Home
Random
Nearby
Log in
Settings
Donate
About Wikidata
Disclaimers
Search
(Q33908049)
Watch
English
Mechanisms of action of cyclosporine.
scientific article published in May 2000
In more languages
default for all languages
No label defined
No description defined
edit
Statements
instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10878286
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10878286%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 November 2019
review article
1 reference
stated in
Europe PubMed Central
title
Mechanisms of action of cyclosporine
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10878286
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10878286%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 November 2019
author
Shigeo Koyasu
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10878286
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10878286%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 November 2019
author name string
S Matsuda
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10878286
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10878286%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 November 2019
publication date
1 May 2000
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10878286
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10878286%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 November 2019
published in
Immunopharmacology
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10878286
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10878286%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 November 2019
volume
47
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10878286
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10878286%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 November 2019
issue
2-3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10878286
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10878286%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 November 2019
page(s)
119-125
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10878286
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10878286%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 November 2019
cites work
SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Raf meets Ras: completing the framework of a signal transduction pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Probing Immunosuppressant Action with a Nonnatural Immunophilin Ligand
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Diversity in function and regulation of MAP kinase pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TGF-beta in kidney fibrosis: a target for gene therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Biological effects of cyclosporin A: A new antilymphocytic agent
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The structure and regulation of protein phosphatases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Views on Vav.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MAPKs: new JNK expands the group
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein kinase Ctheta, a selective upstream regulator of JNK/SAPK and IL-2 promoter activation in Jurkat T cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In situ hybridization for interleukin 2 and interleukin 2 receptor mRNA in T cells activated in the presence or absence of cyclosporin A.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cyclophilin: a specific cytosolic binding protein for cyclosporin A
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cyclosporine induces cancer progression by a cell-autonomous mechanism.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cooperation between Syk and Rac1 leads to synergistic JNK activation in T lymphocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cyclosporine
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The regulation of AP-1 activity by mitogen-activated protein kinases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
JNK or IKK, AP-1 or NF-kappaB, which are the targets for MEK kinase 1 action?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of angiotensin II in the tubulointerstitial fibrosis of obstructive nephropathy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Signal transduction through MAP kinase cascades
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential regulation of transforming growth factor beta and interleukin 2 genes in human T cells: demonstration by usage of novel competitor DNA constructs in the quantitative polymerase chain reaction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
FK-506 and cyclosporin A inhibit highly similar signal transduction pathways in human T lymphocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
T-cell receptor stimulation elicits an early phase of activation and a later phase of deactivation of the transcription factor NFAT1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The transforming growth factor-beta family
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
T lymphocyte activation signals for interleukin-2 production involve activation of MKK6-p38 and MKK7-SAPK/JNK signaling pathways sensitive to cyclosporin A
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The actions of cyclosporin A and FK506 suggest a novel step in the activation of T lymphocytes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
FK506 and Cyclosporin A Each Inhibit Antigen-Specific Signaling in the T Cell Line 171 in the Absence of a Calcium Signal
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A viral mechanism for inhibition of the cellular phosphatase calcineurin.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A calcineurin-dependent transcriptional pathway for cardiac hypertrophy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The MAP kinase cascade is essential for diverse signal transduction pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
NF-AT components define a family of transcription factors targeted in T-cell activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The oncogene product Vav is a crucial regulator of primary cytotoxic T cell responses but has no apparent role in CD28-mediated co-stimulation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TGF-beta and the endothelium during immune injury
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transcription factors of the NFAT family: regulation and function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Networking Rho family GTPases in lymphocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mitogen-activated protein kinase pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mitogen-activated protein kinases: specific messages from ubiquitous messengers
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein folding. Prolyl isomerases join the fold
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein serine/threonine phosphatases--new avenues for cell regulation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of transforming growth factor-beta 1 in experimental chronic cyclosporine nephropathy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Is cyclophilin involved in the immunosuppressive and nephrotoxic mechanism of action of cyclosporin A?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
JNK is involved in signal integration during costimulation of T lymphocytes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mitogen-activated protein kinase cascades and regulation of gene expression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Prevention of Cardiac Hypertrophy in Mice by Calcineurin Inhibition
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cyclosporine stimulates expression of transforming growth factor-beta in renal cells. Possible mechanism of cyclosporines antiproliferative effects.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A functional T-cell receptor signaling pathway is required for p95vav activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
T cell responses in calcineurin A alpha-deficient mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900192-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0162-3109(00)00192-2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10878286
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10878286%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 November 2019
PubMed publication ID
10878286
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10878286
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10878286%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 November 2019
Sitelinks
Wikipedia
(0 entries)
edit
Wikibooks
(0 entries)
edit
Wikinews
(0 entries)
edit
Wikiquote
(0 entries)
edit
Wikisource
(0 entries)
edit
Wikiversity
(0 entries)
edit
Wikivoyage
(0 entries)
edit
Wiktionary
(0 entries)
edit
Multilingual sites
(0 entries)
edit