(Q33910799)

30 July 2017

Flavopiridol inhibits P-TEFb and blocks HIV-1 replication (English)

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30 July 2017

Chao SH

1

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30 July 2017

Fujinaga K

2

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30 July 2017

Marion JE

3

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30 July 2017

Taube R

4

1 reference

30 July 2017

Sausville EA

5

1 reference

30 July 2017

Senderowicz AM

6

1 reference

30 July 2017

Peterlin BM

7

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30 July 2017

Price DH

8

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30 July 2017

language of work or name

English

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publication date

1 September 2000

1 reference

Journal of Biological Chemistry

30 July 2017

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30 July 2017

275

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30 July 2017

37

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30 July 2017

28345-28348

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Preclinical and clinical development of cyclin-dependent kinase modulators

30 July 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000446200

Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000446200

Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000446200

Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000446200

Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000446200

Identification of multiple cyclin subunits of human P-TEFb

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000446200

P-TEFb, a cyclin-dependent kinase controlling elongation by RNA polymerase II

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000446200

Transcription elongation factor P-TEFb is required for HIV-1 tat transactivation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000446200

Tat transactivation: a model for the regulation of eukaryotic transcriptional elongation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000446200

A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000446200

The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000446200

Highly divergent lentiviral Tat proteins activate viral gene expression by a common mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000446200

Control of formation of two distinct classes of RNA polymerase II elongation complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000446200

Control of RNA polymerase II elongation potential by a novel carboxyl-terminal domain kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000446200

Association of human immunodeficiency virus Nef protein with actin is myristoylation dependent and influences its subcellular localization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000446200

Purification of P-TEFb, a transcription factor required for the transition into productive elongation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000446200

Host-cell positive transcription elongation factor b kinase activity is essential and limiting for HIV type 1 replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000446200

P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000446200

Upregulation of cyclin T1/CDK9 complexes during T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000446200

Evidence that P-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000446200

NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000446200

HIV-1 Tat: coping with negative elongation factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000446200

Role of the human homolog of the yeast transcription factor SPT5 in HIV-1 Tat-activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000446200

Regulation of carboxyl-terminal domain phosphatase by HIV-1 tat protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000446200

A protein phosphatase functions to recycle RNA polymerase II

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000446200

Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000446200

21 January 2018

Identifiers

DOI

10.1074/JBC.C000446200

1 reference

30 July 2017

1 reference