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DJ-1 protects against oxidative damage by regulating the thioredoxin/ASK1 complex.
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scholarly article
1 reference
stated in
Europe PubMed Central
PMC publication ID
2883683
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20385180%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 January 2020
title
DJ-1 protects against oxidative damage by regulating the thioredoxin/ASK1 complex
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
2883683
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20385180%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 January 2020
author
M. Maral Mouradian
series ordinal
4
1 reference
stated in
Europe PubMed Central
PMC publication ID
2883683
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20385180%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 January 2020
author name string
Joo-Young Im
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1
1 reference
stated in
Europe PubMed Central
PMC publication ID
2883683
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20385180%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 January 2020
Kang-Woo Lee
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
2883683
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20385180%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 January 2020
Eunsung Junn
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
2883683
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20385180%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 January 2020
publication date
10 April 2010
1 reference
stated in
Europe PubMed Central
PMC publication ID
2883683
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20385180%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 January 2020
number of pages
6
1 reference
based on heuristic
inferred from page(s)
published in
Neuroscience Research
1 reference
stated in
Europe PubMed Central
PMC publication ID
2883683
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20385180%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 January 2020
volume
67
1 reference
stated in
Europe PubMed Central
PMC publication ID
2883683
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20385180%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 January 2020
issue
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
2883683
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20385180%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 January 2020
page(s)
203-208
1 reference
stated in
Europe PubMed Central
PMC publication ID
2883683
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20385180%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 January 2020
describes a project that uses
ImageJ
1 reference
stated in
Europe PubMed Central
retrieved
11 June 2022
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2883683/fullTextXML
based on heuristic
inferred from PubMed Central ID database lookup
cites work
Oxidizable residues mediating protein stability and cytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase 1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
28 July 2018
DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
28 July 2018
Regulation of apoptosis signal-regulating kinase 1 by protein phosphatase 2Cepsilon
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
28 July 2018
DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
28 July 2018
Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
28 July 2018
Critical role of ASK1 in the 6-hydroxydopamine-induced apoptosis in human neuroblastoma SH-SY5Y cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
28 July 2018
DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
28 July 2018
Recruitment of tumor necrosis factor receptor-associated factor family proteins to apoptosis signal-regulating kinase 1 signalosome is essential for oxidative stress-induced cell death
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
28 July 2018
Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
28 July 2018
Regulation of apoptosis signal-regulating kinase 1 (ASK1) by polyamine levels via protein phosphatase 5.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
28 July 2018
The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
28 July 2018
DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
28 July 2018
Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
28 July 2018
The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
28 July 2018
DJ-1 has a role in antioxidative stress to prevent cell death
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
28 July 2018
A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo-oligomerization.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
28 July 2018
The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
28 July 2018
Role of the ASK1-SEK1-JNK1-HIPK1 signal in Daxx trafficking and ASK1 oligomerization.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
28 July 2018
L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
28 July 2018
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
28 July 2018
DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
28 July 2018
Oxidized forms of peroxiredoxins and DJ-1 on two-dimensional gels increased in response to sublethal levels of paraquat
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
28 July 2018
Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
28 July 2018
Vitamin D3 up-regulated protein 1 mediates oxidative stress via suppressing the thioredoxin function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
28 July 2018
Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
28 July 2018
ASK1 is essential for JNK/SAPK activation by TRAF2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
28 July 2018
Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
28 July 2018
Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
28 July 2018
Redox activated MAP kinase death signaling cascade initiated by ASK1 is not activated in female mice following MPTP: novel mechanism of neuroprotection.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
29 October 2018
Mitochondrial localization of DJ-1 leads to enhanced neuroprotection
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
29 October 2018
Activation of apoptosis signal regulating kinase 1 (ASK1) and translocation of death-associated protein, Daxx, in substantia nigra pars compacta in a mouse model of Parkinson's disease: protection by alpha-lipoic acid
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
29 October 2018
PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson's disease rat model
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
29 October 2018
Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
29 October 2018
Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
29 October 2018
Activation of apoptosis signal-regulating kinase 1 by reactive oxygen species through dephosphorylation at serine 967 and 14-3-3 dissociation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
29 October 2018
Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
29 October 2018
The DJ-1L166P mutant protein associated with early onset Parkinson's disease is unstable and forms higher-order protein complexes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
29 October 2018
Crystal structures of human DJ-1 and Escherichia coli Hsp31, which share an evolutionarily conserved domain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
29 October 2018
Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883683
retrieved
29 October 2018
Identifiers
DOI
10.1016/J.NEURES.2010.04.002
1 reference
stated in
Europe PubMed Central
PMC publication ID
2883683
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20385180%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 January 2020
PMC publication ID
2883683
1 reference
stated in
Europe PubMed Central
PMC publication ID
2883683
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20385180%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 January 2020
PubMed publication ID
20385180
1 reference
stated in
Europe PubMed Central
PMC publication ID
2883683
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20385180%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 January 2020
ResearchGate publication ID
43130393
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