(Q33934466)

English

Effects of a novel orally administered calpain inhibitor SNJ-1945 on immunomodulation and neurodegeneration in a murine model of multiple sclerosis

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Effects of a novel orally administered calpain inhibitor SNJ-1945 on immunomodulation and neurodegeneration in a murine model of multiple sclerosis (English)

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

multiple sclerosis

0 references

1 reference

based on heuristic

inferred from title

neurodegeneration

1 reference

based on heuristic

inferred from title

author name string

Nicole Trager

1

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Amena Smith

2

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Gerald Wallace Iv

3

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Mitsuyoshi Azuma

4

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Jun Inoue

5

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Craig Beeson

6

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Azizul Haque

7

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Naren L Banik

8

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

language of work or name

0 references

publication date

12 February 2014

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Journal of Neurochemistry

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

130

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

268-279

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Multiple sclerosis: lessons from molecular neuropathology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107076

5 July 2018

Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107076

5 July 2018

Management and prognosis of multiple sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107076

5 July 2018

Calpain inhibition attenuates apoptosis of retinal ganglion cells in acute optic neuritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107076

5 July 2018

Decreased activity of the 20S proteasome in the brain white matter and gray matter of patients with multiple sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107076

5 July 2018

Regulation of Th1/Th17 cytokines and IDO gene expression by inhibition of calpain in PBMCs from MS patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107076

5 July 2018

Recent developments in approved and oral multiple sclerosis treatment and an update on future treatment options

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107076

5 July 2018

Calpeptin attenuated inflammation, cell death, and axonal damage in animal model of multiple sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107076

5 July 2018

Disturbed regulatory T cell homeostasis in multiple sclerosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107076

5 July 2018

Inhibition of calpain attenuates encephalitogenicity of MBP-specific T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107076

5 July 2018

Prevention of axonal injury using calpain inhibitor in chronic progressive experimental autoimmune encephalomyelitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107076

5 July 2018

The role of calcium-activated protease calpain in experimental retinal pathology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107076

5 July 2018

Increased calpain correlates with Th1 cytokine profile in PBMCs from MS patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107076

5 July 2018

Sustained elevation of intracellular cGMP causes oxidative stress triggering calpain-mediated apoptosis in photoreceptor degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107076

5 July 2018

Update on the relationships between neuropsychological dysfunction and structural MRI in multiple sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107076

5 July 2018

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107076

5 July 2018

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107076

5 July 2018

Statistical analysis of data from studies on experimental autoimmune encephalomyelitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107076

5 July 2018

Regulation of STAT signalling by proteolytic processing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107076

5 July 2018

The nature of multiple sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107076

5 July 2018

The CD4-Th1 model for multiple sclerosis: a critical [correction of crucial] re-appraisal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107076

5 July 2018

Human cerebrospinal fluid central memory CD4+ T cells: evidence for trafficking through choroid plexus and meninges via P-selectin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107076

5 July 2018

The novel calpain inhibitor SJA6017 improves functional outcome after delayed administration in a mouse model of diffuse brain injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107076

5 July 2018

Mechanism of myelin breakdown in experimental demyelination: a putative role for calpain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107076

5 July 2018

Axonal and neuronal degeneration in multiple sclerosis: mechanisms and functional consequences

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107076

5 July 2018

Calpain inhibitor I reduces the development of acute and chronic inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107076

5 July 2018

A putative mechanism of demyelination in multiple sclerosis by a proteolytic enzyme, calpain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107076

5 July 2018

Axonal pathology in multiple sclerosis: relationship to neurologic disability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107076

5 July 2018

Pathophysiological role of calpain in experimental demyelination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107076

5 July 2018

Increased calpain expression in activated glial and inflammatory cells in experimental allergic encephalomyelitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107076

5 July 2018

Calpain secreted by activated human lymphoid cells degrades myelin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107076

5 July 2018

Susceptibility of the Myelin-Associated Glycoprotein and Basic Protein to a Neutral Protease in Highly Purified Myelin from Human and Rat Brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107076

5 July 2018

Distribution of calcium activated neutral proteinase (mM CANP) in myelin and cytosolic fractions in bovine brain white matter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107076

5 July 2018

Increased calpain content and progressive degradation of neurofilament protein in spinal cord injury

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12659

21 January 2018

Calpain activation in apoptosis of ventral spinal cord 4.1 (VSC4.1) motoneurons exposed to glutamate: calpain inhibition provides functional neuroprotection

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12659

21 January 2018

Protein co-expression with axonal injury in multiple sclerosis plaques.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12659

21 January 2018

Repertoire dynamics of autoreactive T cells in multiple sclerosis patients and healthy subjects: epitope spreading versus clonal persistence.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12659

21 January 2018

Myelin basic protein, an autoantigen in multiple sclerosis, is selectively processed by human trypsin 4.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12659

21 January 2018

Amelioration of retinal degeneration and proteolysis in acute ocular hypertensive rats by calpain inhibitor ((1S)-1-((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12659

21 January 2018

Sex differences in experimental autoimmune encephalomyelitis in multiple murine strains

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12659

21 January 2018

Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12659

21 January 2018

The effects of calpain inhibition on IkB alpha degradation after activation of PBMCs: identification of the calpain cleavage sites

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12659

21 January 2018

Upregulation of calpain activity and expression in experimental allergic encephalomyelitis: a putative role for calpain in demyelination

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12659

21 January 2018

Natural naive CD4+CD25+CD127low regulatory T cell (Treg) development and function are disturbed in multiple sclerosis patients: recovery of memory Treg homeostasis during disease progression.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12659

21 January 2018

A novel calpain inhibitor for the treatment of acute experimental autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24447070

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Retinal penetration of calpain inhibitors in rats after oral administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/24447070

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-6-gp130-STAT3 in T cells directs the development of IL-17+ Th with a minimum effect on that of Treg in the steady state

1 reference

https://pubmed.ncbi.nlm.nih.gov/24447070

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Critical role of calpain in axonal damage-induced retinal ganglion cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/24447070

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Upregulation of calpain correlates with increased neurodegeneration in acute experimental auto-immune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24447070

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated neutral protease activity in myelin from brains of patients with multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24447070

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium-dependent neutral protease activity of myelin from bovine spinal cord: evidence for soluble cleavage products of myelin proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/24447070

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery

1 reference

https://pubmed.ncbi.nlm.nih.gov/24447070

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokine production in the central nervous system of Lewis rats with experimental autoimmune encephalomyelitis: dynamics of mRNA expression for interleukin-10, interleukin-12, cytolysin, tumor necrosis factor α and tumor necrosis factor β

1 reference

https://pubmed.ncbi.nlm.nih.gov/24447070

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Putative role of calpain in the pathophysiology of experimental optic neuritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24447070

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/JNC.12659

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

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