(Q33943541)

30 July 2017

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title

GABA potentiation: a logical pharmacological approach for the treatment of acute ischaemic stroke (English)

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30 July 2017

Green AR

1

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30 July 2017

Hainsworth AH

series ordinal

2

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30 July 2017

Jackson DM

series ordinal

3

1 reference

30 July 2017

publication date

1 July 2000

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30 July 2017

number of pages

12

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based on heuristic

inferred from page(s)

published in

Neuropharmacology

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30 July 2017

volume

39

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30 July 2017

issue

9

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30 July 2017

page(s)

1483-1494

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Elevated gamma-aminobutyric acid levels attenuate the metabolic response to bilateral ischemia.

30 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Attenuation by chlormethiazole administration of the rise in extracellular amino acids following focal ischaemia in the cerebral cortex of the rat.

7 January 2021

1 reference

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Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

7 January 2021

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7 January 2021

Epidemiology of stroke

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7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Regional rat brain benzodiazepine receptor number and gamma-aminobutyric acid concentration following a convulsion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Selective chromatolysis of neurons in the gerbil brain: a possible consequence of "epileptic" activity produced by common carotid artery occlusion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Role of hyperthermia in the protective action of clomethiazole against MDMA ('ecstasy')-induced neurodegeneration, comparison with the novel NMDA channel blocker AR-R15896AR.

7 January 2021

1 reference

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5-HT loss in rat brain following 3,4-methylenedioxymethamphetamine (MDMA), p-chloroamphetamine and fenfluramine administration and effects of chlormethiazole and dizocilpine

7 January 2021

1 reference

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From GABAA receptor diversity emerges a unified vision of GABAergic inhibition.

7 January 2021

1 reference

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Neuroprotective activity of chlormethiazole following transient forebrain ischaemia in the gerbil

7 January 2021

1 reference

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The protective action of chlormethiazole against ischaemia‐induced neurodegeneration in gerbils when infused at doses having little sedative or anticonvulsant activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Chlormethiazole antagonises seizures induced by N-methyl-DL-aspartate without interacting with the NMDA receptor complex.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

The modulation by chlormethiazole of the GABAA-receptor complex in rat brain

7 January 2021

1 reference

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Hippocampal GABA transporter function in temporal-lobe epilepsy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Clomethiazole (ZENDRA, CMZ) improves hind limb motor function and reduces neuronal damage after severe spinal cord injury in rat.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Stoichiometry of a ligand-gated ion channel determined by fluorescence energy transfer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

MK-801 is neuroprotective in gerbils when administered during the post-ischaemic period

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Glutamate as a candidate retrograde messenger at interneurone-Purkinje cell synapses of rat cerebellum.

7 January 2021

1 reference

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Clomethiazole (Zendra) in acute ischemic stroke: basic pharmacology and biochemistry and clinical efficacy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Attenuation by chlormethiazole of oedema following focal ischaemia in the cerebral cortex of the rat.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

A simple intravenous infusion method in rodents for determining the potency of anticonvulsants acting through GABAergic mechanisms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

The immediate consequences of middle cerebral artery occlusion on GABA synthesis in mouse cortex and cerebellum

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

The neurotoxic effects of methamphetamine on 5-hydroxytryptamine and dopamine in brain: evidence for the protective effect of chlormethiazole

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Inhibition of the rate of GABA synthesis in regions of rat brain following a convulsion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Inhibition of GABA release from slices prepared from several brain regions of rats at various times following a convulsion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

An investigation of the possible interaction of clomethiazole with glutamate and ion channel sites as an explanation of its neuroprotective activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

A behavioural and neurochemical study in rats of the pharmacology of loreclezole, a novel allosteric modulator of the GABAA receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Ischemia-induced shift of inhibitory and excitatory amino acids from intra- to extracellular compartments.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Modulation of GABAA and glycine receptors by chlormethiazole

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Two distinct interactions of barbiturates and chlormethiazole with the GABAA receptor complex in rat cuneate nucleus in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Animal models of acute ischaemic stroke: can they predict clinically successful neuroprotective drugs?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Postischemic inhibition of GABA reuptake by tiagabine slows neuronal death in the gerbil hippocampus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Neuroprotective properties of propofol and midazolam, but not pentobarbital, on neuronal damage induced by forebrain ischemia, based on the GABAA receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

High dose baclofen is neuroprotective but also causes intracerebral hemorrhage: a quantal bioassay study using the intraluminal suture occlusion method

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Enhancement of GABA neurotransmission after cerebral ischemia in the rat reduces loss of hippocampal CA1 pyramidal cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Inhibition in postischemic rat hippocampus: GABA receptors, GABA release, and inhibitory postsynaptic potentials

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

A dendritic GABAA-mediated IPSP regulates facilitation of NMDA-mediated responses to burst stimulation of afferent fibers in piriform cortex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Intracerebral human microdialysis. In vivo study of an acute focal ischemic model of the human brain.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Does neuroprotection improve stroke outcome?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Effects of clomethiazole on radial-arm maze performance following global forebrain ischemia in gerbils.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Protective effect of synaptic inhibition during cerebral ischemia in rats and rabbits

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Combination therapy protects ischemic brain in rats. A glutamate antagonist plus a gamma-aminobutyric acid agonist

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Combination Chemotherapy Extends the Therapeutic Window to 60 Minutes After Stroke

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Effect of ganaxolone in a rodent model of cerebral hematoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Presynaptic ionotropic receptors and the control of transmitter release.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

The attenuation of kainate-induced neurotoxicity by chlormethiazole and its enhancement by dizocilpine, muscimol, and adenosine receptor agonists.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

New models of focal cerebral ischaemia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Effect of gamma-aminobutyric acid modulation on neuronal ischemia in rabbits

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

GABA concentrations in the striatum following repetitive cerebral ischemia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Pharmacological modulation of GABA(A) receptor-mediated postsynaptic potentials in the CA1 region of the rat hippocampus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Functional benefit from clomethiazole treatment after focal cerebral ischemia in a nonhuman primate species.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Modulation of inhibitory synapses in the mammalian brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

An update on GABAA receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Chlormethiazole: neurochemical actions at the gamma-aminobutyric acid receptor complex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Evidence for metabotropic glutamate receptor activation in the induction of depolarization-induced suppression of inhibition in hippocampal CA1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Neuroprotection for acute stroke: making clinical trials work

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Preservation of GABAergic perikarya and boutons after transient ischemia in the gerbil hippocampal CA1 field.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

CI-966, a GABA uptake inhibitor, antagonizes ischemia-induced neuronal degeneration in the gerbil

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Transmitter amino acid release from rat neocortex: complete versus incomplete ischemia models

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Amino acid and purine release in rat brain following temporary middle cerebral artery occlusion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

High extracellular GABA levels in hippocampus--as a mechanism of neuronal protection in cerebral ischemia in adrenalectomized gerbils

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Resolving GABAA/benzodiazepine receptors: cellular and subcellular localization in the CNS with monoclonal antibodies.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

N-methylaspartate-activated calcium channels in rat brain cortex slices. Effect of calcium channel blockers and of inhibitory and depressant substances

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Baclofen does not protect against cerebral ischemia in rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Presynaptic inhibition of muscle spindle and tendon organ afferents in the mammalian spinal cord

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Delayed transneuronal death of substantia nigra neurons prevented by gamma-aminobutyric acid agonist

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Long-term neuroprotection by benzodiazepine full versus partial agonists after transient cerebral ischemia in the gerbil [corrected]

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Postischemic diazepam is neuroprotective in the gerbil hippocampus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Diazepam, given postischemia, protects selectively vulnerable neurons in the rat hippocampus and striatum.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Neuropharmacological investigations on muscimol, a psychotropic drug extracted from Amanita muscaria

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Gamma-vinyl GABA prevents hippocampal and substantia nigra reticulata damage in repetitive transient forebrain ischemia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Clomethiazole protects the brain in transient forebrain ischemia when used up to 4 h after the insult

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Progressive decrease in extracellular GABA concentrations in the post-ischemic period in the striatum: a microdialysis study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

GABA agonist "muscimol" is neuroprotective in repetitive transient forebrain ischemia in gerbils

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

The neuroprotective effects of gamma-vinyl GABA in transient global ischemia: a morphological study with early and delayed evaluations.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

The effects of chlormethiazole and nimodipine on cortical infarct area after focal cerebral ischaemia in the rat.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Subcellular localization of benzodiazepine/GABAA receptors in the cerebellum of rat, cat, and monkey using monoclonal antibodies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Effects of felbamate on veratridine- and K(+)-stimulated release of glutamate from mouse cortex.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Role for gamma-aminobutyric acid in selective vulnerability in gerbils

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

The neuroprotective effect of chlormethiazole on ischaemic neuronal damage following permanent middle cerebral artery ischaemia in the rat

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

The effect of chlormethiazole on neuronal damage in a model of transient focal ischaemia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

The effect of oedema and tissue swelling on the measurement of neuroprotection; a study using chlormethiazole and permanent middle cerebral artery occlusion in rats.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

GABAergic neocortical neurons are resistant to NMDA receptor-mediated injury.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Is chlormethiazole neuroprotective in experimental global cerebral ischemia? A microdialysis and behavioral study.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Chlormethiazole attenuates the derangement of sensory evoked potential (SEP) induced by ICV administration of NMDA

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Insulin attenuates ischemic brain damage independent of its hypoglycemic effect.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Postischemic seizures and necrotizing ischemic brain damage: neuroprotective effect of postischemic diazepam and insulin.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Clomethiazole acute stroke study (CLASS): results of a randomized, controlled trial of clomethiazole versus placebo in 1360 acute stroke patients

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Interaction of allosteric ligands with GABAA receptors containing one, two, or three different subunits

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

GABA-activated chloride channels in secretory nerve endings

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Interactions between loreclezole, chlormethiazole and pentobarbitone at GABA(A) receptors: functional and binding studies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Spinal cord infarction: a highly reproducible stroke model

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

Techniques for examining neuroprotective drugs in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0028-3908%2899%2900233-6

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0028-3908(99)00233-6

1 reference

30 July 2017

1 reference