(Q33909650)

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The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8254024%20AND%20SRC:MED&resulttype=core&format=json

28 October 2019

The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8254024%20AND%20SRC:MED&resulttype=core&format=json

28 October 2019

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Bruce N Cronstein

1

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8254024%20AND%20SRC:MED&resulttype=core&format=json

28 October 2019

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D Naime

2

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Europe PubMed Central

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28 October 2019

E Ostad

3

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8254024%20AND%20SRC:MED&resulttype=core&format=json

28 October 2019

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1 December 1993

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Europe PubMed Central

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28 October 2019

Journal of Clinical Investigation

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8254024%20AND%20SRC:MED&resulttype=core&format=json

28 October 2019

92

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8254024%20AND%20SRC:MED&resulttype=core&format=json

28 October 2019

6

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8254024%20AND%20SRC:MED&resulttype=core&format=json

28 October 2019

2675-2682

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8254024%20AND%20SRC:MED&resulttype=core&format=json

28 October 2019

Human mononuclear phagocytes express adenosine A1 receptors. A novel mechanism for differential regulation of Fc gamma receptor function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=288465

28 July 2018

Bone marrow transplantation only partially restores purine metabolites to normal in adenosine deaminase-deficient patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=288465

28 July 2018

Adenosine: a physiological modulator of superoxide anion generation by human neutrophils.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=288465

28 July 2018

Subclasses of external adenosine receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=288465

28 July 2018

Suppression of acute and chronic inflammation in adrenalectomized rats by pharmacologic amounts of prostaglandins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=288465

28 July 2018

Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=288465

28 July 2018

Heterologous desensitization of the inhibitory A1 adenosine receptor-adenylate cyclase system in rat adipocytes. Regulation of both Ns and Ni.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=288465

28 July 2018

Adenosine: an endogenous inhibitor of neutrophil-mediated injury to endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=288465

28 July 2018

Pertussis toxin reverses adenosine receptor-mediated inhibition of renin secretion in rat renal cortical slices

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=288465

28 July 2018

Rat fat-cells have three types of adenosine receptors (Ra, Ri and P). Differential effects of pertussis toxin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=288465

28 July 2018

Adenosine; a physiologic modulator of superoxide anion generation by human neutrophils. Adenosine acts via an A2 receptor on human neutrophils.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=288465

28 July 2018

Pertussis toxin reverses adenosine inhibition of neuronal glutamate release.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=288465

28 July 2018

Adenosine promotes neutrophil chemotaxis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=288465

28 July 2018

Dependence of an adenosine-activated potassium current on a GTP-binding protein in mammalian central neurons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=288465

28 July 2018

Increased adenosine concentration in blood from ischemic myocardium by AICA riboside. Effects on flow, granulocytes, and injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=288465

28 July 2018

A1 and A2 adenosine receptors in rabbit cortical collecting tubule cells. Modulation of hormone-stimulated cAMP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=288465

28 July 2018

Inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase, adenosine deaminase and 5'-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=288465

28 July 2018

Polyglutamation of methotrexate. Is methotrexate a prodrug?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=288465

28 July 2018

Selective adenosine release from human B but not T lymphoid cell line.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=288465

28 July 2018

Interstitial transudate purines in normoxic and hypoxic immature and mature rabbit hearts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=288465

28 July 2018

Fc gamma receptor-mediated functions in neutrophils are modulated by adenosine receptor occupancy. A1 receptors are stimulatory and A2 receptors are inhibitory

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=288465

28 July 2018

The antiinflammatory effects of adenosine receptor agonists on the carrageenan-induced pleural inflammatory response in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=288465

28 July 2018

The adenosine/neutrophil paradox resolved: human neutrophils possess both A1 and A2 receptors that promote chemotaxis and inhibit O2 generation, respectively

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=288465

28 July 2018

Methotrexate inhibits neutrophil function by stimulating adenosine release from connective tissue cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=288465

28 July 2018

The in vitro effects of methotrexate on peripheral blood mononuclear cells. Modulation by methyl donors and spermidine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=288465

28 July 2018

Alteration of purine metabolism by AICA-riboside in human B lymphoblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=288465

28 July 2018

A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=288465

28 July 2018

Extraction procedures for use prior to HPLC nucleotide analysis using microparticle chemically bonded packings

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=288465

28 July 2018

Adenosine regulates via two different types of receptors, the accumulation of cyclic AMP in cultured brain cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=288465

28 July 2018

Adenosine A2 receptors on human monocytes modulate C2 production

1 reference

https://pubmed.ncbi.nlm.nih.gov/8254024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of the poly-gamma-glutamyl metabolites of methotrexate in skin and other tissues of rats and hairless mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/8254024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for direct inhibition of de novo purine synthesis in human MCF-7 breast cells as a principal mode of metabolic inhibition by methotrexate

1 reference

https://pubmed.ncbi.nlm.nih.gov/8254024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methotrexate in rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/8254024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenosine inhibition of the hormonal response in the Sertoli cell is reversed by pertussis toxin

1 reference

https://pubmed.ncbi.nlm.nih.gov/8254024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel site of action of a high affinity A1 adenosine receptor antagonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/8254024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isobutylmethylxanthine stimulates adenylate cyclase by blocking the inhibitory regulatory protein, Gi

1 reference

https://pubmed.ncbi.nlm.nih.gov/8254024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reciprocal modulation of agonist and antagonist binding to A1 adenosine receptors by guanine nucleotides is mediated via a pertussis toxin-sensitive G protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/8254024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenosine receptors are expressed during differentiation of monocytes to macrophages in vitro. Implications for regulation of phagocytosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/8254024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of leukotriene B4 synthesis in neutrophils from patients with rheumatoid arthritis by a single oral dose of methotrexate

1 reference

https://pubmed.ncbi.nlm.nih.gov/8254024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leukocyte adherence in rat mesenteric venules: effects of adenosine and methotrexate

1 reference

https://pubmed.ncbi.nlm.nih.gov/8254024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenosine and a related carbocyclic nucleoside analogue selectively inhibit tumor necrosis factor-alpha production and protect mice against endotoxin challenge

1 reference

https://pubmed.ncbi.nlm.nih.gov/8254024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI116884

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8254024%20AND%20SRC:MED&resulttype=core&format=json

28 October 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8254024%20AND%20SRC:MED&resulttype=core&format=json

28 October 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8254024%20AND%20SRC:MED&resulttype=core&format=json

28 October 2019

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