(Q33892805)

29 July 2017

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title

Unmasking a killer: DNA O(6)-methylguanine and the cytotoxicity of methylating agents (English)

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29 July 2017

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Bignami M

1

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29 July 2017

O'Driscoll M

series ordinal

2

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29 July 2017

Aquilina G

series ordinal

3

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29 July 2017

Karran P

series ordinal

4

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29 July 2017

language of work or name

English

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publication date

1 April 2000

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29 July 2017

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29 July 2017

volume

462

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29 July 2017

issue

2-3

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29 July 2017

page(s)

71-82

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Nitrosamine-induced carcinogenesis. The alkylation of nucleic acids of the rat by N-methyl-N-nitrosourea, dimethylnitrosamine, dimethyl sulphate and methyl methanesulphonate

29 July 2017

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7 January 2021

Possible Relevance of O–6 Alkylation of Deoxyguanosine to the Mutagenicity and Carcinogenicity of Nitrosamines and Nitrosamides

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7 January 2021

Persistence of O 6-Ethylguanine in Rat-Brain DNA: Correlation with Nervous System-Specific Carcinogenesis by Ethylnitrosourea

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DNA synthesis with methylated poly(dC-dG) templates. Evidence for a competitive nature to miscoding by

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7 January 2021

DNA base changes induced following in vivo exposure of unadapted, adapted or ada- Escherichia coli to N-methyl-N'-nitro-N-nitrosoguanidine

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7 January 2021

Self-destruction and tolerance in resistance of mammalian cells to alkylation damage

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7 January 2021

A new pathway for DNA repair in Escherichia coli

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7 January 2021

Molecular cloning of a gene which regulates the adaptive response to alkylating agents in Escherichia coli

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7 January 2021

Regulation and expression of the adaptive response to alkylating agents

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7 January 2021

A system in mouse liver for the repair of O6-methylguanine lesions in methylated DNA.

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7 January 2021

Removal of O6-methylguanine from DNA by human liver fractions

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7 January 2021

Isolation and structural characterization of a cDNA clone encoding the human DNA repair protein for O6-alkylguanine

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7 January 2021

Expression and cloning of complementary DNA for a human enzyme that repairs O6-methylguanine in DNA.

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7 January 2021

Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains

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7 January 2021

Removal of O6-methylguanine from DNA of normal and xeroderma pigmentosum-derived lymphoblastoid lines.

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7 January 2021

Human brain tumour cell strains with deficient host-cell reactivation of N-methyl-N′-nitro-N-nitrosoguanidine-damaged adenovirus 5

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7 January 2021

Depletion of O6-methylguanine-DNA-methyltransferase in human fibroblasts increases the mutagenic response to N-methyl-N'-nitro-N-nitrosoguanidine

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7 January 2021

DNA damage tolerance, mismatch repair and genome instability

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Suppression of human DNA alkylation-repair defects by Escherichia coli DNA-repair genes

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7 January 2021

Expression in mammalian cells of a truncated Escherichia coli gene coding for O6-alkylguanine alkyltransferase reduces the toxic effects of alkylating agents.

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7 January 2021

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Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage

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7 January 2021

An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

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7 January 2021

Mismatch repair in Escherichia coli

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7 January 2021

Induced mutagenesis in dam − mutants of Escherichia coli: A role for 6-methyladenine residues in mutation avoidance

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7 January 2021

Mismatch correction at O 6 -methylguanine residues in E. coli DNA

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7 January 2021

1,N6-ethenoadenine is preferred over 3-methyladenine as substrate by a cloned human N-methylpurine-DNA glycosylase (3-methyladenine-DNA glycosylase)

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7 January 2021

Excision of hypoxanthine from DNA containing dIMP residues by the Escherichia coli, yeast, rat, and human alkylpurine DNA glycosylases

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7 January 2021

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7 January 2021

Adaptation to alkylation resistance involves the induction of a DNA glycosylase

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7 January 2021

Overexpression of N-methylpurine-DNA glycosylase in Chinese hamster ovary cells renders them more sensitive to the production of chromosomal aberrations by methylating agents--a case of imbalanced DNA repair

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7 January 2021

Alkylpurine-DNA-N-glycosylase knockout mice show increased susceptibility to induction of mutations by methyl methanesulfonate

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7 January 2021

Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes

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7 January 2021

Requirement of mammalian DNA polymerase-beta in base-excision repair.

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7 January 2021

Mismatch repair and differential sensitivity of mouse and human cells to methylating agents.

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7 January 2021

Resistance to 6-thioguanine in mismatch repair-deficient human cancer cell lines correlates with an increase in induced mutations at the HPRT locus.

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7 January 2021

Cytotoxic and mutagenic response of mismatch repair-defective human cancer cells exposed to a food-associated heterocyclic amine.

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7 January 2021

Cellular resistance and hypermutability in mismatch repair-deficient human cancer cell lines following treatment with methyl methanesulfonate.

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7 January 2021

Tissues of MSH2-deficient mice demonstrate hypermutability on exposure to a DNA methylating agent.

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7 January 2021

Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine

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7 January 2021

Carcinogenic N-nitrosamines in the diet: occurrence, formation, mechanisms and carcinogenic potential

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7 January 2021

N-nitrosation of medicinal drugs catalysed by bacteria from human saliva and gastro-intestinal tract, including Helicobacter pylori.

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7 January 2021

Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis

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7 January 2021

L-arginine-dependent formation of N-nitrosamines by the cytosol of macrophages activated with lipopolysaccharide and interferon-gamma

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7 January 2021

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Identifiers

DOI

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1 reference