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DNA recognition by the herpes simplex virus transactivator VP16: a novel DNA-binding structure.
scientific article published in July 2001
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stated in
Europe PubMed Central
PMCID
87145
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11416146%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 November 2019
title
DNA recognition by the herpes simplex virus transactivator VP16: a novel DNA-binding structure
(English)
1 reference
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Europe PubMed Central
PMCID
87145
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11416146%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 November 2019
author
Winship Herr
series ordinal
4
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Europe PubMed Central
PMCID
87145
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11416146%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 November 2019
author name string
R Babb
series ordinal
1
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Europe PubMed Central
PMCID
87145
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11416146%20AND%20SRC:MED&resulttype=core&format=json
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8 November 2019
C C Huang
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2
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Europe PubMed Central
PMCID
87145
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11416146%20AND%20SRC:MED&resulttype=core&format=json
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8 November 2019
D J Aufiero
series ordinal
3
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87145
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8 November 2019
language of work or name
English
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publication date
1 July 2001
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Europe PubMed Central
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87145
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retrieved
8 November 2019
published in
Molecular and Cellular Biology
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stated in
Europe PubMed Central
PMCID
87145
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11416146%20AND%20SRC:MED&resulttype=core&format=json
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8 November 2019
volume
21
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Europe PubMed Central
PMCID
87145
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8 November 2019
page(s)
4700-4712
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Europe PubMed Central
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87145
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11416146%20AND%20SRC:MED&resulttype=core&format=json
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8 November 2019
issue
14
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stated in
Europe PubMed Central
PMCID
87145
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11416146%20AND%20SRC:MED&resulttype=core&format=json
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8 November 2019
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Crystal structure of the conserved core of the herpes simplex virus transcriptional regulatory protein VP16
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VP16 targets an amino-terminal domain of HCF involved in cell cycle progression
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Interdigitated residues within a small region of VP16 interact with Oct-1, HCF, and DNA
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A single serine residue at position 375 of VP16 is critical for complex assembly with Oct-1 and HCF and is a target of phosphorylation by casein kinase II
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A single-point mutation in HCF causes temperature-sensitive cell-cycle arrest and disrupts VP16 function.
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Folding of proteins with WD-repeats: comparison of six members of the WD-repeat superfamily to the G protein beta subunit.
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Conformational alteration of Oct-1 upon DNA binding dictates selectivity in differential interactions with related transcriptional coactivators
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The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2
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Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16)
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Differential positive control by Oct-1 and Oct-2: activation of a transcriptionally silent motif through Oct-1 and VP16 corecruitment
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The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor protein
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Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules
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Mechanisms for flexibility in DNA sequence recognition and VP16-induced complex formation by the Oct-1 POU domain
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The cellular C1 factor of the herpes simplex virus enhancer complex is a family of polypeptides
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Positive and negative regulation at the herpes simplex virus ICP4 and ICP0 TAATGARAT motifs
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The 65,000-Mr DNA-binding and virion trans-inducing proteins of herpes simplex virus type 1.
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The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain
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Direct combinatorial interaction between a herpes simplex virus regulatory protein and a cellular octamer-binding factor mediates specific induction of virus immediate-early gene expression
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5 July 2018
Activation of the U2 snRNA promoter by the octamer motif defines a new class of RNA polymerase II enhancer elements
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5 July 2018
Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression
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5 July 2018
A herpesvirus trans-activating protein interacts with transcription factor OTF-1 and other cellular proteins
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5 July 2018
The C-terminal 79 amino acids of the herpes simplex virus regulatory protein, Vmw65, efficiently activate transcription in yeast and mammalian cells in chimeric DNA-binding proteins
1 reference
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87145
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5 July 2018
The Oct-1 homoeodomain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16.
1 reference
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5 July 2018
The octamer-binding proteins form multi-protein--DNA complexes with the HSV alpha TIF regulatory protein
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5 July 2018
Overlapping octamer and TAATGARAT motifs in the VF65-response elements in herpes simplex virus immediate-early promoters represent independent binding sites for cellular nuclear factor III
1 reference
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87145
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5 July 2018
Structural requirements in the herpes simplex virus type 1 transactivator Vmw65 for interaction with the cellular octamer-binding protein and target TAATGARAT sequences.
1 reference
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87145
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5 July 2018
Differential transcriptional activation by Oct-1 and Oct-2: interdependent activation domains induce Oct-2 phosphorylation
1 reference
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5 July 2018
Characterization of a cellular factor which interacts functionally with Oct-1 in the assembly of a multicomponent transcription complex
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87145
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5 July 2018
A cellular factor binds to the herpes simplex virus type 1 transactivator Vmw65 and is required for Vmw65-dependent protein-DNA complex assembly with Oct-1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87145
retrieved
5 July 2018
Interactions of the Oct-1 POU subdomains with specific DNA sequences and with the HSV alpha-trans-activator protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87145
retrieved
5 July 2018
Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87145
retrieved
5 July 2018
The herpes simplex virus trans-activator VP16 recognizes the Oct-1 homeo domain: evidence for a homeo domain recognition subdomain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87145
retrieved
5 July 2018
A single amino acid exchange transfers VP16-induced positive control from the Oct-1 to the Oct-2 homeo domain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87145
retrieved
5 July 2018
Recognition of the surface of a homeo domain protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=87145
retrieved
5 July 2018
The POU domain is a bipartite DNA-binding structure
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/11416146
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Site-specific conformational alteration of the Oct-1 POU domain-DNA complex as the basis for differential recognition by Vmw65 (VP16)
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/11416146
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1128/MCB.21.14.4700-4712.2001
1 reference
stated in
Europe PubMed Central
PMCID
87145
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11416146%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 November 2019
PMCID
87145
1 reference
stated in
Europe PubMed Central
PMCID
87145
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11416146%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 November 2019
PubMed ID
11416146
1 reference
stated in
Europe PubMed Central
PMCID
87145
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11416146%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 November 2019
ResearchGate publication ID
11924375
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