(Q33964561)

English

An engineered PAX3-KRAB transcriptional repressor inhibits the malignant phenotype of alveolar rhabdomyosarcoma cells harboring the endogenous PAX3-FKHR oncogene

scientific article

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scholarly article

1 reference

Europe PubMed Central

30 July 2017

An engineered PAX3-KRAB transcriptional repressor inhibits the malignant phenotype of alveolar rhabdomyosarcoma cells harboring the endogenous PAX3-FKHR oncogene (English)

1 reference

Europe PubMed Central

30 July 2017

alveolar rhabdomyosarcoma

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

W J Fredericks

1

1 reference

Europe PubMed Central

30 July 2017

K Ayyanathan

2

1 reference

Europe PubMed Central

30 July 2017

M Herlyn

3

1 reference

Europe PubMed Central

30 July 2017

J R Friedman

4

1 reference

Europe PubMed Central

30 July 2017

F J Rauscher

5

1 reference

Europe PubMed Central

30 July 2017

language of work or name

0 references

publication date

1 July 2000

1 reference

Europe PubMed Central

30 July 2017

Molecular and Cellular Biology

1 reference

Europe PubMed Central

30 July 2017

20

1 reference

Europe PubMed Central

30 July 2017

14

1 reference

Europe PubMed Central

30 July 2017

5019-5031

1 reference

Europe PubMed Central

30 July 2017

Reconstitution of the KRAB-KAP-1 repressor complex: a model system for defining the molecular anatomy of RING-B box-coiled-coil domain-mediated protein-protein interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Regulation of the forkhead transcription factor FKHR, but not the PAX3-FKHR fusion protein, by the serine/threonine kinase Akt.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Cellular survival: a play in three Akts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

cDNA microarrays detect activation of a myogenic transcription program by the PAX3-FKHR fusion oncogene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Genes, chromosomes, and rhabdomyosarcoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Msx1 antagonizes the myogenic activity of Pax3 in migrating limb muscle precursors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Rhabdomyosarcoma--working out the pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Conservation of an insulin response unit between mouse and human glucose-6-phosphatase catalytic subunit gene promoters: transcription factor FKHR binds the insulin response sequence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Suppression of gene expression by tethering KRAB domain to promoter of ER target genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

The Pax3-FKHR oncoprotein is unresponsive to the Pax3-associated repressor hDaxx

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Krüppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Cellular actions of insulin-like growth factor binding proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Genetic and epigenetic control of muscle development in vertebrates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Regulation of hypaxial muscle development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Pax genes and their role in organogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Pax3 functions in cell survival and in pax7 regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Pax3 and Pax7 are expressed in commissural neurons and restrict ventral neuronal identity in the spinal cord

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Toward controlling gene expression at will: specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Gene expression profiling of alveolar rhabdomyosarcoma with cDNA microarrays.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

HIRA, a mammalian homologue of Saccharomyces cerevisiae transcriptional co-repressors, interacts with Pax3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Identification of a new binding motif for the paired domain of Pax-3 and unusual characteristics of spacing of bipartite recognition elements on binding and transcription activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Tumor-specific PAX3-FKHR transcription factor, but not PAX3, activates the platelet-derived growth factor alpha receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Pax-3 is necessary but not sufficient for lbx1 expression in myogenic precursor cells of the limb

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Interaction of the pRB-family proteins with factors containing paired-like homeodomains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Consequences of chromosomal abnormalities in tumor development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Pax genes and organogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Neural tube defects in embryos of diabetic mice: role of the Pax-3 gene and apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Ectopic Pax-3 activates MyoD and Myf-5 expression in embryonic mesoderm and neural tissue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Redefining the genetic hierarchies controlling skeletal myogenesis: Pax-3 and Myf-5 act upstream of MyoD.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Cell transformation mediated by homodimeric E2A-HLF transcription factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

The biologic function of PML and its role in acute promyelocytic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Induction of apoptosis in rhabdomyosarcoma cells through down-regulation of PAX proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

The hybrid PAX3-FKHR fusion protein of alveolar rhabdomyosarcoma transforms fibroblasts in culture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

KAP-1, a novel corepressor for the highly conserved KRAB repression domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Isolation of genes differentially expressed in human primary myoblasts and embryonal rhabdomyosarcoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Pax3 modulates expression of the c-Met receptor during limb muscle development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Pax-3 is necessary for migration but not differentiation of limb muscle precursors in the mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

A microplate assay for quantitation of anchorage-independent growth of transformed cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Krüppel-associated boxes are potent transcriptional repression domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Pax-3-DNA interaction: flexibility in the DNA binding and induction of DNA conformational changes by paired domains.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Molecular basis of splotch and Waardenburg Pax-3 mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Cooperative dimerization of paired class homeo domains on DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Pax-3 contains domains for transcription activation and transcription inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Insulin-like growth factor II overexpression in myoblasts induces phenotypic changes typical of the malignant phenotype.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Wild type PAX3 protein and the PAX3-FKHR fusion protein of alveolar rhabdomyosarcoma contain potent, structurally distinct transcriptional activation domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Molecular cloning and characterization of a human PAX-7 cDNA expressed in normal and neoplastic myocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

A specific chromosomal abnormality in rhabdomyosarcoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Pax-3, a novel murine DNA binding protein expressed during early neurogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

28 July 2018

Early specification of limb muscle precursor cells by the homeobox gene Lbx1h.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

29 October 2018

PAX3 and PAX7 exhibit conserved cis-acting transcription repression domains and utilize a common gain of function mechanism in alveolar rhabdomyosarcoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

29 October 2018

The role of SF/HGF and c-Met in the development of skeletal muscle.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

29 October 2018

Insulin-like growth factor II and PAX3-FKHR cooperate in the oncogenesis of rhabdomyosarcoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

29 October 2018

Reduced expression of pax-3 is associated with overexpression of cdc46 in the mouse embryo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

29 October 2018

Epistatic relationship between Waardenburg syndrome genes MITF and PAX3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

29 October 2018

Antisense-mediated reduction in insulin-like growth factor-I receptor expression suppresses the malignant phenotype of a human alveolar rhabdomyosarcoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

29 October 2018

PAX3 gene structure and mutations: close analogies between Waardenburg syndrome and the Splotch mouse.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

29 October 2018

Dual functions of the AML1/Evi-1 chimeric protein in the mechanism of leukemogenesis in t(3;21) leukemias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=85952

29 October 2018

Chromosomal abnormalities and tumor development: from genes to therapeutic mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/10866659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A molecular mechanism enabling continuous embryonic muscle growth - a balance between proliferation and differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/10866659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of chimeric paired box transcription factors in the pathogenesis of pediatric rhabdomysarcoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/10866659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myc oncogene expression and nude mouse tumorigenicity and metastasis formation are higher in alveolar than embryonal rhabdomyosarcoma cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/10866659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Retrogenic expression of the MET proto-oncogene correlates with the invasive phenotype of human rhabdomyosarcomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/10866659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FKHR Binds the Insulin Response Element in the Insulin-Like Growth Factor Binding Protein-1 Promoter1

1 reference

https://pubmed.ncbi.nlm.nih.gov/10866659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal skeletogenesis occurs coincident with increased apoptosis in the Splotch (Sp2H) mutant: putative roles for Pax3 and PDGFRalpha in rib patterning

1 reference

https://pubmed.ncbi.nlm.nih.gov/10866659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pax3 and Regulation of the Melanocyte-specific Tyrosinase-related Protein-1 Promoter

1 reference

https://pubmed.ncbi.nlm.nih.gov/10866659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor II acts as an autocrine growth and motility factor in human rhabdomyosarcoma tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/10866659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Up-regulation of MET but not neural cell adhesion molecule expression by the PAX3-FKHR fusion protein in alveolar rhabdomyosarcoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/10866659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MCB.20.14.5019-5031.2000

1 reference

Europe PubMed Central

30 July 2017

1 reference

Europe PubMed Central

30 July 2017

1 reference

Europe PubMed Central

30 July 2017

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