(Q34010632)

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Generation of an activating Zn(2+) switch in the dopamine transporter: mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle

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scholarly article

1 reference

Europe PubMed Central

30 July 2017

Generation of an activating Zn(2+) switch in the dopamine transporter: mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle (English)

1 reference

Europe PubMed Central

30 July 2017

author name string

Claus Juul Loland

1

1 reference

Europe PubMed Central

30 July 2017

Lene Norregaard

2

1 reference

Europe PubMed Central

30 July 2017

Thomas Litman

3

1 reference

Europe PubMed Central

30 July 2017

Ulrik Gether

4

1 reference

Europe PubMed Central

30 July 2017

language of work or name

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publication date

29 January 2002

1 reference

Europe PubMed Central

30 July 2017

Proceedings of the National Academy of Sciences of the United States of America

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Europe PubMed Central

30 July 2017

99

1 reference

Europe PubMed Central

30 July 2017

3

1 reference

Europe PubMed Central

30 July 2017

1683-1688

1 reference

Europe PubMed Central

30 July 2017

The role of conserved tryptophan and acidic residues in the human dopamine transporter as characterized by site-directed mutagenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122251

5 July 2018

Biogenic amine transporters: regulation in flux

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122251

5 July 2018

Uncovering molecular mechanisms involved in activation of G protein-coupled receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122251

5 July 2018

Permeation and gating residues in serotonin transporter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122251

5 July 2018

Transport-dependent accessibility of a cytoplasmic loop cysteine in the human dopamine transporter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122251

5 July 2018

Regulated trafficking of the human dopamine transporter. Clathrin-mediated internalization and lysosomal degradation in response to phorbol esters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122251

5 July 2018

Catechol-O-methyltransferase activity in CHO cells expressing norepinephrine transporter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122251

5 July 2018

Analysis of zinc binding sites in protein crystal structures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122251

5 July 2018

Cocaine alters the accessibility of endogenous cysteines in putative extracellular and intracellular loops of the human dopamine transporter.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122251

5 July 2018

Structural instability of a constitutively active G protein-coupled receptor. Agonist-independent activation due to conformational flexibility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122251

5 July 2018

Protein kinase C activation regulates human serotonin transporters in HEK-293 cells via altered cell surface expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122251

5 July 2018

Differential reinforcing effects of cocaine and GBR-12909: biochemical evidence for divergent neuroadaptive changes in the mesolimbic dopaminergic system.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122251

5 July 2018

Bicistronic vector for the creation of stable mammalian cell lines that predisposes all antibiotic-resistant cells to express recombinant protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122251

5 July 2018

Molecular characterization of the dopamine transporter.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122251

5 July 2018

Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122251

5 July 2018

Neurotransmitter transporters: recent progress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122251

5 July 2018

Inverse agonist activity of beta-adrenergic antagonists.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122251

5 July 2018

Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the beta 2-adrenoceptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122251

5 July 2018

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122251

5 July 2018

Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122251

5 July 2018

Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122251

5 July 2018

Stable expression of high affinity NK1 (substance P) and NK2 (neurokinin A) receptors but low affinity NK3 (neurokinin B) receptors in transfected CHO cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122251

5 July 2018

Delineation of an endogenous zinc-binding site in the human dopamine transporter

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.032386299

21 January 2018

Defining proximity relationships in the tertiary structure of the dopamine transporter. Identification of a conserved glutamic acid as a third coordinate in the endogenous Zn(2+)-binding site.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.032386299

21 January 2018

Biosynthesis of peptide precursors and protease inhibitors using new constitutive and inducible eukaryotic expression vectors.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.032386299

21 January 2018

Protein sorting by tyrosine-based signals: adapting to the Ys and wherefores.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.032386299

21 January 2018

Engineered Zn(2+) switches in the gamma-aminobutyric acid (GABA) transporter-1. Differential effects on GABA uptake and currents

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.032386299

21 January 2018

A conformationally sensitive residue on the cytoplasmic surface of serotonin transporter

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.032386299

21 January 2018

Dopamine transporter expression confers cytotoxicity to low doses of the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122251

29 October 2018

Determination of external loop topology in the serotonin transporter by site-directed chemical labeling

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.032386299

21 January 2018

Structural probing of a microdomain in the dopamine transporter by engineering of artificial Zn2+ binding sites

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.032386299

21 January 2018

Constitutive activation of the beta2 adrenergic receptor alters the orientation of its sixth membrane-spanning segment

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.032386299

21 January 2018

Mutation of arginine 44 of GAT-1, a (Na(+) + Cl(-))-coupled gamma-aminobutyric acid transporter from rat brain, impairs net flux but not exchange

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.032386299

21 January 2018

Identifiers

10.1073/PNAS.032386299

1 reference

Europe PubMed Central

30 July 2017

2002PNAS...99.1683L

0 references

1 reference

Europe PubMed Central

30 July 2017

1 reference

Europe PubMed Central

30 July 2017

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