(Q33984776)

30 July 2017

1 reference

title

Intrinsic disorder in the androgen receptor: identification, characterisation and drugability (English)

1 reference

30 July 2017

Iain J McEwan

1

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30 July 2017

5 August 2011

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30 July 2017

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30 July 2017

8

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30 July 2017

1

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30 July 2017

82-90

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Androgens and the male reproductive tract: an overview of classical roles and current perspectives.

30 July 2017

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Identification of androgen receptor phosphorylation in the primate ovary in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Molecular mechanisms of androgen receptor-mediated gene regulation: structure-function analysis of the AF-1 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Sex, drugs and gene expression: signalling by members of the nuclear receptor superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Nuclear receptors: one big family

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Structural evidence for ligand specificity in the binding domain of the human androgen receptor. Implications for pathogenic gene mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

A surface on the androgen receptor that allosterically regulates coactivator binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Distinct recognition modes of FXXLF and LXXLL motifs by the androgen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Compartmentalization of androgen receptor protein-protein interactions in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

The contribution of different androgen receptor domains to receptor dimerization and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Structural basis of androgen receptor binding to selective androgen response elements.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

DNA recognition by nuclear receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Cell- and gene-specific regulation of primary target genes by the androgen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Transcriptional profiling of androgen receptor (AR) mutants suggests instructive and permissive roles of AR signaling in germ cell development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

New androgen receptor genomic targets show an interaction with the ETS1 transcription factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

DNA Binding Site Sequence Directs Glucocorticoid Receptor Structure and Activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Regulation of the amino-terminal transcription activation domain of progesterone receptor by a cofactor-induced protein folding mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Evolution of the primate androgen receptor: a structural basis for disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Consequences of poly-glutamine repeat length for the conformation and folding of the androgen receptor amino-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

The androgen receptor interacts with multiple regions of the large subunit of general transcription factor TFIIF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Role of conserved hydrophobic amino acids in androgen receptor AF-1 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Identification of two transcription activation units in the N-terminal domain of the human androgen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Interaction of the human androgen receptor transactivation function with the general transcription factor TFIIF

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Functional characterization of the native NH2-terminal transactivation domain of the human androgen receptor: binding kinetics for interactions with TFIIF and SRC-1a

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Structure and function of steroid receptor AF1 transactivation domains: induction of active conformations

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Structural basis for the nuclear import of the human androgen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Conformational analysis of the androgen receptor amino-terminal domain involved in transactivation. Influence of structure-stabilizing solutes and protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Induced alpha-helix structure in AF1 of the androgen receptor upon binding transcription factor TFIIF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Structural characterization of the native NH2-terminal transactivation domain of the human androgen receptor: a collapsed disordered conformation underlies structural plasticity and protein-induced folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Intra-domain communication between the N-terminal and DNA-binding domains of the androgen receptor: modulation of androgen response element DNA binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Intrinsically unstructured proteins and their functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

The interplay between structure and function in intrinsically unstructured proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Intrinsic disorder in transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Intrinsic disorder as a mechanism to optimize allosteric coupling in proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Androgen receptor phosphorylation. Regulation and identification of the phosphorylation sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Site-specific androgen receptor serine phosphorylation linked to epidermal growth factor-dependent growth of castration-recurrent prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Cell-specific regulation of androgen receptor phosphorylation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Phosphorylation of the androgen receptor is associated with reduced survival in hormone-refractory prostate cancer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing hormone-dependent transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Acetylation of androgen receptor enhances coactivator binding and promotes prostate cancer cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Regulation of the androgen receptor by SET9-mediated methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Lysine methylation and functional modulation of androgen receptor by Set9 methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

The androgen receptor acetylation site regulates cAMP and AKT but not ERK-induced activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Androgen receptor acetylation site mutations cause trafficking defects, misfolding, and aggregation similar to expanded glutamine tracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Glucocorticoid receptor phosphorylation differentially affects target gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Site-specific phosphorylation induces functionally active conformation in the intrinsically disordered N-terminal activation function (AF1) domain of the glucocorticoid receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

The phosphorylation of the androgen receptor by TFIIH directs the ubiquitin/proteasome process

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Covalent modification of the androgen receptor by small ubiquitin-like modifier 1 (SUMO-1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Differential effect of small ubiquitin-like modifier (SUMO)-ylation of the androgen receptor in the control of cooperativity on selective versus canonical response elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

A common motif within the negative regulatory regions of multiple factors inhibits their transcriptional synergy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Molecular mechanisms of castration-resistant prostate cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Molecular determinants of resistance to antiandrogen therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Mutation of histidine 874 in the androgen receptor ligand-binding domain leads to promiscuous ligand activation and altered p160 coactivator interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Development of a second-generation antiandrogen for treatment of advanced prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Development of androgen receptor antagonists with promising activity in castration-resistant prostate cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

The natural compounds atraric acid and N-butylbenzene-sulfonamide as antagonists of the human androgen receptor and inhibitors of prostate cancer cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Green tea polyphenol EGCG blunts androgen receptor function in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Androgen receptor decoy molecules block the growth of prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Sintokamides A to E, chlorinated peptides from the sponge Dysidea sp. that inhibit transactivation of the N-terminus of the androgen receptor in prostate cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Expression of androgen receptor splice variants in prostate cancer bone metastases is associated with castration-resistance and short survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Mechanism of antiandrogen action: conformational changes of the receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Mechanism of androgen receptor antagonism by bicalutamide in the treatment of prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

NBBS isolated from Pygeum africanum bark exhibits androgen antagonistic activity, inhibits AR nuclear translocation and prostate cancer cell growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

Non-competitive androgen receptor inhibition in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MB05249G

21 January 2018

Identifiers

DOI

10.1039/C1MB05249G

1 reference

30 July 2017

1 reference

PubMed ID

21822504