(Q33916133)

30 July 2017

1 reference

title

2'-carbohydrate modifications in antisense oligonucleotide therapy: importance of conformation, configuration and conjugation (English)

1 reference

30 July 2017

M Manoharan

1

1 reference

PubMed ID

10807002

30 July 2017

language of work or name

English

0 references

publication date

1 December 1999

1 reference

30 July 2017

14

1 reference

Biochimica et Biophysica Acta

inferred from page(s)

published in

1 reference

30 July 2017

1489

1 reference

30 July 2017

1

1 reference

30 July 2017

117-130

1 reference

Kinetic characteristics of Escherichia coli RNase H1: cleavage of various antisense oligonucleotide-RNA duplexes

30 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900138-4

7 January 2021

The influence of antisense oligonucleotide-induced RNA structure on Escherichia coli RNase H1 activity

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900138-4

7 January 2021

Cleavage of single strand RNA adjacent to RNA-DNA duplex regions by Escherichia coli RNase H1.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900138-4

7 January 2021

Binding affinity and specificity of Escherichia coli RNase H1: impact on the kinetics of catalysis of antisense oligonucleotide-RNA hybrids

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900138-4

7 January 2021

Molecular cloning and expression of cDNA for human RNase H.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900138-4

7 January 2021

Properties of cloned and expressed human RNase H1.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900138-4

7 January 2021

Selective elimination of mRNAs in vivo: complementary oligodeoxynucleotides promote RNA degradation by an RNase H-like activity

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900138-4

7 January 2021

How does RNase H recognize a DNA.RNA hybrid?

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900138-4

7 January 2021

Sequence-dependent hydrolysis of RNA using modified oligonucleotide splints and RNase H

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900138-4

7 January 2021

Backbone modifications in oligonucleotides and peptide nucleic acid systems

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900138-4

7 January 2021

Conformational preorganization, hydration, and nucleic acid duplex stability

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900138-4

7 January 2021

Characterization of fully 2'-modified oligoribonucleotide hetero- and homoduplex hybridization and nuclease sensitivity

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900138-4

7 January 2021

Oligodeoxynucleotides containing 2'-O-modified adenosine: synthesis and effects on stability of DNA:RNA duplexes

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900138-4

7 January 2021

Uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900138-4

7 January 2021

Second-generation antisense oligonucleotides: structure-activity relationships and the design of improved signal-transduction inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900138-4

7 January 2021

2'-O-aminopropyl ribonucleotides: a zwitterionic modification that enhances the exonuclease resistance and biological activity of antisense oligonucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900138-4

7 January 2021

The ups and downs of nucleic acid duplex stability: structure-stability studies on chemically-modified DNA:RNA duplexes

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900138-4

7 January 2021

2'-O-(2-Methoxy)ethyl-modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level and inhibit formation of the ICAM-1 translation initiation complex in human umbilical vein endothelial cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900138-4

7 January 2021

Antisense oligonucleotide inhibition of hepatitis C virus gene expression in transformed hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900138-4

7 January 2021

Modification of splicing in the dystrophin gene in cultured Mdx muscle cells by antisense oligoribonucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900138-4

7 January 2021

Restoration of correct splicing in thalassemic pre-mRNA by antisense oligonucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900138-4

7 January 2021

Modulation of in vitro splicing of the upstream intron by modifying an intra-exon sequence which is deleted from the dystrophin gene in dystrophin Kobe

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900138-4

7 January 2021

Repair of thalassemic human beta-globin mRNA in mammalian cells by antisense oligonucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900138-4

7 January 2021

Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900138-4

7 January 2021

Antisense oligonucleotides: towards clinical trials

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900138-4

7 January 2021

Toxicologic effects of an oligodeoxynucleotide phosphorothioate and its analogs following intravenous administration in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900138-4

7 January 2021

Correlating structure and stability of DNA duplexes with incorporated 2'-O-modified RNA analogues

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900138-4

7 January 2021

RNA hydration: a detailed look

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900138-4

7 January 2021

Hydration of the phosphate group in double-helical DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900138-4

7 January 2021

Structural characteristics of 2'-O-(2-methoxyethyl)-modified nucleic acids from molecular dynamics simulations

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900138-4

7 January 2021

A 2'-O-thiol tether in the ribose moiety of nucleic acids for conjugation chemistry

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900138-4

7 January 2021

Synthesis and electrochemistry of anthraquinone-oligodeoxynucleotide conjugates

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900138-4

7 January 2021

Site-specific cross-linking of nucleic acids using the abasic site

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900138-4

7 January 2021

Structural properties of DNA:RNA duplexes containing 2'-O-methyl and 2'-S-methyl substitutions: a molecular dynamics investigation

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900138-4

7 January 2021

10.1016/S0167-4781(99)00138-4

Identifiers

DOI

1 reference

30 July 2017

1 reference

PubMed ID

10807002