(Q34011254)

30 July 2017

Zebrafish Ext2 is necessary for Fgf and Wnt signaling, but not for Hh signaling (English)

1 reference

30 July 2017

0 references

Sabine Fischer

1

1 reference

30 July 2017

Beata Filipek-Gorniok

series ordinal

2

1 reference

30 July 2017

Johan Ledin

series ordinal

3

1 reference

30 July 2017

5 September 2011

1 reference

BMC Developmental Biology

30 July 2017

1 reference

30 July 2017

11

1 reference

30 July 2017

53

1 reference

https://scigraph.springernature.com/pub.10.1186/1471-213x-11-53

30 July 2017

0 references

cites work

Extracellular interactome of the FGF receptor-ligand system: complexities and the relative simplicity of the worm

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Regulation of zebrafish skeletogenesis by ext2/dackel and papst1/pinscher

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Contribution of EXT1, EXT2, and EXTL3 to heparan sulfate chain elongation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

The function of a Drosophila glypican does not depend entirely on heparan sulfate modification

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

The molecular diversity of glycosaminoglycans shapes animal development.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Mice deficient in Ext2 lack heparan sulfate and develop exostoses

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Heparan sulphate proteoglycans: the sweet side of development

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Cerebral hypoplasia and craniofacial defects in mice lacking heparan sulfate Ndst1 gene function

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Hedgehog signalling and the specification of muscle cell identity in the zebrafish embryo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Lipoprotein particles are required for Hedgehog and Wingless signalling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Distinct tissue-specificity of three zebrafish ext1 genes encoding proteoglycan modifying enzymes and their relationship to somitic Sonic hedgehog signaling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Functions of heparan sulfate proteoglycans in cell signaling during development

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Divide et Impera--the midbrain-hindbrain boundary and its organizer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Role of glycosylation in development

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Spatial and temporal expression of heparan sulfate in mouse development regulates FGF and FGF receptor assembly

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Mammalian Brain Morphogenesis and Midline Axon Guidance Require Heparan Sulfate

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Heparan sulfate proteoglycan modulation of developmental signaling in Drosophila

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Order out of chaos: assembly of ligand binding sites in heparan sulfate

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Wingful, an extracellular feedback inhibitor of Wingless

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Morpholino phenocopies of the swirl, snailhouse, somitabun, minifin, silberblick, and pipetail mutations

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Fibroblast growth factors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Effective targeted gene 'knockdown' in zebrafish

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Patterning of the zebrafish retina by a wave of sonic hedgehog activity.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Disruption of gastrulation and heparan sulfate biosynthesis in EXT1-deficient mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Functions of cell surface heparan sulfate proteoglycans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Ace/Fgf8 is required for forebrain commissure formation and patterning of the telencephalon.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

FGFs, heparan sulfate and FGFRs: complex interactions essential for development

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Structural basis for FGF receptor dimerization and activation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Characterisation of a second patched gene in the zebrafish Danio rerio and the differential response of patched genes to Hedgehog signalling.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Matrix proteoglycans: from molecular design to cellular function

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Sonic hedgehog is not required for the induction of medial floor plate cells in the zebrafish.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

The putative tumour suppressor EXT1 alters the expression of cell-surface heparan sulfate

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Mutations disrupting the ordering and topographic mapping of axons in the retinotectal projection of the zebrafish, Danio rerio.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Domain structure of heparan sulfates from bovine organs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Coordinate embryonic expression of three zebrafish engrailed genes.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Essential role of glycosaminoglycans in Fgf signaling during mouse gastrulation.

5 July 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-53

Glypican 4 modulates FGF signalling and regulates dorsoventral forebrain patterning in Xenopus embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-53

Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-53

The zebrafish glypican knypek controls cell polarity during gastrulation movements of convergent extension

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-53

Role of glypican 4 in the regulation of convergent extension movements during gastrulation in Xenopus laevis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-53

Processing by proprotein convertases is required for glypican-3 modulation of cell survival, Wnt signaling, and gastrulation movements

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-53

The glypican Dally-like is required for Hedgehog signalling in the embryonic epidermis of Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-53

Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-53

Lipoprotein-heparan sulfate interactions in the Hh pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-53

Ext1-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossification

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-53

Axon sorting in the optic tract requires HSPG synthesis by ext2 (dackel) and extl3 (boxer).

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-53

Tight transcriptional control of the ETS domain factors Erm and Pea3 by Fgf signaling during early zebrafish development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-53

Zebrafish pea3 and erm are general targets of FGF8 signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-53

Zebrafish fgf24 functions with fgf8 to promote posterior mesodermal development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-53

The zebrafish fgf24 mutant identifies an additional level of Fgf signaling involved in vertebrate forelimb initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-53

Sonic hedgehog, secreted by amacrine cells, acts as a short-range signal to direct differentiation and lamination in the zebrafish retina

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-53

Multiple muscle cell identities induced by distinct levels and timing of hedgehog activity in the zebrafish embryo

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-53

Regulatory gene expression boundaries demarcate sites of neuronal differentiation in the embryonic zebrafish forebrain

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-11-53

Bud specific N-sulfation of heparan sulfate regulates Shp2-dependent FGF signaling during lacrimal gland induction

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Enzymatically active N-deacetylase/N-sulfotransferase-2 is present in liver but does not contribute to heparan sulfate N-sulfation.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

HSPG synthesis by zebrafish Ext2 and Extl3 is required for Fgf10 signalling during limb development

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

The limb identity gene Tbx5 promotes limb initiation by interacting with Wnt2b and Fgf10.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Large, tissue-regulated domain diversity of heparan sulfates demonstrated by phage display antibodies

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Heparan sulfate proteoglycans are critical for the organization of the extracellular distribution of Wingless

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

dackel acts in the ectoderm of the zebrafish pectoral fin bud to maintain AER signaling

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Heparan sulfate proteoglycans are essential for FGF receptor signaling during Drosophila embryonic development

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesis

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

The Drosophila sugarless gene modulates Wingless signaling and encodes an enzyme involved in polysaccharide biosynthesis.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Jaw and branchial arch mutants in zebrafish II: anterior arches and cartilage differentiation

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Jaw and branchial arch mutants in zebrafish I: branchial arches.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Genetic analysis of fin formation in the zebrafish, Danio rerio

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Mutations affecting development of the zebrafish inner ear and lateral line.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

Analysis of FGF function in normal and no tail zebrafish embryos reveals separate mechanisms for formation of the trunk and the tail.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3183004

EXT1 regulates chondrocyte proliferation and differentiation during endochondral bone development

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21892940

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Heparan sulfate structure in mice with genetically modified heparan sulfate production

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21892940

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/1471-213X-11-53

1 reference

Dimensions Publication ID

30 July 2017

0 references

1 reference

30 July 2017

1 reference