(Q33901080)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10801470%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

title

Chemically induced dimerization of dihydrofolate reductase by a homobifunctional dimer of methotrexate (English)

1 reference

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6 November 2019

2

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6 November 2019

author name string

S J Kopytek

series ordinal

1

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6 November 2019

J C Dyer

series ordinal

3

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6 November 2019

J C Hu

series ordinal

4

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6 November 2019

publication date

1 May 2000

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6 November 2019

published in

Chemistry and Biology

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6 November 2019

volume

7

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6 November 2019

issue

5

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6 November 2019

page(s)

313-321

1 reference

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A versatile synthetic dimerizer for the regulation of protein-protein interactions

6 November 2019

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Proximity versus allostery: the role of regulated protein dimerization in biology

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Mechanistic studies of a signaling pathway activated by the organic dimerizer FK1012

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Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization.

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7 January 2021

Purification and properties of Escherichia coli dihydrofolate reductase

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7 January 2021

Effects of point mutations in a hinge region on the stability, folding, and enzymatic activity of Escherichia coli dihydrofolate reductase

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7 January 2021

The pharmacology and clinical use of methotrexate

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7 January 2021

Methotrexate analogues. 13. Chemical and pharmacological studies on amide, hydrazide, and hydroxamic acid derivatives of the glutamate side chain

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7 January 2021

Methotrexate analog. 32. Chain extension, .alpha.-carboxyl deletion, and .gamma. carboxyl replacement by sulfonate and phosphate. Effect on enzyme binding and cell-growth inhibition

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7 January 2021

Synthesis and in vitro biological activity of new deaza analogues of folic acid, aminopterin, and methotrexate with an L-ornithine side chain

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7 January 2021

Methotrexate analogues. 23. Synthesis, dihydrofolate reductase affinity, cytotoxicity, and in vivo antitumor activity of some putative degradation products of methotrexate-poly(L-lysine) conjugates.

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7 January 2021

Dihydrofolate Reductase: X-ray Structure of the Binary Complex with Methotrexate

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7 January 2021

Affinity modulation of small-molecule ligands by borrowing endogenous protein surfaces

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7 January 2021

Methotrexate analogs. 11. Unambiguous chemical synthesis and in vitro biological evaluation of .alpha.- and .gamma.-monoesters as potential prodrugs

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7 January 2021

Methotrexate analogues. 14. Synthesis of new gamma-substituted derivatives as dihydrofolate reductase inhibitors and potential anticancer agents

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7 January 2021

Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and Inhibitors

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7 January 2021

Selective coupling of methotrexate to peptide hormone carriers through a gamma-carboxamide linkage of its glutamic acid moiety: benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate activation in salt coupling

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7 January 2021

PyBOP®: A new peptide coupling reagent devoid of toxic by-product

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7 January 2021

19F NMR spectroscopy of [6-19F]tryptophan-labeled Escherichia coli dihydrofolate reductase: equilibrium folding and ligand binding studies

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7 January 2021

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7 January 2021

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Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10801470%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

1 reference