(Q33904251)

29 July 2017

Recent advances in the brain targeting of neuropharmaceuticals by chemical delivery systems (English)

1 reference

29 July 2017

Bodor N

1

1 reference

PubMed ID

10837718

29 July 2017

Buchwald P

series ordinal

2

1 reference

PubMed ID

10837718

29 July 2017

language of work or name

English

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publication date

1 April 1999

1 reference

Advanced Drug Delivery Reviews

29 July 2017

1 reference

29 July 2017

36

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29 July 2017

2-3

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29 July 2017

229-254

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Lipid Solubility and Drug Penetration of the Blood Brain Barrier

29 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Problems of delivery of drugs to the brain

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

The blood-brain barrier: principles for targeting peptides and drugs to the central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Blood-eye barriers in the rat: correlation of ultrastructure with function

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

One-month prevalence of mental disorders in the United States. Based on five Epidemiologic Catchment Area sites

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Fine structural localization of a blood-brain barrier to exogenous peroxidase

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Localization of drug-metabolizing enzyme activities to blood-brain interfaces and circumventricular organs.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Peptidases, peptides, and the mammalian blood-brain barrier

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

The active and passive exchanges of inorganic ions through the surfaces of living cells and through living membranes generally

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Facilitated transfer of glucose from blood into brain tissue

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Transport of glucose from blood to brain

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Anatomical barriers for antimicrobial agents

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

The functional role of P-glycoprotein in the blood-brain barrier

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Kinetics of the multidrug transporter (P-glycoprotein) and its reversal

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Linear Relationships between Lipophilic Character and Biological Activity of Drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Lipophilic Character and Biological Activity of Drugs II: The Parabolic Case

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Quantitative structure-pharmacokinetic relationships and drug design

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

The Correlation of Biological Activity of Plant Growth Regulators and Chloromycetin Derivatives with Hammett Constants and Partition Coefficients

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Where do general anaesthetics act?

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Development of a new physicochemical model for brain penetration and its application to the design of centrally acting H2 receptor histamine antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Hydrogen bonding. 33. Factors that influence the distribution of solutes between blood and brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Hydrogen bonding potential as a determinant of the in vitro and in situ blood-brain barrier permeability of peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Relationship between immobilised artificial membrane chromatographic retention and the brain penetration of structurally diverse drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Hydrogen bonding. 32. An analysis of water-octanol and water-alkane partitioning and the delta log P parameter of seiler.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Drug entry into the brain

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Molecular factors influencing drug transfer across the blood-brain barrier.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Parabolic dependence of drug action upon lipophilic character as revealed by a study of hypnotics

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Soft drugs: principles and methods for the design of safe drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Drug targeting via retrometabolic approaches

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Elimination of a Quaternary Pyridinium Salt Delivered as Its Dihydropyridine Derivative from Brain of Mice

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

A dihydropyridine carrier system for sustained delivery of 2',3'-dideoxynucleosides to the brain

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Site-specific, sustained release of drugs to the brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Improved delivery through biological membranes. 11. A redox chemical drug-delivery system and its use for brain-specific delivery of phenylethylamine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Improved delivery through biological membranes XIV: Brain-specific, sustained delivery of testosterone using a redox chemical delivery system

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Improved Delivery Through Biological Membranes. XXIV. Synthesis, in Vitro Studies, and in Vivo Characterization of Brain-Specific and Sustained Progestin Delivery Systems.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Evidence for prolonged suppression of stress-induced release of adrenocorticotropic hormone and corticosterone with a brain-enhanced dexamethasone-redox delivery system

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Effect of a chemical delivery system for dexamethasone (Dex-CDS) on peritumoral edema in an experimental brain tumor model.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Extension of a redox-based chemical delivery system to alpha, beta-unsaturated ketones

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Improved delivery through biological membranes. 32. Synthesis and biological activity of brain-targeted delivery systems for various estradiol derivatives.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

High-performance liquid chromatographic assay of a central nervous system (CNS)-directed estradiol chemical delivery system and its application after intravenous administration to rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

17 beta-estradiol attenuates fimbrial lesion-induced decline of ChAT-immunoreactive neurons in the rat medial septum

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Brain-specific chemical delivery systems for beta-lactam antibiotics. Synthesis and properties of some dihydropyridine and dihydroiosquinoline derivatives of benzylpenicillin

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Chemical delivery systems for some penicillinase-resistant semisynthetic penicillins.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Brain-specific chemical delivery systems for beta-lactam antibiotics. In vitro and in vivo studies of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Potential treatment of herpes simplex virus encephalitis by brain-specific delivery of trifluorothymidine using a dihydropyridine in equilibrium pyridinium salt type redox delivery system

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Carrier-mediated delivery of antiviral agents.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Synthesis of brain-targeted 1-(2-deoxy-2-fluoro-beta-D-ribofuranosyl)-(E)-5-(2-iodovinyl)uracil coupled to a dihydropyridine <---> pyridinium salt redox chemical-delivery system

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Brain, Blood, and Cerebrospinal Fluid Distribution of a Zidovudine Chemical Delivery System in Rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Evaluation of a brain-targeting zidovudine chemical delivery system in dogs

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

AIDS dementia: synthesis and properties of a derivative of 3'-azido-3'-deoxythymidine (AZT) that may become 'locked' in the central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

A pro-drug of zidovudine with enhanced efficacy against human immunodeficiency virus

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Synthesis and biological evaluation of prodrugs of zidovudine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Comparative pharmacokinetics of two prodrugs of zidovudine in rabbits: enhanced levels of zidovudine in brain tissue

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Brain targeting of anti-HIV nucleosides: synthesis and in vitro and in vivo studies of dihydropyridine derivatives of 3'-azido-2',3'-dideoxyuridine and 3'-azido-3'-deoxythymidine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Hybrid pharmacokinetic models to describe anti-HIV nucleoside brain disposition following parent and prodrug administration in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Enhanced delivery of ganciclovir to the brain through the use of redox targeting

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Improved delivery through biological membranes. XLV. Synthesis, physical-chemical evaluation, and brain uptake studies of 2-chloroethyl nitrosourea delivery systems.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Redox delivery system for brain-specific, sustained release of dopamine.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Improved delivery through biological membranes. 13. Brain-specific delivery of dopamine with a dihydropyridine in equilibrium with pyridinium salt type redox delivery system

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Synthesis and evaluation of a redox chemical delivery system for brain-enhanced dopamine containing an activated carbamate-type ester

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Anxiolytic activity of a brain delivery system for GABA.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Synthesis and evaluation of brain-targeted chemical delivery systems for the neurotrophomodulator 4-methylcatechol

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Improved anticonvulsant activity of phenytoin by a redox brain delivery system. III: Brain uptake and pharmacological effects

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

In vitro and in vivo investigations of dihydropyridine-based chemical delivery systems for anticonvulsants.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Synthesis, biological evaluation, calcium channel antagonist activity, and anticonvulsant activity of felodipine coupled to a dihydropyridine-pyridinium salt redox chemical delivery system.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Redox derivatives of tranylcypromine: syntheses, properties, and monoamine oxidase inhibitor activity of some chemical delivery systems

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Application of a brain-targeting chemical delivery system to 9-amino-1,2,3,4-tetrahydroacridine.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Improved delivery through biological membranes. XXXVII. Synthesis and stability of novel redox derivatives of naproxen and indomethacin

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Antihypertensive activity of redox derivatives of tryptophan.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

A strategy for delivering peptides into the central nervous system by sequential metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Brain-targeted delivery of a leucine-enkephalin analogue by retrometabolic design.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Strategies to target kyotorphin analogues to the brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Octanol-water partition of nonzwitterionic peptides: predictive power of a molecular size-based model

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Computer-assisted design of new drugs based on retrometabolic concepts.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Cardiovascular Complications of Oral Contraceptives

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Oral contraceptives, lipids and cardiovascular disease

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Role of female gonadal hormones in the CNS: clinical and experimental aspects

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

The Interaction of C-17 Esters of Estradiol with the Estrogen Receptor*

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Sustained brain-specific delivery of estradiol causes long-term suppression of luteinizing hormone secretion.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

A novel redox system for CNS-directed delivery of estradiol causes sustained LH suppression in castrate rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Medicinal applications of cyclodextrins

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Improved delivery through biological membranes. XXXL: Solubilization and stabilization of an estradiol chemical delivery system by modified beta-cyclodextrins

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Amorphous water-soluble derivatives of cyclodextrins: nontoxic dissolution enhancing excipients

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Solubilization and stabilization of a benzylpenicillin chemical delivery system by 2-hydroxypropyl-beta-cyclodextrin

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

Identification of two related pentapeptides from the brain with potent opiate agonist activity

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

A novel analgesic dipeptide from bovine brain is a possible Met-enkephalin releaser

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900090-8

7 January 2021

10.1016/S0169-409X(98)00090-8

Identifiers

DOI

1 reference

29 July 2017

1 reference

PubMed ID

10837718