(Q33889067)

29 July 2017

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title

Does mtDNA nucleoid organization impact aging? (English)

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29 July 2017

Daniel F Bogenhagen

1

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29 July 2017

publication date

11 December 2009

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29 July 2017

published in

Experimental Gerontology

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29 July 2017

volume

45

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29 July 2017

issue

7-8

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29 July 2017

page(s)

473-477

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When a theory of aging ages badly.

29 July 2017

cites work

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28 July 2018

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The mitochondrial theory of aging: insight from transgenic and knockout mouse models

28 July 2018

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The mitochondrial DNA genetic bottleneck results from replication of a subpopulation of genomes

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Mitochondrial nucleoids maintain genetic autonomy but allow for functional complementation

28 July 2018

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A mouse model of mitochondrial disease reveals germline selection against severe mtDNA mutations

28 July 2018

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Selection against pathogenic mtDNA mutations in a stem cell population leads to the loss of the 3243A-->G mutation in blood

28 July 2018

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Strong purifying selection in transmission of mammalian mitochondrial DNA

28 July 2018

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A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes

28 July 2018

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Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

28 July 2018

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The layered structure of human mitochondrial DNA nucleoids

28 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879461

Three-dimensional structure of the respiratory chain supercomplex I1III2IV1 from bovine heart mitochondria.

28 July 2018

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The mitochondrial transcription factor TFAM coordinates the assembly of multiple DNA molecules into nucleoid-like structures

28 July 2018

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Accumulation of mitochondrial DNA deletion mutations in aged muscle fibers: evidence for a causal role in muscle fiber loss

28 July 2018

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Mitochondrial fusion and fission in mammals

28 July 2018

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High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

28 July 2018

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A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine

28 July 2018

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Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

28 July 2018

1 reference

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Extension of murine life span by overexpression of catalase targeted to mitochondria

28 July 2018

1 reference

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Mitochondrial DNA mutations in human disease

28 July 2018

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Mitochondria in human oogenesis and preimplantation embryogenesis: engines of metabolism, ionic regulation and developmental competence

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879461

Premature ageing in mice expressing defective mitochondrial DNA polymerase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879461

The functional organization of mitochondrial genomes in human cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879461

Organization and dynamics of human mitochondrial DNA.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879461

Primordial germ cells in the mouse

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879461

Aging: a theory based on free radical and radiation chemistry

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879461

Mitochondrial respiratory-chain diseases

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879461

Identification of a gene causing human cytochrome c oxidase deficiency by integrative genomics

28 July 2018

1 reference

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Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879461

The role of maternal mitochondria during oogenesis, fertilization and embryogenesis

28 July 2018

1 reference

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Commuting the death sentence: how oocytes strive to survive

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879461

Mitochondrial DNA segregation in the developing embryo

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879461

The bottleneck: mitochondrial imperatives in oogenesis and ovarian follicular fate

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879461

Skewed segregation of the mtDNA nt 8993 (T-->G) mutation in human oocytes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879461

A proposed refinement of the mitochondrial free radical theory of aging

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879461

Distinct roles for two purified factors in transcription of Xenopus mitochondrial DNA.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879461

Molecular and cellular mechanisms of mitochondrial nuclear division and mitochondriokinesis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879461

The biologic clock: the mitochondria?

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879461

Unequal partitioning of bovine mitochondrial genotypes among siblings

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879461

Mitochondrial mutations may increase oxidative stress: implications for carcinogenesis and aging?

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879461

Primordial germ cells in the mouse embryo during gastrulation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879461

Myoclonic epilepsy and ragged-red fiber disease (MERRF) is associated with a mitochondrial DNA tRNA(Lys) mutation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879461

The evolution of ageing and longevity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879461

Is the oxidative stress theory of aging dead?

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879461

Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879461

The mitochondrial bottleneck occurs without reduction of mtDNA content in female mouse germ cells.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879461

Human mitochondrial DNA nucleoids are linked to protein folding machinery and metabolic enzymes at the mitochondrial inner membrane.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879461

Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879461

Origins of human mitochondrial point mutations as DNA polymerase gamma-mediated errors.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879461

Mitochondrial dysfunction in reproduction.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879461

DNA and RNA binding by the mitochondrial lon protease is regulated by nucleotide and protein substrate

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879461

A replicating module as the unit of mitochondrial structure and functioning

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879461

The remarkable structural and functional organization of the eukaryotic pyruvate dehydrogenase complexes

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879461

Random genetic drift in the female germline explains the rapid segregation of mammalian mitochondrial DNA.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879461

Purifying selection of mtDNA and its implications for understanding evolution and mitochondrial disease

29 October 2018

1 reference

12 December 2020

Mitochondrial DNA. I. Intramitochondrial distribution and structural relations of single- and double-length circular DNA

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12 December 2020

Number of mitochondria and some properties of mitochondrial DNA in the mouse egg

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12 December 2020

Generation of mice with mitochondrial dysfunction by introducing mouse mtDNA carrying a deletion into zygotes

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12 December 2020

The epidemiology of pathogenic mitochondrial DNA mutations

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12 December 2020

Mitochondria and germ-cell death

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12 December 2020

Action of mitochondrial DNA polymerase gamma at sites of base loss or oxidative damage

1 reference

12 December 2020

10.1016/J.EXGER.2009.12.002

Identifiers

DOI

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29 July 2017

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29 July 2017

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