(Q33996985)

English

EGF receptor exposed to oxidative stress acquires abnormal phosphorylation and aberrant activated conformation that impairs canonical dimerization

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scholarly article

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21853092%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

EGF receptor exposed to oxidative stress acquires abnormal phosphorylation and aberrant activated conformation that impairs canonical dimerization (English)

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11 February 2020

phosphorylation

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based on heuristic

inferred from title

1

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11 February 2020

author name string

Elaine M Khan

2

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11 February 2020

Emiliana Tognon

3

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11 February 2020

Cathleen Becker

4

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11 February 2020

Majid Ashfaq

5

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11 February 2020

Tommer Ravid

6

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11 February 2020

Tzipora Goldkorn

7

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11 February 2020

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publication date

10 August 2011

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11 February 2020

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11 February 2020

6

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11 February 2020

8

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11 February 2020

e23240

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11 February 2020

copyright license

Creative Commons Attribution 4.0 International

10 August 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

Oxidative stress, inflammation, and cancer: how are they linked?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

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Kinase-mediated quasi-dimers of EGFR

1 reference

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5 July 2018

Lung injury and cancer: Mechanistic insights into ceramide and EGFR signaling under cigarette smoke

1 reference

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5 July 2018

Ceramide in Pseudomonas aeruginosa infections and cystic fibrosis

1 reference

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5 July 2018

Vascular barrier regulation by PAF, ceramide, caveolae, and NO - an intricate signaling network with discrepant effects in the pulmonary and systemic vasculature

1 reference

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5 July 2018

Neutral sphingomyelinase 2: a novel target in cigarette smoke-induced apoptosis and lung injury.

1 reference

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5 July 2018

The SRC family of protein tyrosine kinases: a new and promising target for colorectal cancer therapy.

1 reference

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5 July 2018

Spatial control of EGF receptor activation by reversible dimerization on living cells

1 reference

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5 July 2018

EGFR signaling and drug discovery.

1 reference

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5 July 2018

Neutral sphingomyelinase 2 (nSMase2) is a phosphoprotein regulated by calcineurin (PP2B)

1 reference

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5 July 2018

Novel mutant-selective EGFR kinase inhibitors against EGFR T790M

1 reference

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5 July 2018

Aberrant trafficking of NSCLC-associated EGFR mutants through the endocytic recycling pathway promotes interaction with Src.

1 reference

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5 July 2018

Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

The Juxtamembrane Region of the EGF Receptor Functions as an Activation Domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

Neutral sphingomyelinase 2 is activated by cigarette smoke to augment ceramide-induced apoptosis in lung cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

The role of cooperativity with Src in oncogenic transformation mediated by non-small cell lung cancer-associated EGF receptor mutants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

Effects of ceramide and other simple sphingolipids on membrane lateral structure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

Targeting epidermal growth factor receptor and SRC pathways in head and neck cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

EGFR tyrosine kinase inhibitors for the treatment of NSCLC in East Asia: present and future

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

Structure and clinical relevance of the epidermal growth factor receptor in human cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

Epidermal growth factor receptor exposed to cigarette smoke is aberrantly activated and undergoes perinuclear trafficking

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

Suppression of epidermal growth factor receptor signaling by protein kinase C-alpha activation requires CD82, caveolin-1, and ganglioside

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

Effect of ceramide N-acyl chain and polar headgroup structure on the properties of ordered lipid domains (lipid rafts).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

Reactive nitrogen and oxygen species activate different sphingomyelinases to induce apoptosis in airway epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor Sensitivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

nSMase2 activation and trafficking are modulated by oxidative stress to induce apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

Ligand-independent activation of the EGFR by lipid raft disruption

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

Epidermal growth factor receptor exposed to oxidative stress undergoes Src- and caveolin-1-dependent perinuclear trafficking

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

Receptor-type protein-tyrosine phosphatase-kappa regulates epidermal growth factor receptor function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

The c-Src tyrosine kinase associates with the catalytic domain of ErbB-2: implications for ErbB-2 mediated signaling and transformation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

Epidermal growth factor receptor dimerization and activation require ligand-induced conformational changes in the dimer interface

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

ERBB receptors and cancer: the complexity of targeted inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

EGFR mutation and resistance of non-small-cell lung cancer to gefitinib

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

Adhesion-mediated squamous cell carcinoma survival through ligand-independent activation of epidermal growth factor receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

Cholesterol depletion increases membrane stiffness of aortic endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

c-Cbl-mediated ubiquitinylation is required for epidermal growth factor receptor exit from the early endosomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

Raft ceramide in molecular medicine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

Role of the ErbB-4 carboxyl terminus in gamma-secretase cleavage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

Ligand-induced, receptor-mediated dimerization and activation of EGF receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

Cholesterol levels modulate EGF receptor-mediated signaling by altering receptor function and trafficking

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

Ligand-independent dimer formation of epidermal growth factor receptor (EGFR) is a step separable from ligand-induced EGFR signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

Clustering of CD40 ligand is required to form a functional contact with CD40.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

Ceramide-mediated apoptosis in lung epithelial cells is regulated by glutathione

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

Induction of topoisomerase II activity after ErbB2 activation is associated with a differential response to breast cancer chemotherapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

Epidermal growth factor-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase

1 reference

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5 July 2018

Untangling the ErbB signalling network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

Cell signaling by receptor tyrosine kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

Ceramide path in human lung cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154401

5 July 2018

Reversible inactivation of protein-tyrosine phosphatase 1B in A431 cells stimulated with epidermal growth factor

1 reference

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5 July 2018

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0023240

21 January 2018

EGFR activation coupled to inhibition of tyrosine phosphatases causes lateral signal propagation

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0023240

21 January 2018

Sphingomyelinase activity causes transbilayer lipid translocation in model and cell membranes.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0023240

21 January 2018

Platelet-activating factor reduces endothelial nitric oxide production: role of acid sphingomyelinase

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0023240

21 January 2018

Ceramide causes pulmonary cell apoptosis and emphysema: a role for sphingolipid homeostasis in the maintenance of alveolar cells.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0023240

21 January 2018

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1 reference

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29 October 2018

H2O2 acts on cellular membranes to generate ceramide signaling and initiate apoptosis in tracheobronchial epithelial cells

1 reference

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29 October 2018

Ceramide-rich membrane rafts mediate CD40 clustering

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853092

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Demonstration of epidermal growth factor-induced receptor dimerization in living cells using a chemical covalent cross-linking agent

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853092

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific and reversible inactivation of protein tyrosine phosphatases by hydrogen peroxide: evidence for a sulfenic acid intermediate and implications for redox regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853092

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0023240

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21853092%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

2011PLoSO...623240F

0 references

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21853092%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21853092%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

ResearchGate publication ID

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