(Q33870433)

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Pre-clinical properties of the alpha4beta2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence

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Europe PubMed Central

PubMed publication ID

29 July 2017

Pre-clinical properties of the alpha4beta2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence (English)

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

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nicotine dependence

1 reference

based on heuristic

inferred from title

1 reference

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author name string

H Rollema

1

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

A Shrikhande

2

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

K M Ward

3

1 reference

Europe PubMed Central

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29 July 2017

F D Tingley

4

1 reference

Europe PubMed Central

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29 July 2017

J W Coe

5

1 reference

Europe PubMed Central

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29 July 2017

B T O'Neill

6

1 reference

Europe PubMed Central

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29 July 2017

E Tseng

7

1 reference

Europe PubMed Central

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29 July 2017

E Q Wang

8

1 reference

Europe PubMed Central

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29 July 2017

R J Mather

9

1 reference

Europe PubMed Central

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29 July 2017

R S Hurst

10

1 reference

Europe PubMed Central

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29 July 2017

K E Williams

11

1 reference

Europe PubMed Central

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29 July 2017

M de Vries

12

1 reference

Europe PubMed Central

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29 July 2017

T Cremers

13

1 reference

Europe PubMed Central

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29 July 2017

S Bertrand

14

1 reference

Europe PubMed Central

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29 July 2017

D Bertrand

15

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Europe PubMed Central

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29 July 2017

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publication date

22 March 2010

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Europe PubMed Central

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29 July 2017

British Journal of Pharmacology

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29 July 2017

160

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Europe PubMed Central

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29 July 2017

2

1 reference

Europe PubMed Central

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29 July 2017

334-345

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Nicotinic receptors in the habenulo-interpeduncular system are necessary for nicotine withdrawal in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874855

5 July 2018

Rodent habenulo-interpeduncular pathway expresses a large variety of uncommon nAChR subtypes, but only the alpha3beta4* and alpha3beta3beta4* subtypes mediate acetylcholine release

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874855

5 July 2018

alpha7 and non-alpha7 nicotinic acetylcholine receptors modulate dopamine release in vitro and in vivo in the rat prefrontal cortex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874855

5 July 2018

Crucial role of alpha4 and alpha6 nicotinic acetylcholine receptor subunits from ventral tegmental area in systemic nicotine self-administration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874855

5 July 2018

In vivo activation of midbrain dopamine neurons via sensitized, high-affinity alpha 6 nicotinic acetylcholine receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874855

5 July 2018

Pharmacology of nicotine: addiction, smoking-induced disease, and therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874855

5 July 2018

Nicotine receptor partial agonists for smoking cessation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874855

5 July 2018

Human nocturnal frontal lobe epilepsy: pharmocogenomic profiles of pathogenic nicotinic acetylcholine receptor beta-subunit mutations outside the ion channel pore

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874855

5 July 2018

It is not "either/or": activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874855

5 July 2018

Alpha6-containing nicotinic acetylcholine receptors dominate the nicotine control of dopamine neurotransmission in nucleus accumbens.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874855

5 July 2018

Rationale, pharmacology and clinical efficacy of partial agonists of alpha4beta2 nACh receptors for smoking cessation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874855

5 July 2018

Cytisine for the treatment of nicotine addiction: from a molecule to therapeutic efficacy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874855

5 July 2018

Pharmacological profile of the alpha4beta2 nicotinic acetylcholine receptor partial agonist varenicline, an effective smoking cessation aid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874855

5 July 2018

Partial agonists as therapeutic agents at neuronal nicotinic acetylcholine receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874855

5 July 2018

Cytisine for smoking cessation: a literature review and a meta-analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874855

5 July 2018

Varenicline is a partial agonist at alpha4beta2 and a full agonist at alpha7 neuronal nicotinic receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874855

5 July 2018

Neuropharmacology and potential efficacy of new treatments for tobacco dependence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874855

5 July 2018

Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874855

5 July 2018

Nicotinic acetylcholine receptors as drug targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874855

5 July 2018

The neurobiology of nicotine addiction: bridging the gap from molecules to behaviour

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874855

5 July 2018

Effects of nicotine in the dopaminergic system of mice lacking the alpha4 subunit of neuronal nicotinic acetylcholine receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874855

5 July 2018

SSR591813, a novel selective and partial alpha4beta2 nicotinic receptor agonist with potential as an aid to smoking cessation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874855

5 July 2018

Cellular and synaptic mechanisms of nicotine addiction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874855

5 July 2018

Chronic exposure to nicotine upregulates the human (alpha)4((beta)2 nicotinic acetylcholine receptor function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874855

5 July 2018

Activation and inhibition of the human alpha7 nicotinic acetylcholine receptor by agonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874855

5 July 2018

Acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874855

5 July 2018

Partial agonist properties of cytisine on neuronal nicotinic receptors containing the beta 2 subunit.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874855

5 July 2018

Behavioural and pharmacokinetic studies on nicotine, cytisine and lobeline

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874855

5 July 2018

Quantitative microdialysis using modified ultraslow microdialysis: direct rapid and reliable determination of free brain concentrations with the MetaQuant technique.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2010.00682.X

21 January 2018

Influence of nonspecific brain and plasma binding on CNS exposure: implications for rational drug discovery

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2010.00682.X

21 January 2018

Synaptic mechanisms underlie nicotine-induced excitability of brain reward areas

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2010.00682.X

21 January 2018

Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2010.00682.X

21 January 2018

Arterial nicotine kinetics during cigarette smoking and intravenous nicotine administration: implications for addiction.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2010.00682.X

21 January 2018

Ligands selective for alpha4beta2 but not alpha3beta4 or alpha7 nicotinic receptors generalise to the nicotine discriminative stimulus in the rat.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2010.00682.X

21 January 2018

Guide to Receptors and Channels (GRAC), 4th Edition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874855

29 October 2018

Varenicline versus bupropion SR or placebo for smoking cessation: a pooled analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874855

29 October 2018

Single-dose pharmacokinetics of varenicline, a selective nicotinic receptor partial agonist, in healthy smokers and nonsmokers

1 reference

https://pubmed.ncbi.nlm.nih.gov/20331614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics, safety, and tolerability after single and multiple oral doses of varenicline in elderly smokers

1 reference

https://pubmed.ncbi.nlm.nih.gov/20331614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple-dose pharmacokinetics of the selective nicotinic receptor partial agonist, varenicline, in healthy smokers

1 reference

https://pubmed.ncbi.nlm.nih.gov/20331614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of human pharmacokinetics from preclinical information: comparative accuracy of quantitative prediction approaches

1 reference

https://pubmed.ncbi.nlm.nih.gov/20331614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of ezlopitant, a novel non-peptidic neurokinin-1 receptor antagonist in preclinical species and metabolite kinetics of the pharmacologically active metabolites

1 reference

https://pubmed.ncbi.nlm.nih.gov/20331614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1476-5381.2010.00682.X

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

ResearchGate publication ID

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