(Q33897930)

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Polycystin-2 activation by inositol 1,4,5-trisphosphate-induced Ca2+ release requires its direct association with the inositol 1,4,5-trisphosphate receptor in a signaling microdomain.

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30 January 2020

Polycystin-2 activation by inositol 1,4,5-trisphosphate-induced Ca2+ release requires its direct association with the inositol 1,4,5-trisphosphate receptor in a signaling microdomain (English)

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30 January 2020

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30 January 2020

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30 January 2020

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Eva Sammels

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30 January 2020

Benoit Devogelaere

2

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30 January 2020

Djalila Mekahli

3

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30 January 2020

Ludwig Missiaen

5

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30 January 2020

Yiqiang Cai

7

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30 January 2020

Stefan Somlo

8

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30 January 2020

Humbert De Smedt

9

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30 January 2020

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7 April 2010

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30 January 2020

Journal of Biological Chemistry

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30 January 2020

285

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30 January 2020

24

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30 January 2020

18794-18805

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30 January 2020

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11 June 2022

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Polycystin-1 interacts with inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling with implications for polycystic kidney disease

1 reference

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5 July 2018

A pathogenic C terminus-truncated polycystin-2 mutant enhances receptor-activated Ca2+ entry via association with TRPC3 and TRPC7

1 reference

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5 July 2018

Structural and molecular basis of the assembly of the TRPP2/PKD1 complex

1 reference

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5 July 2018

Ca2+-dependent conformational changes in a C-terminal cytosolic domain of polycystin-2.

1 reference

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5 July 2018

Autosomal dominant polycystic kidney disease: the last 3 years

1 reference

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5 July 2018

2008 Homer W. Smith Award: insights into the pathogenesis of polycystic kidney disease from gene discovery

1 reference

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5 July 2018

TRPP2 channels regulate apoptosis through the Ca2+ concentration in the endoplasmic reticulum

1 reference

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5 July 2018

Syntaxin 5 regulates the endoplasmic reticulum channel-release properties of polycystin-2.

1 reference

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5 July 2018

TRPP2 and TRPV4 form a polymodal sensory channel complex

1 reference

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5 July 2018

Domain mapping of the polycystin-2 C-terminal tail using de novo molecular modeling and biophysical analysis

1 reference

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5 July 2018

Formation of a new receptor-operated channel by heteromeric assembly of TRPP2 and TRPC1 subunits

1 reference

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5 July 2018

The complex regulatory function of the ligand-binding domain of the inositol 1,4,5-trisphosphate receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881802

5 July 2018

Inositol trisphosphate receptor Ca2+ release channels.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881802

5 July 2018

Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2

1 reference

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5 July 2018

Calcium: a fundamental regulator of intracellular membrane fusion?

1 reference

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5 July 2018

TRPP2 and autosomal dominant polycystic kidney disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881802

5 July 2018

Cell biology of polycystin-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881802

5 July 2018

Phosphorylation of IP3R1 and the regulation of [Ca2+]i responses at fertilization: a role for the MAP kinase pathway.

1 reference

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5 July 2018

The versatile nature of the calcium-permeable cation channel TRPP2

1 reference

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5 July 2018

Polycystin-2 traffics to cilia independently of polycystin-1 by using an N-terminal RVxP motif

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881802

5 July 2018

Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881802

5 July 2018

Polycystin 2 interacts with type I inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881802

5 July 2018

Subcellular localization and trafficking of polycystins

1 reference

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5 July 2018

Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation

1 reference

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5 July 2018

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

1 reference

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5 July 2018

Polycystin-2 is an intracellular calcium release channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881802

5 July 2018

Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents

1 reference

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5 July 2018

Molecular genetics and mechanism of autosomal dominant polycystic kidney disease

1 reference

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5 July 2018

Identification and characterization of polycystin-2, the PKD2 gene product

1 reference

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5 July 2018

Specific association of the gene product of PKD2 with the TRPC1 channel

1 reference

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Vesicle pools and Ca2+ microdomains: new tools for understanding their roles in neurotransmitter release

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5 July 2018

PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein

1 reference

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5 July 2018

Effects of Ca2+ chelators on purified inositol 1,4,5-trisphosphate (InsP3) receptors and InsP3-stimulated Ca2+ mobilization.

1 reference

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Rapid functional assays of recombinant IP3 receptors.

1 reference

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The N-terminal Ca2+-independent calmodulin-binding site on the inositol 1,4,5-trisphosphate receptor is responsible for calmodulin inhibition, even though this inhibition requires Ca2+.

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Calcium dependence of polycystin-2 channel activity is modulated by phosphorylation at Ser812.

1 reference

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Polycystin-1 distribution is modulated by polycystin-2 expression in mammalian cells

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Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys

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Transport function of the naturally occurring pathogenic polycystin-2 mutant, R742X.

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29 October 2018

Trypsinized cerebellar inositol 1,4,5-trisphosphate receptor. Structural and functional coupling of cleaved ligand binding and channel domains.

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Molecular and functional evidence for multiple Ca2+-binding domains in the type 1 inositol 1,4,5-trisphosphate receptor

1 reference

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inferred from PubMed ID database lookup

Somatic inactivation of Pkd2 results in polycystic kidney disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375013

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium restores a normal proliferation phenotype in human polycystic kidney disease epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375013

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autosomal dominant polycystic kidney disease: recent advances in pathogenesis and treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/20375013

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M109.090662

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Europe PubMed Central

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30 January 2020

1 reference

Europe PubMed Central

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30 January 2020

1 reference

Europe PubMed Central

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30 January 2020

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