(Q33900128)

29 July 2017

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title

Rb function in cell-cycle regulation and apoptosis (English)

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29 July 2017

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Harbour JW

1

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PubMed ID

10783254

29 July 2017

Dean DC

series ordinal

2

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29 July 2017

1 April 2000

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29 July 2017

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29 July 2017

2

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29 July 2017

E65-7

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29 July 2017

4

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https://scigraph.springernature.com/pub.10.1038/35008695

29 July 2017

0 references

cites work

Human retinoblastoma susceptibility gene: cloning, identification, and sequence.

1 reference

Structural evidence for the authenticity of the human retinoblastoma gene

21 January 2018

1 reference

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

21 January 2018

1 reference

The retinoblastoma protein and cell cycle control

21 January 2018

1 reference

Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells

21 January 2018

1 reference

The regulation of E2F by pRB-family proteins

21 January 2018

1 reference

Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells

21 January 2018

1 reference

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

21 January 2018

1 reference

The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product

21 January 2018

1 reference

21 January 2018

1 reference

Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes

21 January 2018

1 reference

Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1

21 January 2018

1 reference

E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product

21 January 2018

1 reference

Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein

21 January 2018

1 reference

Mechanism of active transcriptional repression by the retinoblastoma protein

21 January 2018

1 reference

A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites

21 January 2018

1 reference

Direct transcriptional repression by pRB and its reversal by specific cyclins

21 January 2018

1 reference

The retinoblastoma susceptibility gene product represses transcription when directly bound to the promoter

21 January 2018

1 reference

Expression of transcription factor E2F1 induces quiescent cells to enter S phase

21 January 2018

1 reference

Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein

21 January 2018

1 reference

The transcription factor E2F-1 is a downstream target of RB action

21 January 2018

1 reference

E2F is required to prevent inappropriate S-phase entry of mammalian cells

21 January 2018

1 reference

A rough guide to a smooth brain

21 January 2018

1 reference

Chromatin as an essential part of the transcriptional mechanim

21 January 2018

1 reference

ATP-dependent remodeling and acetylation as regulators of chromatin fluidity

21 January 2018

1 reference

Histone acetylation in chromatin structure and transcription

21 January 2018

1 reference

Nuclear histone acetylases and deacetylases and transcriptional regulation: HATs off to HDACs.

21 January 2018

1 reference

A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression

21 January 2018

1 reference

Histone deacetylase activity is required for full transcriptional repression by mSin3A

21 January 2018

1 reference

Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression

21 January 2018

1 reference

Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression

21 January 2018

1 reference

Retinoblastoma protein recruits histone deacetylase to repress transcription

21 January 2018

1 reference

Rb interacts with histone deacetylase to repress transcription

21 January 2018

1 reference

Retinoblastoma protein represses transcription by recruiting a histone deacetylase

21 January 2018

1 reference

RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins

21 January 2018

1 reference

The CBP co-activator stimulates E2F1/DP1 activity

21 January 2018

1 reference

A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor

21 January 2018

1 reference

The "dark side" of chromatin remodeling: repressive effects on transcription

21 January 2018

1 reference

Dissecting the regulatory circuitry of a eukaryotic genome

21 January 2018

1 reference

Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits

21 January 2018

1 reference

The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest

21 January 2018

1 reference

A role for retinoblastoma protein in potentiating transcriptional activation by the glucocorticoid receptor

21 January 2018

1 reference

RB and hbrm cooperate to repress the activation functions of E2F1

21 January 2018

1 reference

Differential regulation of retinoblastoma protein function by specific Cdk phosphorylation sites

21 January 2018

1 reference

Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation

21 January 2018

1 reference

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.

21 January 2018

1 reference

p14ARF links the tumour suppressors RB and p53.

21 January 2018

1 reference

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

1 reference

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

21 January 2018

1 reference

Effects of an Rb mutation in the mouse

21 January 2018

1 reference

Requirement for a functional Rb-1 gene in murine development

21 January 2018

1 reference

Temporally distinct patterns of p53-dependent and p53-independent apoptosis during mouse lens development.

21 January 2018

1 reference

E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction

21 January 2018

1 reference

Induction of DNA synthesis and apoptosis are separable functions of E2F-1.

21 January 2018

1 reference

E2F-1 potentiates cell death by blocking antiapoptotic signaling pathways

21 January 2018

1 reference

SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family

21 January 2018

1 reference

7 January 2021

Active transcriptional repression by the Rb-E2F complex mediates G1 arrest triggered by p16INK4a, TGFbeta, and contact inhibition

1 reference

7 January 2021

Regulation of E2F transcription by cyclin E-Cdk2 kinase mediated through p300/CBP co-activators

1 reference

7 January 2021

p53-dependent apoptosis suppresses tumor growth and progression in vivo

1 reference

7 January 2021

Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos

1 reference

7 January 2021

Identifiers

DOI

10.1038/35008695

1 reference

PubMed ID

10783254

Dimensions Publication ID

29 July 2017

0 references

1 reference

PubMed ID

10783254