(Q33891060)

English

Sequential metabolism of secondary alkyl amines to metabolic-intermediate complexes: opposing roles for the secondary hydroxylamine and primary amine metabolites of desipramine, (s)-fluoxetine, and N-desmethyldiltiazem

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Sequential metabolism of secondary alkyl amines to metabolic-intermediate complexes: opposing roles for the secondary hydroxylamine and primary amine metabolites of desipramine, (s)-fluoxetine, and N-desmethyldiltiazem (English)

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

author name string

Kelsey L Hanson

1

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Brooke M VandenBrink

2

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Kantipudi N Babu

3

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Kyle E Allen

4

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Wendel L Nelson

5

1 reference

Europe PubMed Central

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29 July 2017

Kent L Kunze

6

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

publication date

3 March 2010

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Drug Metabolism and Disposition

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Europe PubMed Central

PubMed publication ID

29 July 2017

38

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

963-972

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Time-dependent inhibition of human drug metabolizing cytochromes P450 by tricyclic antidepressants

1 reference

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5 July 2018

An in vitro model for predicting in vivo inhibition of cytochrome P450 3A4 by metabolic intermediate complex formation.

1 reference

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5 July 2018

Dose of midazolam should be reduced during diltiazem and verapamil treatments

1 reference

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5 July 2018

Cytochrome P-450 ligands: metyrapone revisited.

1 reference

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5 July 2018

Participation of cytochrome P-450 isozymes in N-demethylation, N-hydroxylation and aromatic hydroxylation of methamphetamine

1 reference

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5 July 2018

Cytochrome P-455 nm complex formation in the metabolism of phenylalkylamines. XII. Enantioselectivity and temperature dependence in microsomes and reconstituted cytochrome P-450 systems from rat liver

1 reference

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5 July 2018

The Stereoselective Metabolism of Ethylamphetamine with Fortified Rabbit Liver Homogenates

1 reference

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5 July 2018

The Formation of Cytochrome P-450-Metabolic Intermediate Complexes from Amines, in the Isolated Perfused Rat Liver

1 reference

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5 July 2018

Cytochrome P-455 complex formation in the metabolism of phenylalkylamines--IV. Spectral evidences for metabolic conversion of methamphetamine to N-hydroxyamphetamine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879960

5 July 2018

The formation of cytochrome P-450-metabolic intermediate complexes in microsomal fractions from extrahepatic tissues of the rabbit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879960

5 July 2018

Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. IX. The formation of a 455-nm metabolite-cytochrome P-450 complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879960

5 July 2018

Inhibition of CYP3A by erythromycin: in vitro-in vivo correlation in rats

1 reference

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29 October 2018

Semiphysiologically based pharmacokinetic models for the inhibition of midazolam clearance by diltiazem and its major metabolite.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879960

29 October 2018

Oxidation of tertiary amines by cytochrome p450-kinetic isotope effect as a spin-state reactivity probe

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879960

29 October 2018

Prediction of the effect of erythromycin, diltiazem, and their metabolites, alone and in combination, on CYP3A4 inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879960

29 October 2018

Sequential metabolism is responsible for diltiazem-induced time-dependent loss of CYP3A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879960

29 October 2018

Evaluation of time-dependent cytochrome P450 inhibition using cultured human hepatocytes.

1 reference

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29 October 2018

Prediction of time-dependent CYP3A4 drug-drug interactions: impact of enzyme degradation, parallel elimination pathways, and intestinal inhibition

1 reference

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29 October 2018

Cyclopropylamine inactivation of cytochromes P450: role of metabolic intermediate complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879960

29 October 2018

Evaluation of time-dependent inactivation of CYP3A in cryopreserved human hepatocytes

1 reference

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29 October 2018

Pharmacokinetic and pharmacodynamic evaluation of the inhibition of alprazolam by citalopram and fluoxetine

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29 October 2018

Enhanced rates of cytochrome P450 metabolic-intermediate complex formation from nonmacrolide amines in rifampicin-treated rabbit liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20200233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-throughput radiometric CYP2C19 inhibition assay using tritiated (S)-mephenytoin

1 reference

https://pubmed.ncbi.nlm.nih.gov/20200233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P-455-nm complex formation in the metabolism of phenylalkylamines. VI. Structure--activity relationships in metabolic intermediary complex formation with a series of alpha-substituted 2-phenylethylamines and corresponding N-hydroxylamines

1 reference

https://pubmed.ncbi.nlm.nih.gov/20200233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of alpha-carbon substituents on the N-demethylation of N-methyl-2-phenethylamines by rat liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20200233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of constitutive and phenobarbital-induced cytochrome P-450 isozymes during the sequential oxidation of benzphetamine. Explanation for the difference in benzphetamine-induced hydrogen peroxide production and 455-nm complex formation in mi

1 reference

https://pubmed.ncbi.nlm.nih.gov/20200233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism of imipramine in vitro: synthesis and characterization of N-hydroxydesmethylimipramine

1 reference

https://pubmed.ncbi.nlm.nih.gov/20200233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic deuterium isotope effects on deamination and N-hydroxylation of cyclohexylamine by rabbit liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20200233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of clarithromycin and its metabolites on the mixed function oxidase system in hepatic microsomes of rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/20200233

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based on heuristic

inferred from PubMed ID database lookup

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1 reference

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Identifiers

10.1124/DMD.110.032391

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

release_nfw363b6arcxrn2miyutb6rdci

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24 November 2022

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Europe PubMed Central

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29 July 2017

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Europe PubMed Central

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29 July 2017

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