(Q33953392)

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Post-transcriptional down-regulation of ROCKI/Rho-kinase through an MEK-dependent pathway leads to cytoskeleton disruption in Ras-transformed fibroblasts

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scholarly article

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Europe PubMed Central

PubMed publication ID

30 July 2017

Post-transcriptional down-regulation of ROCKI/Rho-kinase through an MEK-dependent pathway leads to cytoskeleton disruption in Ras-transformed fibroblasts (English)

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

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author name string

Geraldine Pawlak

1

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

David M Helfman

2

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Europe PubMed Central

PubMed publication ID

30 July 2017

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1 January 2002

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Europe PubMed Central

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30 July 2017

Molecular Biology of the Cell

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Europe PubMed Central

PubMed publication ID

30 July 2017

13

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Europe PubMed Central

PubMed publication ID

30 July 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

336-347

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility

1 reference

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Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells

1 reference

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Cytoskeletal changes in cell transformation and tumorigenesis

1 reference

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Reversal of the Ras-induced transformed phenotype by HR12, a novel ras farnesylation inhibitor, is mediated by the Mek/Erk pathway

1 reference

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Cleavage of focal adhesion kinase by different proteases during SRC-regulated transformation and apoptosis. Distinct roles for calpain and caspases.

1 reference

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Ras and Rho GTPases: a family reunion

1 reference

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Active ERK/MAP kinase is targeted to newly forming cell-matrix adhesions by integrin engagement and v-Src

1 reference

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Rho GTPases and their effector proteins

1 reference

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Suppression of tumorigenicity in breast cancer cells by the microfilament protein profilin 1.

1 reference

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U0126 reverses Ki-ras-mediated transformation by blocking both mitogen-activated protein kinase and p70 S6 kinase pathways

1 reference

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Understanding Ras: 'it ain't over 'til it's over'.

1 reference

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Restoration of tight junction structure and barrier function by down-regulation of the mitogen-activated protein kinase pathway in ras-transformed Madin-Darby canine kidney cells

1 reference

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Motility and invasion are differentially modulated by Rho family GTPases

1 reference

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The human non-muscle alpha-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cells

1 reference

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Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop

1 reference

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5 July 2018

Epidermal growth factor receptor activation of calpain is required for fibroblast motility and occurs via an ERK/MAP kinase signaling pathway

1 reference

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Cooperation between mDia1 and ROCK in Rho-induced actin reorganization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=65092

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Caldesmon inhibits nonmuscle cell contractility and interferes with the formation of focal adhesions

1 reference

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Putting a new twist on actin: ADF/cofilins modulate actin dynamics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=65092

5 July 2018

Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=65092

5 July 2018

Distinct actions and cooperative roles of ROCK and mDia in Rho small G protein-induced reorganization of the actin cytoskeleton in Madin-Darby canine kidney cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=65092

5 July 2018

Suppression of src-induced transformed phenotype by expression of tropomyosin-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=65092

5 July 2018

Transformation mediated by RhoA requires activity of ROCK kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=65092

5 July 2018

An essential part for Rho-associated kinase in the transcellular invasion of tumor cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=65092

5 July 2018

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=65092

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Possible involvement of the inactivation of the Rho-Rho-kinase pathway in oncogenic Ras-induced transformation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=65092

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Ras- and Raf-induced down-modulation of non-muscle tropomyosin are MEK-independent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=65092

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Activation of both MAP kinase and phosphatidylinositide 3-kinase by Ras is required for hepatocyte growth factor/scatter factor-induced adherens junction disassembly

1 reference

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Down-regulation of tropomyosin-2 expression in c-Jun-transformed rat fibroblasts involves induction of a MEK1-dependent autocrine loop

1 reference

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Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1.

1 reference

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Identification of a novel inhibitor of mitogen-activated protein kinase kinase

1 reference

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1 reference

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Rho-stimulated contractility contributes to the fibroblastic phenotype of Ras-transformed epithelial cells

1 reference

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Tropomyosin-2 cDNA lacking the 3' untranslated region riboregulator induces growth inhibition of v-Ki-ras-transformed fibroblasts

1 reference

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Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

1 reference

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1 reference

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Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase

1 reference

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Signal transduction from multiple Ras effectors

1 reference

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The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton

1 reference

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Forced expression of tropomyosin 2 or 3 in v-Ki-ras-transformed fibroblasts results in distinct phenotypic effects

1 reference

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1 reference

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A role for Rho in Ras transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=65092

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1 reference

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Expression of transduced tropomyosin 1 cDNA suppresses neoplastic growth of cells transformed by the ras oncogene

1 reference

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1 reference

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1 reference

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Restoration of microfilament bundle organization in v-raf-transformed NRK cells after transduction with tropomyosin 2 cDNA.

1 reference

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Multiple Ras functions can contribute to mammalian cell transformation

1 reference

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1 reference

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1 reference

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Differential expression of tropomyosin forms in the microfilaments isolated from normal and transformed rat cultured cells.

1 reference

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Differential modulation of actin-severing activity of gelsolin by multiple isoforms of cultured rat cell tropomyosin. Potentiation of protective ability of tropomyosins by 83-kDa nonmuscle caldesmon

1 reference

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1 reference

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Focal adhesion assembly

1 reference

https://pubmed.ncbi.nlm.nih.gov/11809843

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dynamin is required for the activation of mitogen-activated protein (MAP) kinase by MAP kinase kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/11809843

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11809843

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1091/MBC.01-06-0302

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

ResearchGate publication ID

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