(Q33897793)

English

Apigenin induces DNA damage through the PKCδ-dependent activation of ATM and H2AX causing down-regulation of genes involved in cell cycle control and DNA repair.

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22985621%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Apigenin induces DNA damage through the PKCδ-dependent activation of ATM and H2AX causing down-regulation of genes involved in cell cycle control and DNA repair (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22985621%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

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13 February 2020

Michael A. Freitas

5

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13 February 2020

Erich Grotewold

6

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13 February 2020

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Arti Parihar

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13 February 2020

Frederick A Villamena

3

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13 February 2020

Liwen Wang

4

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13 February 2020

Andrea I Doseff

7

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13 February 2020

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14 September 2012

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13 February 2020

Biochemical Pharmacology

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13 February 2020

84

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13 February 2020

12

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13 February 2020

1571-1580

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Europe PubMed Central

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13 February 2020

describes a project that uses

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4097023/fullTextXML

based on heuristic

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The DNA damage response and cancer therapy

1 reference

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28 July 2018

Apigenin-induced apoptosis of leukemia cells is mediated by a bimodal and differentially regulated residue-specific phosphorylation of heat-shock protein-27.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097023

28 July 2018

Apigenin: a promising molecule for cancer prevention

1 reference

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Galectin-9 exhibits anti-myeloma activity through JNK and p38 MAP kinase pathways

1 reference

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28 July 2018

DNA damage and DNA damage responses in THP-1 monocytes after exposure to spores of either Stachybotrys chartarum or Aspergillus versicolor or to T-2 toxin

1 reference

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28 July 2018

Regulation of cell cycle and RNA transcription genes identified by microarray analysis of PC-3 human prostate cancer cells treated with luteolin

1 reference

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Targeting DNA topoisomerase II in cancer chemotherapy

1 reference

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28 July 2018

Cell cycle, CDKs and cancer: a changing paradigm

1 reference

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28 July 2018

The activity of extracellular signal-regulated kinase is required during G2/M phase before metaphase-anaphase transition in synchronized leukemia cell lines

1 reference

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28 July 2018

Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097023

28 July 2018

Serum starvation induces H2AX phosphorylation to regulate apoptosis via p38 MAPK pathway

1 reference

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28 July 2018

ATR: an essential regulator of genome integrity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097023

28 July 2018

Protein kinase Cdelta-dependent and -independent signaling in genotoxic response to treatment of desferroxamine, a hypoxia-mimetic agent

1 reference

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28 July 2018

Activation of p38 mitogen-activated protein kinase by celecoxib oppositely regulates survivin and gamma-H2AX in human colorectal cancer cells.

1 reference

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28 July 2018

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097023

28 July 2018

Bioflavonoids as poisons of human topoisomerase II alpha and II beta

1 reference

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28 July 2018

Apigenin-induced cell cycle arrest is mediated by modulation of MAPK, PI3K-Akt, and loss of cyclin D1 associated retinoblastoma dephosphorylation in human prostate cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097023

28 July 2018

p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097023

28 July 2018

Topoisomerase I inhibitors: camptothecins and beyond

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097023

28 July 2018

Apigenin-induced-apoptosis is mediated by the activation of PKCdelta and caspases in leukemia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097023

28 July 2018

Linear models and empirical bayes methods for assessing differential expression in microarray experiments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097023

28 July 2018

Protein kinase C delta activates topoisomerase IIalpha to induce apoptotic cell death in response to DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097023

28 July 2018

Peptide mass mapping of acetylated isoforms of histone H4 from mouse lymphosarcoma cells treated with histone deacetylase (HDACs) inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097023

28 July 2018

ATM signaling and genomic stability in response to DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097023

28 July 2018

Apigenin induces cell cycle arrest and p21/WAF1 expression in a p53-independent pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097023

28 July 2018

The Chemopreventive Bioflavonoid Apigenin Modulates Signal Transduction Pathways in Keratinocyte and Colon Carcinoma Cell Lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097023

28 July 2018

An experimental study of a Mediterranean diet intervention for patients with rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097023

28 July 2018

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097023

28 July 2018

The biochemistry and medical significance of the flavonoids

1 reference

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28 July 2018

Dietary flavonoids: bioavailability, metabolic effects, and safety

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097023

28 July 2018

A p21(waf1)-independent pathway for inhibitory phosphorylation of cyclin-dependent kinase p34(cdc2) and concomitant G(2)/M arrest by the chemopreventive flavonoid apigenin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097023

28 July 2018

The many substrates and functions of ATM

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097023

28 July 2018

Bioavailability of flavonoids and potential bioactive forms in vivo

1 reference

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28 July 2018

The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer

1 reference

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28 July 2018

The DNA damage response: putting checkpoints in perspective

1 reference

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28 July 2018

Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

1 reference

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28 July 2018

Inactivation of DNA-dependent protein kinase by protein kinase Cdelta: implications for apoptosis

1 reference

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28 July 2018

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

1 reference

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28 July 2018

The chemopreventive flavonoid apigenin induces G2/M arrest in keratinocytes

1 reference

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28 July 2018

Regulatory interactions among E2Fs and cell cycle control proteins

1 reference

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28 July 2018

Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097023

28 July 2018

A simple technique for quantitation of low levels of DNA damage in individual cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097023

28 July 2018

Strand scission in DNA by quercetin and Cu(II): identification of free radical intermediates and biological consequences of scission.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097023

28 July 2018

Phenolic composition and antioxidant activities of 11 celery cultivars

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097023

29 October 2018

Flavonoid intake and ovarian cancer risk in a population-based case-control study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097023

29 October 2018

Apigenin induced apoptosis through p53-dependent pathway in human cervical carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097023

29 October 2018

Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097023

29 October 2018

Investigation of double stranded DNA damage induced by quercetin-copper(II) using piezoelectric quartz crystal impedance technique and potentiometric stripping analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097023

29 October 2018

Regulation of cell apoptosis by protein kinase c delta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097023

29 October 2018

Apigenin inhibits growth and induces G2/M arrest by modulating cyclin-CDK regulators and ERK MAP kinase activation in breast carcinoma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097023

29 October 2018

Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097023

29 October 2018

Study of DNA damage induction and repair capacity of fresh and cryopreserved lymphocytes exposed to H2O2 and gamma-irradiation with the alkaline comet assay

1 reference

https://pubmed.ncbi.nlm.nih.gov/22985621

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22985621

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mediterranean diet improves erectile function in subjects with the metabolic syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/22985621

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selected novel flavones inhibit the DNA binding or the DNA religation step of eukaryotic topoisomerase I

1 reference

https://pubmed.ncbi.nlm.nih.gov/22985621

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C delta is essential for etoposide-induced apoptosis in salivary gland acinar cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22985621

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Strand scission in DNA induced by dietary flavonoids: role of Cu(I) and oxygen free radicals and biological consequences of scission

1 reference

https://pubmed.ncbi.nlm.nih.gov/22985621

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-4-induced apoptosis entails caspase activation and suppression of extracellular signal-regulated kinase phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22985621

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct mechanisms of DNA damage in apoptosis induced by quercetin and luteolin

1 reference

https://pubmed.ncbi.nlm.nih.gov/22985621

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of p21/WAF1 and G1 cell-cycle arrest by the chemopreventive agent apigenin

1 reference

https://pubmed.ncbi.nlm.nih.gov/22985621

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of parsley (Petroselinum crispum) intake on urinary apigenin excretion, blood antioxidant enzymes and biomarkers for oxidative stress in human subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/22985621

12 December 2020

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inferred from PubMed ID database lookup

A cross-platform public domain PC image-analysis program for the comet assay

1 reference

https://pubmed.ncbi.nlm.nih.gov/22985621

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor alpha: posttranscriptional stabilization of WAF1 mRNA in p53-deficient human leukemic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22985621

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.BCP.2012.09.005

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22985621%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22985621%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22985621%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

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