(Q33883203)

English

Discovery of the selective androgen receptor modulator MK-0773 using a rational development strategy based on differential transcriptional requirements for androgenic anabolism versus reproductive physiology

scientific article

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Discovery of the selective androgen receptor modulator MK-0773 using a rational development strategy based on differential transcriptional requirements for androgenic anabolism versus reproductive physiology (English)

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

author name string

Azriel Schmidt

1

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Donald B Kimmel

2

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Chang Bai

3

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Angela Scafonas

4

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Sujane Rutledge

5

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Robert L Vogel

6

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Sheila McElwee-Witmer

7

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Fang Chen

8

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Pascale V Nantermet

9

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Viera Kasparcova

10

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Chih-Tai Leu

11

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Hai-Zhuan Zhang

12

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Mark E Duggan

13

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Michael A Gentile

14

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Paul Hodor

15

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Brenda Pennypacker

16

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Patricia Masarachia

17

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Evan E Opas

18

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Sharon A Adamski

19

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Tara E Cusick

20

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Jiabing Wang

21

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Helen J Mitchell

22

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Yuntae Kim

23

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Thomayant Prueksaritanont

24

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

James J Perkins

25

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Robert S Meissner

26

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

George D Hartman

27

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Leonard P Freedman

28

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Shun-ichi Harada

29

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

William J Ray

30

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

language of work or name

0 references

publication date

31 March 2010

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

285

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

22

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

17054-17064

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Identification of anabolic selective androgen receptor modulators with reduced activities in reproductive tissues and sebaceous glands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878020

5 July 2018

Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878020

5 July 2018

Influence of testosterone and a novel SARM on gene expression in whole blood of Macaca fascicularis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878020

5 July 2018

Mechanism of androgen receptor action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878020

5 July 2018

Selective androgen receptor modulators as function promoting therapies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878020

5 July 2018

Selective androgen receptor modulators in preclinical and clinical development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878020

5 July 2018

Testosterone in obesity, metabolic syndrome and type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878020

5 July 2018

The contribution of different androgen receptor domains to receptor dimerization and signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878020

5 July 2018

A selective androgen receptor modulator with minimal prostate hypertrophic activity enhances lean body mass in male rats and stimulates sexual behavior in female rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878020

5 July 2018

Thematic review series: skin lipids. Sebaceous gland lipids: friend or foe?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878020

5 July 2018

Modulation of Androgen Receptor Activation Function 2 by Testosterone and Dihydrotestosterone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878020

5 July 2018

Synthesis and SAR of tetrahydropyrrolo[1,2-b][1,2,5]thiadiazol-2(3H)-one 1,1-dioxide analogues as highly potent selective androgen receptor modulators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878020

5 July 2018

Safety of testosterone treatment in postmenopausal women

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878020

5 July 2018

An orally active selective androgen receptor modulator is efficacious on bone, muscle, and sex function with reduced impact on prostate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878020

5 July 2018

Effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes: the NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878020

5 July 2018

Androgens, cardiovascular disease and osteoporosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878020

5 July 2018

Therapeutic potential of the SARMs: revisiting the androgen receptor for drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878020

5 July 2018

Ligand-specific allosteric regulation of coactivator functions of androgen receptor in prostate cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878020

5 July 2018

Interaction between the androgen receptor and RNase L mediates a cross-talk between the interferon and androgen signaling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878020

5 July 2018

Selective androgen receptor modulator treatment improves muscle strength and body composition and prevents bone loss in orchidectomized rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878020

5 July 2018

Roles of steroid receptor coactivator (SRC)-1 and transcriptional intermediary factor (TIF) 2 in androgen receptor activity in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878020

5 July 2018

Partial agonist/antagonist properties of androstenedione and 4-androsten-3beta,17beta-diol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878020

5 July 2018

Comparison of the pharmacological effects of a novel selective androgen receptor modulator, the 5alpha-reductase inhibitor finasteride, and the antiandrogen hydroxyflutamide in intact rats: new approach for benign prostate hyperplasia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878020

5 July 2018

A ligand-based approach to identify quantitative structure-activity relationships for the androgen receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878020

5 July 2018

Regulation of body composition by androgens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878020

5 July 2018

Testosterone supplementation for aging-associated sarcopenia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878020

5 July 2018

The effect of androgen supplementation therapy on the prostate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878020

5 July 2018

Bone Anabolic Effects of S-40503, a Novel Nonsteroidal Selective Androgen Receptor Modulator (SARM), in Rat Models of Osteoporosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878020

5 July 2018

Identification of genetic pathways activated by the androgen receptor during the induction of proliferation in the ventral prostate gland.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878020

5 July 2018

Scd3--a novel gene of the stearoyl-CoA desaturase family with restricted expression in skin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878020

5 July 2018

Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878020

5 July 2018

Nuclear receptor/AP-1 interaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878020

5 July 2018

MDA-MB-453, an androgen-responsive human breast carcinoma cell line with high level androgen receptor expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878020

5 July 2018

Androgen receptor antagonist versus agonist activities of the fungicide vinclozolin relative to hydroxyflutamide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878020

5 July 2018

Androgen receptor-mediated transcriptional regulation in the absence of direct interaction with a specific DNA element

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878020

5 July 2018

Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878020

5 July 2018

A selective androgen receptor modulator with minimal prostate hypertrophic activity restores lean body mass in aged orchidectomized male rats.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.099002

21 January 2018

Partial androgen insensitivity with phenotypic variation caused by androgen receptor mutations that disrupt activation function 2 and the NH(2)- and carboxyl-terminal interaction.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.099002

21 January 2018

Gene expression analyses in cynomolgus monkeys provides mechanistic insight into high-density lipoprotein-cholesterol reduction by androgens in primates.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.099002

21 January 2018

Mutations in the amino-terminal domain of the human androgen receptor may be associated with partial androgen insensitivity and impaired transactivation in vitro.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.099002

21 January 2018

Evaluation of ligand-dependent changes in AR structure using peptide probes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.099002

21 January 2018

Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.099002

21 January 2018

Androgenic induction of growth and differentiation in the rodent uterus involves the modulation of estrogen-regulated genetic pathways.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.099002

21 January 2018

Disrupted amino- and carboxyl-terminal interactions of the androgen receptor are linked to androgen insensitivity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878020

29 October 2018

A New Synthetic Steroid, Osaterone Acetate (TZP-4238), Increases Cortical Bone Mass and Strength by Enhancing Bone Formation in Ovariectomized Rats

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.099002

21 January 2018

A controlled trial of raloxifene (LY139481) HCl: impact on bone turnover and serum lipid profile in healthy postmenopausal women

1 reference

https://pubmed.ncbi.nlm.nih.gov/20356837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intermolecular NH2-/carboxyl-terminal interactions in androgen receptor dimerization revealed by mutations that cause androgen insensitivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20356837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M109.099002

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q33883203&oldid=1533136622"