(Q33888212)

29 July 2017

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title

Orthotopic metastatic mouse models for anticancer drug discovery and evaluation: a bridge to the clinic (English)

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29 July 2017

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Hoffman RM

1

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29 July 2017

1 January 1999

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Investigational New Drugs

29 July 2017

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29 July 2017

17

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29 July 2017

4

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29 July 2017

343-359

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https://scigraph.springernature.com/pub.10.1023/a:1006326203858

29 July 2017

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cites work

"Seed" to "soil" is a return trip in metastasis.

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12 December 2020

5-FU-induced apoptosis correlates with efficacy against human gastric and colon cancer xenografts in nude mice

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12 December 2020

Antitumor effect of a neutralizing antibody to vascular endothelial growth factor on liver metastasis of endocrine neoplasm.

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12 December 2020

Human ovarian carcinoma metastatic models constructed in nude mice by orthotopic transplantation of histologically-intact patient specimens

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12 December 2020

Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture

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12 December 2020

Orthotopic is orthodox: why are orthotopic-transplant metastatic models different from all other models?

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12 December 2020

Heterotransplantation of a human malignant tumour to "Nude" mice

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12 December 2020

Visualization of the metastatic process by green fluorescent protein expression.

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12 December 2020

Conversion of highly malignant colon cancer from an aggressive to a controlled disease by oral administration of a metalloproteinase inhibitor

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12 December 2020

Extensive multi-organ metastasis following orthotopic onplantation of histologically-intact human bladder carcinoma tissue in nude mice

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12 December 2020

Nude mouse metastatic models of human stomach cancer constructed using orthotopic implantation of histologically intact tissue

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12 December 2020

High-malignancy orthotopic nude mouse model of human prostate cancer LNCaP.

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12 December 2020

Loss of heterozygosity analysis in primary mammary tumors and lung metastases of MMTV-MTAg and MMTV-neu transgenic mice.

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12 December 2020

A patient-like orthotopic implantation nude mouse model of highly metastatic human ovarian cancer

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12 December 2020

A patient-like metastasizing model of human lung adenocarcinoma constructed via thoracotomy in nude mice

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12 December 2020

Carboxymethyl benzylamide dextran blocks angiogenesis of MDA-MB435 breast carcinoma xenografted in fat pad and its lung metastases in nude mice

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12 December 2020

Human tumor bone metastasis model in athymic nude rats

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12 December 2020

Use of histoculture and green fluorescent protein to visualize tumor cell host interaction

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12 December 2020

Electroporation therapy of human larynx tumors HEp-2 implanted in nude mice

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12 December 2020

Green fluorescent protein as a marker for gene expression

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12 December 2020

A fluorescent orthotopic bone metastasis model of human prostate cancer

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12 December 2020

A new patient-like metastatic model of human lung cancer constructed orthotopically with intact tissue via thoracotomy in immunodeficient mice

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12 December 2020

Experimental screening procedures and clinical predictability value

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12 December 2020

Tumorigenicity and metastasis of human breast carcinoma cell lines in nude mice

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12 December 2020

Patient-like nude-mouse and scid-mouse models of human lung and pleural cancer (review).

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12 December 2020

Red-shifted excitation mutants of the green fluorescent protein

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12 December 2020

The LCC15-MB human breast cancer cell line expresses osteopontin and exhibits an invasive and metastatic phenotype

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12 December 2020

Comparison of the inhibitory effect of the angiogenesis inhibitor, TNP-470, and mitomycin C on the growth and liver metastasis of human colon cancer

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12 December 2020

Orthotopic transplantation of histologically intact clinical specimens of stomach cancer to nude mice: correlation of metastatic sites in mouse and individual patient donors

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12 December 2020

Mitomycin C and cisplatin increase survival in a human pancreatic cancer metastatic model

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12 December 2020

Electroporation enhances therapeutic efficacy of anticancer drugs: treatment of human pancreatic tumor in animal model

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12 December 2020

Orthotopic implantation of human prostate cancer cell lines: a clinically relevant animal model for metastatic prostate cancer

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12 December 2020

An ultra-metastatic model of human colon cancer in nude mice

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12 December 2020

Immunochemotherapy prevents human colon cancer metastasis after orthotopic onplantation of histologically-intact tumor tissue in nude mice

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12 December 2020

Postsurgical oral administration of uracil and tegafur inhibits progression of micrometastasis of human breast cancer cells in nude mice.

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12 December 2020

Metastatic human pleural ovarian cancer model constructed by orthotopic implantation of fresh histologically-intact patient carcinoma in nude mice

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12 December 2020

Stimulation of interleukin-11 production from osteoblast-like cells by transforming growth factor-beta and tumor cell factors

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12 December 2020

Widespread skeletal metastatic potential of human lung cancer revealed by green fluorescent protein expression.

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12 December 2020

Surgical orthotopic implantation allows high lung and lymph node metastatic expression of human prostate carcinoma cell line PC-3 in nude mice

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12 December 2020

Stimulation of breast cancer invasion and metastasis by synuclein gamma

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12 December 2020

Clinical course of human epithelial-type malignant pleural mesothelioma replicated in an orthotopic-transplant nude mouse model.

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12 December 2020

Metastatic prostate cancer in a transgenic mouse

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12 December 2020

"Patient-like" nude mouse metastatic model of advanced human pleural cancer

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12 December 2020

Differential chemosensitivity of local and metastatic human gastric cancer after orthotopic transplantation of histologically intact tumor tissue in nude mice

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12 December 2020

A clinical nude mouse metastatic model for highly malignant human pancreatic cancer

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12 December 2020

Interferon gamma is highly effective against orthotopically-implanted human pleural adenocarcinoma in nude mice

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12 December 2020

A model for osseous metastasis of human breast cancer established by intrafemur injection of the MDA-MB-435 cells in nude mice

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12 December 2020

Selection of highly metastatic variants of different human prostatic carcinomas using orthotopic implantation in nude mice

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12 December 2020

Altered establishment/clearance mechanisms during experimental micrometastasis with live and/or disabled bacterial lacZ-tagged tumor cells

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12 December 2020

The invasive and metastatic properties of hormone-independent but hormone-responsive variants of MCF-7 human breast cancer cells.

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12 December 2020

Primary structure of the Aequorea victoria green-fluorescent protein

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12 December 2020

A metastatic and androgen-sensitive human prostate cancer model using intraprostatic inoculation of LNCaP cells in SCID mice.

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12 December 2020

Cellular expression of green fluorescent protein, coupled with high-resolution in vivo videomicroscopy, to monitor steps in tumor metastasis

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12 December 2020

Energy transfer in a bioluminescent system

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12 December 2020

Development of a high metastatic orthotopic model of human renal cell carcinoma in nude mice: benefits of fragment implantation compared to cell-suspension injection

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12 December 2020

Prostate cancer in a transgenic mouse

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12 December 2020

A metastatic nude-mouse model of human pancreatic cancer constructed orthotopically with histologically intact patient specimens

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12 December 2020

Metastatic models of human liver cancer in nude mice orthotopically constructed by using histologically intact patient specimens

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12 December 2020

Improved green fluorescence

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12 December 2020

Effect of angiogenesis inhibitor TNP-470 on the progression of human gastric cancer xenotransplanted into nude mice

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12 December 2020

A new patient-like metastatic model of human small-cell lung cancer constructed orthotopically with intact tissue via thoracotomy in nude mice

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12 December 2020

Parathyroid hormone-related protein and bone metastases

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12 December 2020

FACS-optimized mutants of the green fluorescent protein (GFP)

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12 December 2020

A patient-like human malignant pleural mesothelioma nude-mouse model

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12 December 2020

Smad3 mutant mice develop metastatic colorectal cancer

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12 December 2020

Efficacy of an angiogenesis inhibitor, TNP-470, in xenotransplanted human colorectal cancer with high metastatic potential

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12 December 2020

Orthotopic reconstitution of human small-cell lung carcinoma after intravenous transplantation in SCID mice

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12 December 2020

Site-specific chemosensitivity of human small-cell lung carcinoma growing orthotopically compared to subcutaneously in SCID mice: the importance of orthotopic models to obtain relevant drug evaluation data

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12 December 2020

Early resection of primary orthotopically-growing human colon tumor in nude mouse prevents liver metastasis: further evidence for patient-like hematogenous metastatic route

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12 December 2020

Chemical structure of the hexapeptide chromophore of the Aequorea green-fluorescent protein

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12 December 2020

Metastatic model for human prostate cancer using orthotopic implantation in nude mice

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12 December 2020

A murine model of experimental metastasis to bone and bone marrow.

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12 December 2020

A novel "patient-like" treatment model of human pancreatic cancer constructed using orthotopic transplantation of histologically intact human tumor tissue in nude mice.

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12 December 2020

Androgen-independent cancer progression and bone metastasis in the LNCaP model of human prostate cancer

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12 December 2020

Governing step of metastasis visualized in vitro

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12 December 2020

A metastatic model of human colon cancer constructed using cecal implantation of cancer tissue in nude mice

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12 December 2020

Matrix metalloproteinase-1 is associated with poor prognosis in colorectal cancer

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12 December 2020

A "humanized" green fluorescent protein cDNA adapted for high-level expression in mammalian cells

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12 December 2020

Comparison of topoisomerase I inhibition, DNA damage, and cytotoxicity of camptothecin derivatives presently in clinical trials

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12 December 2020

Host organ specifically determines cancer progression

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12 December 2020

Human RT-4 bladder carcinoma is highly metastatic in nude mice and comparable to ras-H-transformed RT-4 when orthotopically onplanted as histologically intact tissue

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12 December 2020

Extensive liver metastasis from human colon cancer in nude and scid mice after orthotopic onplantation of histologically-intact human colon carcinoma tissue

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12 December 2020

Antimetastatic activity of the new platinum analog [Pt(cis-dach) (DPPE).2NO3] in a metastatic model of human bladder cancer

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12 December 2020

Prevention of hepatic metastasis of human colon cancer by angiogenesis inhibitor TNP-470

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12 December 2020

Reversible inhibition of IL-8 receptor B mRNA expression and proliferation in non-small cell lung cancer by antisense oligonucleotides

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12 December 2020

Orthotopic growth and metastasis of human prostate carcinoma in nude mice after transplantation of histologically intact tissue

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12 December 2020

Facilitation and suppression of bone metastasis.

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12 December 2020

Androgen-independent prostate cancer progression in the TRAMP model

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12 December 2020

Establishment of a metastatic model of human hepatocellular carcinoma in nude mice via orthotopic implantation of histologically intact tissues

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12 December 2020

Video microscopy of tumor metastasis: using the green fluorescent protein (GFP) gene as a cancer-cell-labeling system

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12 December 2020

Bisphosphonate risedronate reduces metastatic human breast cancer burden in bone in nude mice

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12 December 2020

A metastatic orthotopic-transplant nude-mouse model of human patient breast cancer

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12 December 2020

Consequences of widespread deregulation of the c-myc gene in transgenic mice: multiple neoplasms and normal development

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12 December 2020

Cancer invasion and micrometastasis visualized in live tissue by green fluorescent protein expression

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12 December 2020

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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12 December 2020

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12 December 2020

Metastatic patterns of lung cancer visualized live and in process by green fluorescence protein expression

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12 December 2020

Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes

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12 December 2020

Histoculture and the immunodeficient mouse come to the cancer clinic - rational approaches to individualizing cancer-therapy and new drug-evaluation (review).

1 reference

12 December 2020

Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo

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12 December 2020

Effective Electroporation Therapy of Human Pancreatic Tumors Implanted in Nude Mice.

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12 December 2020

Models of human metastatic colon cancer in nude mice orthotopically constructed by using histologically intact patient specimens

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12 December 2020

Bacterial lacZ gene as a highly sensitive marker to detect micrometastasis formation during tumor progression

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12 December 2020

Liver colonization competence governs colon cancer metastasis

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12 December 2020

Matrix metalloproteinase inhibitor BB-94 (batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice.

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12 December 2020

A "patient-like" nude mouse model of parietal pleural human lung adenocarcinoma

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12 December 2020

Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis

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12 December 2020

Use of green fluorescent protein variants to monitor gene transfer and expression in mammalian cells

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12 December 2020

Orthotopic and ectopic organ environments differentially influence the sensitivity of murine colon carcinoma cells to doxorubicin and 5-fluorouracil.

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12 December 2020

Cancer seed and soil can be highly selective: human-patient colon tumor lung metastasis grows in nude mouse lung but not colon or subcutis

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12 December 2020

Metastases from carcinoma of mammary gland: An autopsy study

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12 December 2020

Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease

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12 December 2020

Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease

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12 December 2020

Identifiers

DOI

10.1023/A:1006326203858

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PubMed ID

10759402

Dimensions Publication ID

29 July 2017

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1 reference

PubMed ID

10759402