(Q33944309)

25003188

30 July 2017

title

Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1 (English)

1 reference

30 July 2017

1

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11 June 2020

Pamela Ohashi

11

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11 June 2020

Casey T. Weaver

12

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11 June 2020

author name string

Heather D Marshall

2

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11 June 2020

Matthew M Staron

3

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11 June 2020

Philipp A Lang

4

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11 June 2020

Anne Brüstle

5

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11 June 2020

Jonathan H Chen

6

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11 June 2020

Weiguo Cui

7

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11 June 2020

Yao-Chen Tsui

8

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11 June 2020

Curtis Perry

9

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11 June 2020

Brian J Laidlaw

10

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11 June 2020

Susan M Kaech

13

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11 June 2020

language of work or name

English

0 references

publication date

8 July 2014

1 reference

25003188

Journal of Clinical Investigation

30 July 2017

published in

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11 June 2020

volume

124

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11 June 2020

issue

8

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11 June 2020

page(s)

3455-3468

1 reference

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Molecular and transcriptional basis of CD4⁺ T cell dysfunction during chronic infection

11 June 2020

cites work

1 reference

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Macrophage and T cell produced IL-10 promotes viral chronicity

5 July 2018

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Monocyte-derived dendritic cells perform hemophagocytosis to fine-tune excessive immune responses

5 July 2018

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Insights into the role of Bcl6 in follicular Th cells using a new conditional mutant mouse model

5 July 2018

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Distinct memory CD4+ T cells with commitment to T follicular helper- and T helper 1-cell lineages are generated after acute viral infection.

5 July 2018

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Infected CD8α- dendritic cells are the predominant source of IL-10 during establishment of persistent viral infection

5 July 2018

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Emergence of distinct multiarmed immunoregulatory antigen-presenting cells during persistent viral infection

5 July 2018

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IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection

5 July 2018

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Differential expression of Ly6C and T-bet distinguish effector and memory Th1 CD4(+) cell properties during viral infection

5 July 2018

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Loss of memory B cells during chronic HIV infection is driven by Foxo3a- and TRAIL-mediated apoptosis.

5 July 2018

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ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6

5 July 2018

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The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns

5 July 2018

1 reference

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The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109559

The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells

5 July 2018

1 reference

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Follicular helper CD4 T cells (TFH)

5 July 2018

1 reference

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CD4+ T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109559

Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109559

The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109559

Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109559

IRF4 and its regulators: evolving insights into the pathogenesis of inflammatory arthritis?

5 July 2018

1 reference

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IL-10 directly suppresses CD4 but not CD8 T cell effector and memory responses following acute viral infection

5 July 2018

1 reference

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Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109559

A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection.

5 July 2018

1 reference

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Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties

5 July 2018

1 reference

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Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109559

Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation

5 July 2018

1 reference

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Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo

5 July 2018

1 reference

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Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells

5 July 2018

1 reference

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A vital role for interleukin-21 in the control of a chronic viral infection

5 July 2018

1 reference

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IL-21 is required to control chronic viral infection

5 July 2018

1 reference

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Identification and characterization of IL-10/IFN-gamma-producing effector-like T cells with regulatory function in human blood

5 July 2018

1 reference

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IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells

5 July 2018

1 reference

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Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10.

5 July 2018

1 reference

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Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109559

ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109559

Presence of suppressor HIV-specific CD8+ T cells is associated with increased PD-1 expression on effector CD8+ T cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109559

CD8 T cell dysfunction during chronic viral infection.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109559

Interleukin-10 plays an early role in generating virus-specific T cell anergy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109559

Splenic accumulation of IL-10 mRNA in T cells distinct from CD4+CD25+ (Foxp3) regulatory T cells in human visceral leishmaniasis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109559

Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109559

Interleukin-10 determines viral clearance or persistence in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109559

Resolution of a chronic viral infection after interleukin-10 receptor blockade

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109559

Restoring function in exhausted CD8 T cells during chronic viral infection

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109559

Impaired humoral immunity in X-linked lymphoproliferative disease is associated with defective IL-10 production by CD4+ T cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109559

Antigen-driven effector CD8 T cell function regulated by T-bet

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109559

Role for IL-10 in inducing functional impairment of monocytes upon TLR4 ligation in patients with chronic HCV infections

5 July 2018

1 reference

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Cutting edge: Plasmacytoid dendritic cells induce IL-10 production in T cells via the Delta-like-4/Notch axis.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109559

IL-21R on T cells is critical for sustained functionality and control of chronic viral infection

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109559

Differential role of IL-2R signaling for CD8+ T cell responses in acute and chronic viral infections.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109559

Cytokine-dependent Blimp-1 expression in activated T cells inhibits IL-2 production.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109559

Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109559

Virus-specific MHC-class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109559

Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo

29 October 2018

1 reference

12 December 2020

Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals

1 reference

12 December 2020

Increased natural cytotoxicity receptor expression and relevant IL-10 production in NK cells from chronically infected viremic HCV patients

1 reference

12 December 2020

Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10

1 reference

12 December 2020

Blimp-1 attenuates Th1 differentiation by repression of ifng, tbx21, and bcl6 gene expression

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI66108

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25003188%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25003188%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

25003188

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25003188%20AND%20SRC:MED&resulttype=core&format=json