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Influenza virus sialidase: a target for drug discovery.
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Europe PubMed Central
PubMed publication ID
10818670
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10818670%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
review article
1 reference
stated in
Europe PubMed Central
title
Influenza virus sialidase: a target for drug discovery
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10818670
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10818670%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
main subject
drug discovery
1 reference
based on heuristic
inferred from title
author name string
M J Kiefel
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10818670
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10818670%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
M von Itzstein
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10818670
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10818670%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
publication date
1 January 1999
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10818670
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10818670%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
published in
Progress in medicinal chemistry
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10818670
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10818670%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
volume
36
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10818670
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10818670%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
page(s)
1-28
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10818670
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10818670%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
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A Virus Obtained from Influenza Patients
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7 January 2021
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7 January 2021
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Sialidases: structures, biological significance and therapeutic potential
1 reference
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Crossref
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7 January 2021
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Design and synthesis of carbohydrate-based inhibitors of protein-carbohydrate interactions
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7 January 2021
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Morphology of the isolated hemagglutinin and neuraminidase subunits of influenza virus
1 reference
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7 January 2021
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An estimation of the nucleotide substitution rate at defined positions in the influenza virus haemagglutinin gene
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7 January 2021
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Rapid evolution of RNA viruses
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7 January 2021
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inferred from DOI database lookup
Recent human influenza A (H1N1) viruses are closely related genetically to strains isolated in 1950
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Images in clinical medicine. Influenza A virus
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Influenza virus M2 protein has ion channel activity
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
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The structure and function of the hemagglutinin membrane glycoprotein of influenza virus
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
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7 January 2021
based on heuristic
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Influenza virus strains selectively recognize sialyloligosaccharides on human respiratory epithelium; the role of the host cell in selection of hemagglutinin receptor specificity
1 reference
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Crossref
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7 January 2021
based on heuristic
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Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
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7 January 2021
based on heuristic
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Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
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7 January 2021
based on heuristic
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Crystallographic detection of a second ligand binding site in influenza virus hemagglutinin
1 reference
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reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Crystal structures of influenza virus hemagglutinin in complex with high-affinity receptor analogs
1 reference
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reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Use of sialic acid analogues to define functional groups involved in binding to the influenza virus hemagglutinin.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Recognition of monovalent sialosides by influenza virus H3 hemagglutinin
1 reference
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7 January 2021
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Monovalent sialosides that bind tightly to influenza A virus
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Methyl alpha-glycoside of N-thioacetyl-D-neuraminic acid: a potential inhibitor of influenza A virus. A 1H NMR study
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Monomeric inhibitors of influenza neuraminidase enhance the hemagglutination inhibition activities of polyacrylamides presenting multiple C-sialoside groups
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Suppression of influenza virus infection by an N-thioacetylneuraminic acid acrylamide copolymer resistant to neuraminidase
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Effective inhibitors of hemagglutination by influenza virus synthesized from polymers having active ester groups. Insight into mechanism of inhibition
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Electron microscopy of influenza virus
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 A resolution
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of the catalytic and antigenic sites in influenza virus neuraminidase
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Three-dimensional structure of the neuraminidase of influenza virus A/Tokyo/3/67 at 2.2 A resolution
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Influenza virus neuraminidase: structure, antibodies, and inhibitors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Viral and bacterial neuraminidases
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Bacterial sialidases--roles in pathogenicity and nutrition
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Site-directed mutation of the active site of influenza neuraminidase and implications for the catalytic mechanism.
1 reference
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Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
Evidence for a sialosyl cation transition-state complex in the reaction of sialidase from influenza virus
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of substrate aglycon on enzyme mechanism in the reaction of sialidase from influenza virus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of temperature sensitive influenza virus mutants defective in neuraminidase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of cytochalasin B on the maturation of enveloped viruses
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
An electron microscopic study of the presence or absence of neuraminic acid in enveloped viruses
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanism of Arthrobacter sialophilus neuraminidase: the binding of substrates and transition-state analogs
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular modeling studies on ligand binding to sialidase from influenza virus and the mechanism of catalysis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The inhibition of neuraminidase and antiviral action
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of neuraminidase activity by derivatives of 2-deoxy-2,3-dehydro-N-acetylneuraminic acid
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of sialidases from viral, bacterial and mammalian sources by analogues of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid modified at the C-4 position
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Uptake, metabolism and excretion of orally and intravenously administered, double-labeled N-glycoloylneuraminic acid and single-labeled 2-deoxy-2,3-dehydro-N-acetylneuraminic acid in mouse and rat
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Synthesis of transition-state analogues as potential inhibitors of sialidase from Influenza virus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of bacterial and viral sialidases by 3-fluoro-N-acetylneuraminic acid
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
A sialic acid-derived phosphonate analog inhibits different strains of influenza virus neuraminidase with different efficiencies
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
New ganglioside analogs that inhibit influenza virus sialidase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Rational design of potent sialidase-based inhibitors of influenza virus replication
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A study of the active site of influenza virus sialidase: an approach to the rational design of novel anti-influenza drugs
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
A computational procedure for determining energetically favorable binding sites on biologically important macromolecules
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Geometries of functional group interactions in enzyme-ligand complexes: guides for receptor modelling
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
The synthesis of 2,3-didehydro-2,4-dideoxy-4-guanidinyl-N-acetylneuraminic acid: a potent influenza virus sialidase inhibitor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Three-dimensional structure of the complex of 4-guanidino-Neu5Ac2en and influenza virus neuraminidase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Safety and efficacy of the neuraminidase inhibitor GG167 in experimental human influenza
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid is a highly effective inhibitor both of the sialidase (neuraminidase) and of growth of a wide range of influenza A and B viruses in vitro
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of influenza virus replication in mice by GG167 (4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid) is consistent with extracellular activity of viral neuraminidase (sialidase)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
GG167 (4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid) is a potent inhibitor of influenza virus in ferrets
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chemoenzymatic synthesis of neuraminic acid analogs structurally varied at C-5 and C-9 as potential inhibitors of the sialidase from influenza virus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 1. Discovery, synthesis, biological activity, and structure-activity relationships of 4-guanidino- and 4-amino-4H-pyran-6-carboxamides
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of 4-amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure-based inhibitors of influenza virus sialidase. A benzoic acid lead with novel interaction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Design and synthesis of benzoic acid derivatives as influenza neuraminidase inhibitors using structure-based drug design
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Guanidinobenzoic acid inhibitors of influenza virus neuraminidase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
New Electronic Analogs of the Sialyl Cation: N-Functionalized 4-Acetamido-2,4-dihydroxypiperidines. Inhibition of Bacterial Sialidases
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Influenza virus sialidase: effect of calcium on steady-state kinetic parameters
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Fluorometric assay of neuraminidase with a sodium (4-methylumbelliferyl-alpha-D-N-acetylneuraminate) substrate
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenzavirus infections. GG167 Influenza Study Group.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Generation and characterization of an influenza virus neuraminidase variant with decreased sensitivity to the neuraminidase-specific inhibitor 4-guanidino-Neu5Ac2en
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular basis for the resistance of influenza viruses to 4-guanidino-Neu5Ac2en
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutation in the influenza virus neuraminidase gene resulting in decreased sensitivity to the neuraminidase inhibitor 4-guanidino-Neu5Ac2en leads to instability of the enzyme
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations affecting the sensitivity of the influenza virus neuraminidase to 4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Neuraminidase inhibitors as potential anti-influenza drugs.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure and diversity of influenza virus neuraminidase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The molecular biology of influenza virus pathogenicity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of receptor binding affinity of influenza virus hemagglutinin by its carbohydrate moiety
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Polymerized liposomes containing C-glycosides of sialic acid: potent inhibitors of influenza virus in vitro infectivity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Influenza type A virus neuraminidase does not play a role in viral entry, replication, assembly, or budding
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of mutants of influenza A virus selected with the neuraminidase inhibitor 4-guanidino-Neu5Ac2en
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations in a conserved residue in the influenza virus neuraminidase active site decreases sensitivity to Neu5Ac2en-derived inhibitors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970044-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0079-6468(08)70044-4
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10818670
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10818670%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
PubMed publication ID
10818670
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10818670
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10818670%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 November 2019
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