(Q33885205)

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Serine 129 phosphorylation reduces the ability of alpha-synuclein to regulate tyrosine hydroxylase and protein phosphatase 2A in vitro and in vivo.

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29 January 2020

Serine 129 phosphorylation reduces the ability of alpha-synuclein to regulate tyrosine hydroxylase and protein phosphatase 2A in vitro and in vivo (English)

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29 January 2020

phosphorylation

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based on heuristic

inferred from title

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based on heuristic

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Emily Friedrich

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29 January 2020

Donato A Di Monte

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29 January 2020

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Haiyan Lou

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29 January 2020

Susana E Montoya

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29 January 2020

Tshianda N M Alerte

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29 January 2020

Jian Wang

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29 January 2020

Jianjun Wu

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29 January 2020

Xiangmin Peng

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29 January 2020

Chang-Sook Hong

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29 January 2020

Samantha A Mader

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29 January 2020

Courtney J Pedersen

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29 January 2020

Brian S Marcus

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29 January 2020

Alison L McCormack

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29 January 2020

S Colette Daubner

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29 January 2020

Ruth G Perez

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29 January 2020

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31 March 2010

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29 January 2020

Journal of Biological Chemistry

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29 January 2020

285

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29 January 2020

23

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29 January 2020

17648-17661

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29 January 2020

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11 June 2022

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Enhanced alpha-synuclein expression in human neurodegenerative diseases: pathogenetic and therapeutic implications.

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Emerging pathways in genetic Parkinson's disease: Potential role of ceramide metabolism in Lewy body disease

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5 July 2018

Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system

1 reference

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Pathologic modifications of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated squirrel monkeys

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Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein

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5 July 2018

Silencing alpha-synuclein gene expression enhances tyrosine hydroxylase activity in MN9D cells

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Alpha-synuclein aggregation alters tyrosine hydroxylase phosphorylation and immunoreactivity: lessons from viral transduction of knockout mice

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5 July 2018

The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease

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Reduced vesicular storage of dopamine causes progressive nigrostriatal neurodegeneration

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Protein kinase C delta negatively regulates tyrosine hydroxylase activity and dopamine synthesis by enhancing protein phosphatase-2A activity in dopaminergic neurons

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Chaperone and anti-chaperone: two-faced synuclein as stimulator of synaptic evolution

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Sustained phosphorylation of tyrosine hydroxylase at serine 40: a novel mechanism for maintenance of catecholamine synthesis

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5 July 2018

Alpha-synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells

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Protein phosphatase 2A enhances the proapoptotic function of Bax through dephosphorylation

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Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/threonine phosphatase 2A holoenzymes

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5 July 2018

Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt

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5 July 2018

Alpha-synuclein activation of protein phosphatase 2A reduces tyrosine hydroxylase phosphorylation in dopaminergic cells

1 reference

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5 July 2018

Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells.

1 reference

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5 July 2018

Australian data and meta-analysis lend support for alpha-synuclein (NACP-Rep1) as a risk factor for Parkinson's disease

1 reference

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5 July 2018

Mutation of regulatory serines of rat tyrosine hydroxylase to glutamate: effects on enzyme stability and activity

1 reference

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5 July 2018

Tyrosine hydroxylase phosphorylation: regulation and consequences

1 reference

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5 July 2018

Effects of mutations in tyrosine hydroxylase associated with progressive dystonia on the activity and stability of the protein.

1 reference

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5 July 2018

Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

1 reference

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5 July 2018

Could a loss of alpha-synuclein function put dopaminergic neurons at risk?

1 reference

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5 July 2018

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

1 reference

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5 July 2018

Casein kinase II-mediated phosphorylation regulates alpha-synuclein/synphilin-1 interaction and inclusion body formation

1 reference

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5 July 2018

alpha-Synuclein locus triplication causes Parkinson's disease

1 reference

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5 July 2018

Alpha-synuclein up-regulates expression of caveolin-1 and down-regulates extracellular signal-regulated kinase activity in B103 neuroblastoma cells: role in the pathogenesis of Parkinson's disease

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Co-ordinate transcriptional regulation of dopamine synthesis genes by alpha-synuclein in human neuroblastoma cell lines

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5 July 2018

Attenuation of dopamine transporter activity by alpha-synuclein

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Regulation of telomerase activity and anti-apoptotic function by protein-protein interaction and phosphorylation

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Regulation of tyrosine hydroxylase by stress-activated protein kinases

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Impaired dopamine storage resulting from alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's disease

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A role for alpha-synuclein in the regulation of dopamine biosynthesis

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alpha-Synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney-293 cells

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alpha-Synuclein is phosphorylated in synucleinopathy lesions

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5 July 2018

Depolarization-stimulated catecholamine biosynthesis: involvement of protein kinases and tyrosine hydroxylase phosphorylation sites in situ

1 reference

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5 July 2018

Postnatal expression of alpha-synuclein protein in the rodent substantia nigra and striatum

1 reference

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5 July 2018

alpha-Synuclein forms a complex with transcription factor Elk-1.

1 reference

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5 July 2018

Structural changes in alpha-synuclein affect its chaperone-like activity in vitro

1 reference

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Synucleins are a novel class of substrates for G protein-coupled receptor kinases

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Chaperone-like activity of synucleins

1 reference

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Olfaction in Parkinson's disease: methods of assessment and clinical relevance

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5 July 2018

Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

1 reference

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Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

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Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP.

1 reference

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Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein

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Stimulus-coupled interaction of tyrosine hydroxylase with 14-3-3 proteins.

1 reference

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alpha-Synuclein shares physical and functional homology with 14-3-3 proteins

1 reference

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1 reference

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5 July 2018

Role of serine-19 phosphorylation in regulating tyrosine hydroxylase studied with site- and phosphospecific antibodies and site-directed mutagenesis.

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Expression pattern of synucleins (non-Abeta component of Alzheimer's disease amyloid precursor protein/alpha-synuclein) during murine brain development

1 reference

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5 July 2018

Effects of phosphorylation of serine 40 of tyrosine hydroxylase on binding of catecholamines: evidence for a novel regulatory mechanism

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alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

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5 July 2018

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

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5 July 2018

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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5 July 2018

Intricate regulation of tyrosine hydroxylase activity and gene expression

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5 July 2018

Expression and characterization of catalytic and regulatory domains of rat tyrosine hydroxylase

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5 July 2018

Dephosphorylation of tyrosine hydroxylase by brain protein phosphatases: a predominant role for type 2A.

1 reference

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5 July 2018

Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations

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5 July 2018

Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal

1 reference

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5 July 2018

Molecular cloning of cDNA coding for brain-specific 14-3-3 protein, a protein kinase-dependent activator of tyrosine and tryptophan hydroxylases

1 reference

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5 July 2018

The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells

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5 July 2018

Site-directed mutagenesis of serine 40 of rat tyrosine hydroxylase. Effects of dopamine and cAMP-dependent phosphorylation on enzyme activity

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5 July 2018

ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ

1 reference

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5 July 2018

Regulation and role of brain calcium/calmodulin-dependent protein kinase II.

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5 July 2018

Catecholamine innervation of the basal forebrain. IV. Topography of the dopamine projection to the basal forebrain and neostriatum

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5 July 2018

The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease.

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21 January 2018

Phosphorylation of Ser19 increases both Ser40 phosphorylation and enzyme activity of tyrosine hydroxylase in intact cells.

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21 January 2018

Phosphorylation of tyrosine hydroxylase in isolated mice adrenal glands

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21 January 2018

Role of protein phosphatase 2C from bovine adrenal chromaffin cells in the dephosphorylation of phospho-serine 40 tyrosine hydroxylase

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21 January 2018

Structural and functional implications of C-terminal regions of alpha-synuclein

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21 January 2018

Chaperone-like activities of alpha-synuclein: alpha-synuclein assists enzyme activities of esterases.

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https://api.crossref.org/works/10.1074%2FJBC.M110.100867

21 January 2018

Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.100867

21 January 2018

Accumulation of phosphorylated alpha-synuclein in aging human brain.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.100867

21 January 2018

Tyrosine hydroxylase dephosphorylation by protein phosphatase 2A in bovine adrenal chromaffin cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.100867

21 January 2018

Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.100867

21 January 2018

The specificity of extracellular signal-regulated kinase 2 dephosphorylation by protein phosphatases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.100867

21 January 2018

Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.100867

21 January 2018

Selective hyposmia and nigrostriatal dopaminergic denervation in Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.100867

21 January 2018

Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.100867

21 January 2018

Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.100867

21 January 2018

Interaction of phosphorylated tyrosine hydroxylase with 14-3-3 proteins: evidence for a phosphoserine 40-dependent association

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.100867

21 January 2018

Comparison analysis of distributions of tyrosine hydroxylase, calmodulin and calcium/calmodulin-dependent protein kinase II in a triple stained slice of rat brain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.100867

21 January 2018

Differential expression of the B'beta regulatory subunit of protein phosphatase 2A modulates tyrosine hydroxylase phosphorylation and catecholamine synthesis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.100867

21 January 2018

alpha-Synuclein promoter confers susceptibility to Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.100867

21 January 2018

Aging of the nigrostriatal system in the squirrel monkey

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.100867

21 January 2018

The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: paraquat and alpha-synuclein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.100867

21 January 2018

Alpha-synuclein expression in the substantia nigra of MPTP-lesioned non-human primates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.100867

21 January 2018

Differential gene expression involved in oxidative stress response caused by triethylene glycol dimethacrylate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.100867

21 January 2018

Phosphorylated alpha-synuclein in normal mouse brain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.100867

21 January 2018

Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878529

29 October 2018

Alleviation of catecholamine inhibition of tyrosine hydroxylase by phosphorylation at serine40.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878529

29 October 2018

alpha-synuclein gene haplotypes are associated with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.100867

21 January 2018

Collaborative Analysis of α-Synuclein Gene Promoter Variability and Parkinson Disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.100867

21 January 2018

Identification of protein phosphatase 2A as the major tyrosine hydroxylase phosphatase in adrenal medulla and corpus striatum: evidence from the effects of okadaic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/20356833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

pH-dependent release of catecholamines from tyrosine hydroxylase and the effect of phosphorylation of Ser-40

1 reference

https://pubmed.ncbi.nlm.nih.gov/20356833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation and multiple-site phosphorylation of tyrosine hydroxylase in perfused rat adrenal glands

1 reference

https://pubmed.ncbi.nlm.nih.gov/20356833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha-synuclein: Implication for alpha-synucleinopathies

1 reference

https://pubmed.ncbi.nlm.nih.gov/20356833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42

1 reference

https://pubmed.ncbi.nlm.nih.gov/20356833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stoichiometry of tyrosine hydroxylase phosphorylation in the nigrostriatal and mesolimbic systems in vivo: effects of acute haloperidol and related compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/20356833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of protein kinase C by purified bovine brain 14-3-3: comparison with tyrosine hydroxylase activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20356833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20356833

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M110.100867

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20356833%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

release_uiuy4l5yrfen7c3yd3iddcsd4i

1 reference

https://api.fatcat.wiki/v0/release/uiuy4l5yrfen7c3yd3iddcsd4i

24 November 2022

based on heuristic

mapped directly with Wikidata item

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20356833%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20356833%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

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