(Q33892816)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10767622%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

review article

1 reference

title

Gene transfer to suppress bone marrow alkylation sensitivity (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10767622%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

author name string

R B Roth

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10767622%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

L D Samson

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10767622%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

language of work or name

English

0 references

publication date

1 April 2000

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10767622%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10767622%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

volume

462

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10767622%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

issue

2-3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10767622%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

page(s)

107-120

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10767622%20AND%20SRC:MED&resulttype=core&format=json

The Chemotherapy of Plasma-Cell Myeloma and the Incidence of Acute Leukemia

5 November 2019

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7 January 2021

Leukemia and Preleukemia after Adjuvant Treatment of Gastrointestinal Cancer with Semustine (Methyl-CCNU)

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7 January 2021

Risk of acute nonlymphocytic leukemia and preleukemia in patients treated with cyclophosphamide for non-Hodgkin's lymphomas. Comparison with results obtained in patients treated for Hodgkin's disease and ovarian carcinoma with other alkylating agent

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7 January 2021

DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells

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7 January 2021

The biology of alkylating-agent cellular injury.

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7 January 2021

DNA adducts from chemotherapeutic agents

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7 January 2021

A chemical and genetic approach together define the biological consequences of 3-methyladenine lesions in the mammalian genome

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7 January 2021

An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

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7 January 2021

Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage

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7 January 2021

O6-methylguanine in DNA inhibits DNA replication and stimulates DNA repair synthesis in vitro

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7 January 2021

Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials

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7 January 2021

Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents.

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7 January 2021

Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine

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7 January 2021

Thiotepa-induced myelosuppression: review of 670 bladder instillations.

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7 January 2021

Cyclophosphamide (Cytoxan). A review on relevant pharmacology and clinical uses

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7 January 2021

Nitrosoureas. Modes of action and perspectives in the use of hormone receptor affinity carrier molecules

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7 January 2021

Complications associated with the treatment of small cell lung cancer

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7 January 2021

Fotemustine in the treatment of brain primary tumors and metastases

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7 January 2021

Chromosome damage in the bone marrow of mice treated with the methylating agents methyl methanesulphonate and N-methyl-N-nitrosourea in the presence or absence of caffeine, and its relationship with thymoma induction

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7 January 2021

DNA repair methyltransferase (Mgmt) knockout mice are sensitive to the lethal effects of chemotherapeutic alkylating agents

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7 January 2021

A correlative study of the genetic damage induced by chemical mutagens in bone marrow and spermatogonia of mice. III. 1,3-Bis (2-chloroethyl)-3-nitrosourea (BCNU)

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7 January 2021

The level of DNA interstrand crosslinking in bone marrow parallels the extent of myelosuppression in mice treated with four chloroethylnitrosoureas

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7 January 2021

4-Hydroperoxycyclophosphamide inhibits proliferation by human granulocyte-macrophage colony-forming cells (GM-CFC) but spares more primitive progenitor cells.

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7 January 2021

Suppression of human DNA alkylation-repair defects by Escherichia coli DNA-repair genes

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7 January 2021

Reduction of the toxicity and mutagenicity of alkylating agents in mammalian cells harboring the Escherichia coli alkyltransferase gene

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7 January 2021

O6 alkylguanine-DNA alkyltransferase activity in human myeloid cells

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7 January 2021

Comparison of O6-alkylguanine-DNA alkyltransferase activity based on cellular DNA content in human, rat and mouse tissues.

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7 January 2021

Transfection of murine multi-potent haemopoietic stem cells with an E. coli DNA alkyltransferase gene confers resistance to the toxic effects of alkylating agents.

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7 January 2021

Increasing DNA repair methyltransferase levels via bone marrow stem cell transduction rescues mice from the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic alkylating agent

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7 January 2021

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7 January 2021

Viral vectors for gene therapy

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7 January 2021

Recombinant adeno-associated virus-mediated expression of O6-alkylguanine-DNA-alkyltransferase protects human epithelial and hematopoietic cells against chloroethylating agent toxicity

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7 January 2021

Efficient gene transfer into nondividing cells by adeno-associated virus-based vectors.

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7 January 2021

Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents

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7 January 2021

Mechanism of inactivation of human O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine

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7 January 2021

Retroviral transduction of a mutant methylguanine DNA methyltransferase gene into human CD34 cells confers resistance to O6-benzylguanine plus 1,3-bis(2-chloroethyl)-1-nitrosourea

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7 January 2021

Chemoprotective gene transfer I: transduction of human haemopoietic progenitors with O6-benzylguanine-resistant O6-alkylguanine-DNA alkyltransferase attenuates the toxic effects of O6-alkylating agents in vitro

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7 January 2021

Modulation of O6-alkylating agent induced clastogenicity by enhanced DNA repair capacity of bone marrow cells

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7 January 2021

Chemoprotective gene transfer II: multilineage in vivo protection of haemopoiesis against the effects of an antitumour agent by expression of a mutant human O6-alkylguanine-DNA alkyltransferase.

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7 January 2021

DeltaMGMT-transduced bone marrow infusion increases tolerance to O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea and allows intensive therapy of 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant human colon cancer xenografts.

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7 January 2021

Use of safety-modified retroviruses to introduce chemotherapy resistance sequences into normal hematopoietic cells for chemoprotection during the therapy of ovarian cancer: a pilot trial.

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7 January 2021

Human MDR gene transfer in patients with advanced cancer.

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7 January 2021

Retroviral mediated transfer of the human multidrug resistance gene (MDR-1) into hematopoietic stem cells during autologous transplantation after intensive chemotherapy for metastatic breast cancer

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7 January 2021

Results of MDR-1 vector modification trial indicate that granulocyte/macrophage colony-forming unit cells do not contribute to posttransplant hematopoietic recovery following intensive systemic therapy

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7 January 2021

Phase I trial of retroviral-mediated transfer of the human MDR1 gene as marrow chemoprotection in patients undergoing high-dose chemotherapy and autologous stem-cell transplantation.

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7 January 2021

Expression of a human complementary DNA for the multidrug resistance gene in murine hematopoietic precursor cells with the use of retroviral gene transfer.

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7 January 2021

Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1

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7 January 2021

Gene transfer into hematopoietic stem cells of nonhuman primates

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7 January 2021

Gene transfer into human haematopoietic stem cells

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7 January 2021

Transduction of hematopoietic stem cells in humans and in nonhuman primates

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7 January 2021

Retroviral-fibronectin interactions in transduction of mammalian cells

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7 January 2021

Establishing chemoresistance in hematopoietic progenitor cells

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7 January 2021

In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector

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7 January 2021

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7 January 2021

Lentiviral vectors--the promise of gene therapy within reach?

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7 January 2021

Inducible, high-level production of infectious murine leukemia retroviral vector particles pseudotyped with vesicular stomatitis virus G envelope protein

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7 January 2021

A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes

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7 January 2021

Generation of retroviral vector for clinical studies using transient transfection

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7 January 2021

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

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7 January 2021

Generation of packaging cell lines for pseudotyped retroviral vectors of the G protein of vesicular stomatitis virus by using a modified tetracycline inducible system

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7 January 2021

Rapid retroviral delivery of tetracycline-inducible genes in a single autoregulatory cassette

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7 January 2021

In vitro selection for K562 cells with higher retrovirally mediated copy number of aldehyde dehydrogenase class-1 and higher resistance to 4-hydroperoxycyclophosphamide

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7 January 2021

Retrovirus-mediated gene transfer of rat glutathione S-transferase Yc confers in vitro resistance to alkylating agents in human leukemia cells and in clonogenic mouse hematopoietic progenitor cells

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7 January 2021

Fibronectin fragment-facilitated retroviral transfer of the glutathione-S-transferase pi gene into CD34+ cells to protect them against alkylating agents.

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7 January 2021

A proof of glutathione S-transferase-pi-related multidrug resistance by transfer of antisense gene to cancer cells and sense gene to bone marrow stem cell

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7 January 2021

Modulation of cyclophosphamide activity by O6-alkylguanine-DNA alkyltransferase

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7 January 2021

10.1016/S1383-5742(00)00021-1

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10767622%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

1 reference