liver disease

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Lipocytes and transitional cells in alcoholic liver disease: A morphometric study

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Dilinoleoylphosphatidylcholine decreases hepatic stellate cell activation

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Biochemical and morphological alterations of baboon hepatic mitochondria after chronic ethanol consumption

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Decreased cytochrome oxidase activity in hepatic mitochondria after chronic ethanol consumption and the possible role of decreased cytochrome aa3 content and changes in phospholipids

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Polyenylphosphatidylcholine attenuates alcohol-induced fatty liver and hyperlipemia in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Polyenylphosphatidylcholine attenuates non-alcoholic hepatic fibrosis and accelerates its regression.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Polyunsaturated lecithin prevents acetaldehyde-mediated hepatic collagen accumulation by stimulating collagenase activity in cultured lipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Polyenylphosphatidylcholine prevents carbon tetrachloride-induced lipid peroxidation while it attenuates liver fibrosis

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Use of polyunsaturated phosphatidyl choline in HBsAg negative chronic active hepatitis: results of prospective double-blind controlled trial

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Perivenular fibrosis as precursor lesion of cirrhosis

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Microsomal ethanol-oxidizing system (MEOS): purification and properties of a rat liver system free of catalase and alcohol dehydrogenase

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Hepatic microsomal ethanol-oxidizing system: solubilization, isolation, and characterization

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

The direct oxidation of ethanol by a catalase- and alcohol dehydrogenase-free reconstituted system containing cytochrome P-450

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Purification and characterization of human liver cytochrome P-450-ALC

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

The intralobular distribution of ethanol-inducible P450IIE1 in rat and human liver

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Effect of chronic ethanol administration on bromobenzene liver toxicity in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Influence of alcohol, dithiocarb and (+)-catechin on the hepatotoxicity and metabolism of vinylidene chloride in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Interaction of ethanol with enflurane metabolism and toxicity: role of P450IIE1.

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https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Potentiation of halothane hepatotoxicity by chronic ethanol administration in rat: an animal model of halothane hepatitis

1 reference

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7 January 2021

Acetaminophen activation by human liver cytochromes P450IIE1 and P450IA2

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https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Acetaminophen hepatotoxicity

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7 January 2021

Acetaminophen hepatotoxicity in alcoholics. A therapeutic misadventure

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Association of acetaminophen hepatotoxicity with fasting and ethanol use.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Implication of free radical mechanisms in ethanol-induced cellular injury

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Reduced nicotinamide-adenine dinucleotide phosphate oxidase: activity enhanced by ethanol consumption

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Stable expression of human cytochrome P4502E1 in HepG2 cells: characterization of catalytic activities and production of reactive oxygen intermediates

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Rat liver microsomal NADPH-supported oxidase activity and lipid peroxidation dependent on ethanol-inducible cytochrome P-450 (P-450IIE1)

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Role of cytochrome P-450 2E1 in ethanol-, carbon tetrachloride- and iron-dependent microsomal lipid peroxidation

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Free radical metabolism of alcohols by rat liver microsomes

1 reference

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7 January 2021

Reactive free radical generation in vivo in heart and liver of ethanol-fed rats: correlation with radical formation in vitro

1 reference

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7 January 2021

Spin-trapping studies of hepatic free radicals formed following the acute administration of ethanol to rats: in vivo detection of 1-hydroxyethyl radicals with PBN.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Induction of cytochrome P-4502E1 by ethanol in rat Kupffer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Increase of ethanol, meprobamate and pentobarbital metabolism after chronic ethanol administration in man and in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Effects of ethanol and phenobarbital on the metabolism of propranolol by 9000 g rat liver supernatant

1 reference

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7 January 2021

Propranolol and sotalol metabolism after a drinking party

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Alcohol‐Drugs Interaction in Man: Alcohol and Tolbutamide*

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Increased Rate of Clearance of Drugs from the Circulation of Alcoholics*

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Human and Animal Study on Elimination from Plasma and Metabolism of Diazepam after Chronic Alcohol Intake

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Cytochrome P-4502E1: its physiological and pathological role

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Chlormethiazole inhibition of cytochrome P450 2E1 as assessed by chlorzoxazone hydroxylation in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Zonated expression of cytokines in rat liver: effect of chronic ethanol and the cytochrome P450 2E1 inhibitor, chlormethiazole

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Inhibition of CYP2E1 by chlormethiazole as measured by chlorzoxazone pharmacokinetics in patients with alcoholism and in healthy volunteers

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Lipid peroxidation, CYP2E1 and arachidonic acid metabolism in alcoholic liver disease in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Inhibition of cytochrome P450 2E1 expression by 2-(allylthio)pyrazine, a potential chemoprotective agent: hepatoprotective effects

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Role of cytochrome P4502E1 in alcoholic liver disease pathogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Selective inhibition of cytochrome P450 2E1 in vivo and in vitro with trans-1,2-dichloroethylene

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Polyenylphosphatidylcholine decreases alcoholic hyperlipemia without affecting the alcohol-induced rise of HDL-cholesterol

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Ethanol-induced hyperuricemia: evidence for increased urate production by activation of adenine nucleotide turnover

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

The effect of ethanol on fatty acid metabolism; stimulation of hepatic fatty acid synthesis in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

High-level expression of rat class I alcohol dehydrogenase is sufficient for ethanol-induced fat accumulation in transduced HeLa cells

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Factors that modify the metabolism of ethanol in rat liver and adaptive changes produced by its chronic administration

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Experimental alcohol-induced hepatic necrosis: suppression by propylthiouracil

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

The hepatic blood flow and splanchnic oxygen consumption in alcoholic fatty liver

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Mechanism for selective perivenular hepatotoxicity of ethanol

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Increased Hepatic Oxygenation following Ethanol Administration in the Baboon

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

THE EFFECT OF ETHANOL UPON SYSTEMIC AND HEPATIC BLOOD FLOW IN MAN

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Ethanol-induced increase in portal hepatic blood flow: interference by anesthetic agents.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Impaired oxygen utilization. A new mechanism for the hepatotoxicity of ethanol in sub-human primates

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Dependence of ethanol-induced redox shift on hepatic oxygen tensions prevailing in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Role of xanthine oxidase in ethanol-induced lipid peroxidation in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Role of dietary, adipose, and endogenously synthesized fatty acids in the pathogenesis of the alcoholic fatty liver

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Effects of prolonged ethanol intake in man: role of dietary adipose, and endogenously synthesized fatty acids in the pathogenesis of the alcoholic fatty liver

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Dilinoleoylphosphatidylcholine selectively modulates lipopolysaccharide-induced Kupffer cell activation

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Hepatitis C and alcohol

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Role of alcohol in the progression of liver disease caused by hepatitis C virus infection

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Effect of alcohol consumption on serum hepatitis C virus RNA and histological lesions in chronic hepatitis C.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Impact of alcohol on the histological and clinical progression of hepatitis C infection.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Independent and combined action of hepatitis C virus infection and alcohol consumption on the risk of symptomatic liver cirrhosis

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Relative risk for the development of hepatocellular carcinoma in alcoholic patients with cirrhosis: a multiple logistic-regression coefficient analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

A role for cytokines as regulators of hepatic fibrogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Prevention of carbon tetrachloride-induced rat liver injury by soluble tumor necrosis factor receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Methylprednisolone therapy in patients with severe alcoholic hepatitis. A randomized multicenter trial

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

A randomized trial of prednisolone in patients with severe alcoholic hepatitis

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Short-term and long-term survival in patients with alcoholic hepatitis treated with oxandrolone and prednisolone

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Colchicine in the treatment of cirrhosis of the liver.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Is colchicine effective therapy for cirrhosis?

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Liver transplantation in patients with alcoholic cirrhosis: selection criteria and rates of survival and relapse

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Selection for and outcome of liver transplantation in alcoholic liver disease

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Liver transplantation for alcoholic liver disease: survival of patients transplanted with alcoholic hepatitis plus cirrhosis as compared with those with cirrhosis alone.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Naltrexone and coping skills therapy for alcohol dependence. A controlled study

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

Naltrexone in the treatment of alcohol dependence

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2800%2980420-1

7 January 2021

10.1016/S0168-8278(00)80420-1

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DOI

1 reference

29 July 2017

1 reference