(Q33984222)

30 July 2017

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title

Pharmacokinetics following intraventricular administration of chemotherapy in patients with neoplastic meningitis (English)

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30 July 2017

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Gudrun Fleischhack

1

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30 July 2017

Ulrich Jaehde

series ordinal

2

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30 July 2017

Udo Bode

series ordinal

3

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30 July 2017

publication date

1 January 2005

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Clinical Pharmacokinetics

30 July 2017

published in

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30 July 2017

volume

44

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30 July 2017

issue

1

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30 July 2017

page(s)

1-31

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Comparison of in vitro activity of epipodophyllotoxins with other chemotherapeutic agents in human medulloblastomas

30 July 2017

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Early intensification of intrathecal chemotherapy virtually eliminates central nervous system relapse in children with acute lymphoblastic leukemia

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Distribution of methotrexate in the cerebrospinal fluid and brain after intraventricular administration

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Multidrug resistance in brain tumors: roles of the blood-brain barrier

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Differences in cerebrospinal fluid penetration of corticosteroids: possible relationship to the prevention of meningeal leukemia

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Combination intraventricular chemotherapy for meningeal neoplasia.

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Chemotherapy as prophylaxis and treatment of meningosis in children less than 3 years of age with medulloblastoma.

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Pharmacokinetics of methotrexate in the cerebrospinal fluid after intracerebroventricular administration in patients with meningeal carcinomatosis and altered cerebrospinal fluid flow dynamics

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Potential central nervous system antitumor agents. Aziridinylbenzoquinones. 1

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12 December 2020

Carcinoma meningitis secondary to non-small cell lung cancer: combined modality therapy

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12 December 2020

Ventriculolumber perfusion of 3-[(4-amino-2-methyl-5-pyrimidinyl)-methyl]-1-(2-chloroethyl-1-nitrosou rea hydrochloride for subarachnoid dissemination of gliomas

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12 December 2020

Leptomeningeal carcinomatosis. Presenting features and prognostic factors.

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12 December 2020

Cytosine arabinoside cerebrospinal fluid kinetics

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12 December 2020

Activity of intrathecal 4-hydroperoxycyclophosphamide in a nude rat model of human neoplastic meningitis.

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12 December 2020

[Concept and interim result of the ALL-BFM 90 therapy study in treatment of acute lymphoblastic leukemia in children and adolescents: the significance of initial therapy response in blood and bone marrow]

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12 December 2020

Spinal 111Indium-DTPA CSF flow studies in leptomeningeal metastasis

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12 December 2020

Infiltration of the leptomeninges by systemic cancer. A clinical and pathologic study

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12 December 2020

Prophylaxis and treatment of neoplastic meningeosis in childhood acute lymphoblastic leukemia.

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12 December 2020

Intrathecal administration of 4-hydroperoxycyclophosphamide in rhesus monkeys.

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12 December 2020

Phase I/II study of intraventricular and intrathecal ACNU for leptomeningeal neoplasia

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12 December 2020

Intrathecal leucovorin after intrathecal methotrexate overdose

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12 December 2020

[Pharmacokinetics of intrathecal chemotherapy and clinical problems]

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12 December 2020

Subcutaneous reservoir and pump for sterile access to ventricular cerebrospinal fluid

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12 December 2020

Pharmacokinetics of intraventricular administration

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12 December 2020

Active transport of methotrexate from cerebrospinal fluid in humans

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12 December 2020

Leptomeningeal carcinomatosis

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12 December 2020

Normal brain development and aging: quantitative analysis at in vivo MR imaging in healthy volunteers.

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12 December 2020

Carcinomatous meningitis secondary to breast cancer: predictors of response to combined modality therapy

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12 December 2020

The current status of camptothecin analogues as antitumor agents

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12 December 2020

High-dose intravenous methotrexate for patients with nonleukemic leptomeningeal cancer: is intrathecal chemotherapy necessary?

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12 December 2020

Variability in the disposition of intraventricular methotrexate: a proposal for rational dosing

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12 December 2020

Purification and properties of carboxypeptidase G2 from Pseudomonas sp. strain RS-16. Use of a novel triazine dye affinity method

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12 December 2020

New aspects of clinical and cellular pharmacodynamics of methotrexate with special emphasis on its role in the treatment of acute lymphoblastic leukemia in children.

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12 December 2020

Meningeal carcinomatosis in breast cancer

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12 December 2020

Methotrexate, cytosine arabinoside, and BCNU concentration in brain after ventriculocisternal perfusion

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12 December 2020

Experimental chemotherapy of human medulloblastoma cell lines and transplantable xenografts with bifunctional alkylating agents

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12 December 2020

Uptake of bleomycin by human brain tumours

1 reference

12 December 2020

Intrathecal busulfan treatment of human neoplastic meningitis in athymic nude rats.

1 reference

12 December 2020

Pharmacokinetics of high-dose etoposide (VP-16-213) administered to cancer patients

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12 December 2020

Radioisotope CSF flow studies in leptomeningeal metastases

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12 December 2020

Accumulation of methotrexate in systemic tissues after intrathecal administration

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12 December 2020

Pharmacokinetics of cytosine arabinoside in cerebrospinal fluid and of its metabolite in leukemic cells.

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12 December 2020

Cerebrospinal fluid pharmacokinetics and penetration of continuous infusion topotecan in children with central nervous system tumors.

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12 December 2020

Treatment of neoplastic meningitis with intraventricular thiotepa and methotrexate

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12 December 2020

Analysis of patterns of care of brain tumor patients in the United States: a study of the Brain Tumor Section of the AANS and the CNS and the Commission on Cancer of the ACS.

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12 December 2020

Primary central nervous system lymphoma

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12 December 2020

Pharmacokinetics of Intralumbar DTC-101 for the Treatment of Leptomeningeal Metastases

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12 December 2020

Pharmacokinetics of intrathecal gemcitabine in nonhuman primates.

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12 December 2020

Meningeal carcinomatosis. Clinical manifestations

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12 December 2020

Ommaya reservoirs in 387 cancer patients: a 15-year experience

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12 December 2020

Experiences with the Ommaya reservoir for prophylaxis and treatment of the central nervous system in adult acute myelocytic leukemia

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12 December 2020

CT abnormalities and altered methotrexate clearance in children with CNS leukemia.

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12 December 2020

Primate Model for Long-Term Study of Intraventricularly or Intrathecally Administered Drugs and Intracranial Pressure

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12 December 2020

Intrathecal administration of topotecan in nonhuman primates

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12 December 2020

Ventriculolumbar perfusion chemotherapy with methotrexate and cytosine arabinoside for meningeal carcinomatosis: a pilot study in 13 patients

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12 December 2020

Randomized trial of a slow-release versus a standard formulation of cytarabine for the intrathecal treatment of lymphomatous meningitis.

1 reference

12 December 2020

Serum and cerebrospinal fluid distribution of 5-methyltetrahydrofolate after intravenous calcium leucovorin and intra-Ommaya methotrexate administration in patients with meningeal carcinomatosis

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12 December 2020

Intrathecal distribution of ACNU by various modes of its administration analyzed by HPLC and autoradiography

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12 December 2020

Primary central nervous system lymphoma: a clinicopathological study of 28 cases

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12 December 2020

High-dose methotrexate-citrovorum factor rescue in the management of brain tumors

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12 December 2020

Intrathecal chemotherapy with MX2 for treating glioma dissemination in vivo.

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12 December 2020

Alternative administration of camptothecin analogues

1 reference

12 December 2020

Comparison of cytosine arabinoside delivery to rat brain by intravenous, intrathecal, intraventricular and intraparenchymal routes of administration

1 reference

12 December 2020

Central nervous system metastasis in breast cancer

1 reference

12 December 2020

A pharmacokinetic model of topotecan clearance from plasma and cerebrospinal fluid.

1 reference

12 December 2020

Intracavitary chemotherapy of polycystic craniopharyngioma with bleomycin

1 reference

12 December 2020

Implantable pumps for drug delivery to the brain

1 reference

12 December 2020

Ventriculolumbar perfusion of 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitrosou rea hydrochloride.

1 reference

12 December 2020

Pharmacodynamics and the blood-brain barrier

1 reference

12 December 2020

Improvement in survival produced by sequential therapies in the treatment of recurrent medulloblastoma.

1 reference

12 December 2020

Mechanism of action of antitumor drug etoposide: a review

1 reference

12 December 2020

Clinical pharmacology of intrathecal methotrexate. I. Pharmacokinetics in nontoxic patients after lumbar injection

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12 December 2020

Intrathecal mafosfamide therapy for pediatric brain tumors with meningeal dissemination

1 reference

12 December 2020

Treatment for meningeal carcinomatosis in breast cancer

1 reference

12 December 2020

Intrathecal chemotherapy: brain tissue profiles after ventriculocisternal perfusion

1 reference

12 December 2020

Pharmacokinetics of methotrexate following intravenous and intraventricular administration in acute lymphocytic leukemia and non-Hodgkin's lymphoma

1 reference

12 December 2020

Pharmacokinetics and metabolism of cytosine arabinoside in the central nervous system.

1 reference

12 December 2020

Pharmacokinetics of intraventricular and intravenous N,N',N''-triethylenethiophosphoramide (thiotepa) in rhesus monkeys and humans.

1 reference

12 December 2020

Phase I/II trial and pharmacokinetics of intrathecal diaziquone in refractory meningeal malignancies

1 reference

12 December 2020

Primary brain tumors: review of etiology, diagnosis and treatment.

1 reference

12 December 2020

A randomized controlled trial comparing intrathecal sustained-release cytarabine (DepoCyt) to intrathecal methotrexate in patients with neoplastic meningitis from solid tumors

1 reference

12 December 2020

High-dose carboplatin, thiotepa, and etoposide with autologous stem-cell rescue for patients with recurrent medulloblastoma. Children's Cancer Group

1 reference

12 December 2020

Intrathecal 4-hydroperoxycyclophosphamide: neurotoxicity, cerebrospinal fluid pharmacokinetics, and antitumor activity in a rabbit model of VX2 leptomeningeal carcinomatosis

1 reference

12 December 2020

Antitumor effect and metabolic activation of cyclophosphamide and 4-hydroperoxycyclophosphamide in the human breast carcinoma (MX-1)-nude mouse system

1 reference

12 December 2020

Phase I and clinical pharmacological study of mercaptopurine administered as a prolonged intravenous infusion

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12 December 2020

Reservoir systems for intraventricular chemotherapy

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12 December 2020

Elimination of clonogenic Burkitt's lymphoma cells from human bone marrow using 4-hydroperoxycyclophosphamide in combination with monoclonal antibodies and complement

1 reference

12 December 2020

Pharmacokinetics and biochemical effects of a fatal intrathecal methotrexate overdose

1 reference

12 December 2020

New cytotoxic drugs for intrathecal administration

1 reference

12 December 2020

Combined systemic and intraventricular chemotherapy in primary CNS lymphoma: a pilot study

1 reference

12 December 2020

Pharmacokinetics of nimustine, methotrexate, and cytosine arabinoside during cerebrospinal fluid perfusion chemotherapy in patients with disseminated brain tumors

1 reference

12 December 2020

Clinical pharmacology of intrathecal methotrexate. II. An improved dosage regimen derived from age-related pharmacokinetics

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12 December 2020

Treatment of leukemia with large doses of methotrexate and folinic acid: clinical-biochemical correlates

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12 December 2020

Penetration of VP 16-213 into cerebrospinal fluid after high-dose intravenous administration

1 reference

12 December 2020

Long-term results of four consecutive trials in childhood ALL performed by the ALL-BFM study group from 1981 to 1995. Berlin-Frankfurt-Münster.

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12 December 2020

Pharmacologically directed ara-C therapy for refractory leukemia.

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12 December 2020

Reservoirs for Intraventricular Chemotherapy

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12 December 2020

Intrathecal administration of etoposide in the treatment of malignant meningitis: feasibility and pharmacokinetic data

1 reference

12 December 2020

Penetration of etoposide into human malignant brain tumors after intravenous and oral administration

1 reference

12 December 2020

Phase I clinical trial of intrathecal topotecan in patients with neoplastic meningitis

1 reference

12 December 2020

Meningeosis leukaemica in adult acute lymphoblastic leukaemia

1 reference

12 December 2020

Intraventricular versus intralumbar methotrexate for central-nervous-system leukemia: Prolonged remission with the ommaya reservoir

1 reference

12 December 2020

"Concentration x time" methotrexate via a subcutaneous reservoir: a less toxic regimen for intraventricular chemotherapy of central nervous system neoplasms

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12 December 2020

Reversible occlusion shunt for intraventricular chemotherapy in shunt-dependent brain tumor patients

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12 December 2020

The blood-brain barrier and oncology: new insights into function and modulation

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12 December 2020

Intrathecal methotrexate versus central nervous system leukemia

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12 December 2020

Methotrexate distribution within the subarachnoid space after intraventricular and intravenous administration

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12 December 2020

Distribution of kinase and deaminase of 1-beta-D-arabinofuranosylcytosine in tissues of man and mouse

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12 December 2020

The effect of-beta-D-arabinofuranosylcytosine on growth, viability, and DNA synthesis of mouse L-cells

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12 December 2020

Hypofractionated moderate dose radiation, intrathecal chemotherapy, and repetitive reinduction/reconsolidation systemic therapy for central nervous system relapse of acute lymphoblastic leukemia in children

1 reference

12 December 2020

The acute management of intrathecal methotrexate overdose: pharmacologic rationale and guidelines

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12 December 2020

Prognostic significance of coexistent bulky metastatic central nervous system disease in patients with leptomeningeal metastases

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12 December 2020

The pharmacokinetics of cytosine arabinoside in the plasma and cerebrospinal fluid during conventional and high-dose therapy

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12 December 2020

Weekly methotrexate-calcium leucovorin rescue: effect of alkalinization on nephrotoxicity; pharmacokinetics in the CNS; and use in CNS non-Hodgkin's lymphoma

1 reference

12 December 2020

Survival of patients with high grade glioma treated with intrathecal thiotriethylenephosphoramide for ependymal or leptomeningeal gliomatosis

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12 December 2020

Formation and absorption of cerebrospinal fluid in man

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12 December 2020

Unexpected in vitro chemosensitivity of malignant gliomas to 4-hydroxyperoxycyclophosphamide (4-HC).

1 reference

12 December 2020

Cerebrospinal fluid pharmacokinetics of intraventricular and intravenous aziridinylbenzoquinone

1 reference

12 December 2020

Rescue of experimental intrathecal methotrexate overdose with carboxypeptidase-G2.

1 reference

12 December 2020

6-Mercaptopurine in cerebrospinal fluid during oral maintenance therapy of children with acute lymphoblastic leukemia

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12 December 2020

Complications associated with intraventricular chemotherapy in patients with leptomeningeal metastases

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12 December 2020

Intracranial tumours in the first 18 months of life

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12 December 2020

Clinical results and pharmacokinetics of high-dose cytosine arabinoside (HD ARA-C)

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12 December 2020

10.2165/00003088-200544010-00001

Identifiers

DOI

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Dimensions Publication ID

30 July 2017

1015562806

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