(Q33916133)

30 July 2017

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title

2'-carbohydrate modifications in antisense oligonucleotide therapy: importance of conformation, configuration and conjugation (English)

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30 July 2017

M Manoharan

1

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30 July 2017

language of work or name

English

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publication date

1 December 1999

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30 July 2017

number of pages

14

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Biochimica et Biophysica Acta

inferred from page(s)

published in

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30 July 2017

volume

1489

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30 July 2017

issue

1

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30 July 2017

page(s)

117-130

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Kinetic characteristics of Escherichia coli RNase H1: cleavage of various antisense oligonucleotide-RNA duplexes

30 July 2017

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1 reference

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7 January 2021

The Influence of Antisense Oligonucleotide-induced RNA Structure on Escherichia coli RNase H1 Activity

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7 January 2021

Cleavage of single strand RNA adjacent to RNA-DNA duplex regions by Escherichia coli RNase H1.

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Binding affinity and specificity of Escherichia coli RNase H1: impact on the kinetics of catalysis of antisense oligonucleotide-RNA hybrids

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7 January 2021

Molecular cloning and expression of cDNA for human RNase H.

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Properties of cloned and expressed human RNase H1.

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Selective elimination of mRNAs in vivo: complementary oligodeoxynucleotides promote RNA degradation by an RNase H-like activity

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7 January 2021

How does RNase H recognize a DNA.RNA hybrid?

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7 January 2021

Sequence-dependent hydrolysis of RNA using modified oligonucleotide splints and RNase H

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7 January 2021

Backbone modifications in oligonucleotides and peptide nucleic acid systems

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7 January 2021

Conformational preorganization, hydration, and nucleic acid duplex stability

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7 January 2021

Characterization of fully 2'-modified oligoribonucleotide hetero- and homoduplex hybridization and nuclease sensitivity

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7 January 2021

Oligodeoxynucleotides containing 2'-O-modified adenosine: Synthesis and effects on stability of DNA:RNA duplexes

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Uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets

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Second-generation antisense oligonucleotides: structure-activity relationships and the design of improved signal-transduction inhibitors

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7 January 2021

2'-O-aminopropyl ribonucleotides: a zwitterionic modification that enhances the exonuclease resistance and biological activity of antisense oligonucleotides

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7 January 2021

The ups and downs of nucleic acid duplex stability: structure-stability studies on chemically-modified DNA:RNA duplexes

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7 January 2021

2'-O-(2-Methoxy)ethyl-modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level and inhibit formation of the ICAM-1 translation initiation complex in human umbilical vein endothelial cells.

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7 January 2021

Antisense oligonucleotide inhibition of hepatitis C virus gene expression in transformed hepatocytes

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Modification of splicing in the dystrophin gene in cultured Mdx muscle cells by antisense oligoribonucleotides

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7 January 2021

Restoration of correct splicing in thalassemic pre-mRNA by antisense oligonucleotides

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7 January 2021

Modulation of in vitro splicing of the upstream intron by modifying an intra-exon sequence which is deleted from the dystrophin gene in dystrophin Kobe

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7 January 2021

Repair of thalassemic human beta-globin mRNA in mammalian cells by antisense oligonucleotides

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7 January 2021

Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA

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7 January 2021

Antisense oligonucleotides: towards clinical trials

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7 January 2021

Toxicologic effects of an oligodeoxynucleotide phosphorothioate and its analogs following intravenous administration in rats

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7 January 2021

Correlating structure and stability of DNA duplexes with incorporated 2'-O-modified RNA analogues

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7 January 2021

RNA hydration: a detailed look

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7 January 2021

Hydration of the phosphate group in double-helical DNA

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7 January 2021

Structural characteristics of 2'-O-(2-methoxyethyl)-modified nucleic acids from molecular dynamics simulations

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7 January 2021

A 2'-O-thiol tether in the ribose moiety of nucleic acids for conjugation chemistry

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7 January 2021

Synthesis and electrochemistry of anthraquinone-oligodeoxynucleotide conjugates

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7 January 2021

Site-specific cross-linking of nucleic acids using the abasic site

1 reference

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7 January 2021

Structural properties of DNA:RNA duplexes containing 2'-O-methyl and 2'-S-methyl substitutions: a molecular dynamics investigation

1 reference

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7 January 2021

10.1016/S0167-4781(99)00138-4

Identifiers

DOI

1 reference

30 July 2017

1 reference