(Q34033417)

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High-resolution chromatography/time-of-flight MSE with in silico data mining is an information-rich approach to reactive metabolite screening

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

High-resolution chromatography/time-of-flight MSE with in silico data mining is an information-rich approach to reactive metabolite screening (English)

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

1 reference

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based on heuristic

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author name string

Joanna E Barbara

1

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Jose M Castro-Perez

2

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

publication date

1 October 2011

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Europe PubMed Central

PubMed publication ID

30 July 2017

Rapid Communications in Mass Spectrometry

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Europe PubMed Central

PubMed publication ID

30 July 2017

25

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Europe PubMed Central

PubMed publication ID

30 July 2017

20

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

3029-3040

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Cyanide trapping of iminium ion reactive intermediates followed by detection and structure identification using liquid chromatography-tandem mass spectrometry (LC-MS/MS).

1 reference

https://api.crossref.org/works/10.1002%2FRCM.5197

21 January 2018

In vitro screening techniques for reactive metabolites for minimizing bioactivation potential in drug discovery

1 reference

https://api.crossref.org/works/10.1002%2FRCM.5197

21 January 2018

Managing the challenge of chemically reactive metabolites in drug development.

1 reference

https://api.crossref.org/works/10.1002%2FRCM.5197

21 January 2018

Detecting and characterizing reactive metabolites by liquid chromatography/tandem mass spectrometry

1 reference

https://api.crossref.org/works/10.1002%2FRCM.5197

21 January 2018

Mechanism-based inactivation of human cytochromes p450s: experimental characterization, reactive intermediates, and clinical implications

1 reference

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21 January 2018

Drug-protein adducts: an industry perspective on minimizing the potential for drug bioactivation in drug discovery and development

1 reference

https://api.crossref.org/works/10.1002%2FRCM.5197

21 January 2018

Rapid detection and characterization of in vitro and urinary N-acetyl-L-cysteine conjugates using quadrupole-linear ion trap mass spectrometry and polarity switching.

1 reference

https://api.crossref.org/works/10.1002%2FRCM.5197

21 January 2018

Reactive intermediates and the dynamics of glutathione transferases

1 reference

https://api.crossref.org/works/10.1002%2FRCM.5197

21 January 2018

A generic method to detect electrophilic intermediates using isotopic pattern triggered data-dependent high-resolution accurate mass spectrometry

1 reference

https://api.crossref.org/works/10.1002%2FRCM.5197

21 January 2018

A high-throughput liquid chromatography/tandem mass spectrometry method for screening glutathione conjugates using exact mass neutral loss acquisition

1 reference

https://api.crossref.org/works/10.1002%2FRCM.5197

21 January 2018

Negative ion tandem mass spectrometry for the detection of glutathione conjugates

1 reference

https://api.crossref.org/works/10.1002%2FRCM.5197

21 January 2018

Dual negative precursor ion scan approach for rapid detection of glutathione conjugates using liquid chromatography/tandem mass spectrometry

1 reference

https://api.crossref.org/works/10.1002%2FRCM.5197

21 January 2018

The development of a higher throughput reactive intermediate screening assay incorporating micro-bore liquid chromatography-micro-electrospray ionization-tandem mass spectrometry and glutathione ethyl ester as an in vitro conjugating agent

1 reference

https://api.crossref.org/works/10.1002%2FRCM.5197

21 January 2018

A liquid chromatography/tandem mass spectrometry method for detecting UGT-mediated bioactivation of drugs as their N-acetylcysteine adducts in human liver microsomes.

1 reference

https://api.crossref.org/works/10.1002%2FRCM.5197

21 January 2018

High-throughput screening and characterization of reactive metabolites using polarity switching of hybrid triple quadrupole linear ion trap mass spectrometry

1 reference

https://api.crossref.org/works/10.1002%2FRCM.5197

21 January 2018

Rapid detection and characterization of reactive drug metabolites in vitro using several isotope-labeled trapping agents and ultra-performance liquid chromatography/time-of-flight mass spectrometry

1 reference

https://api.crossref.org/works/10.1002%2FRCM.5197

21 January 2018

Quantitative-qualitative data acquisition using a benchtop Orbitrap mass spectrometer

1 reference

https://api.crossref.org/works/10.1002%2FRCM.5197

21 January 2018

'All-in-one' analysis for metabolite identification using liquid chromatography/hybrid quadrupole time-of-flight mass spectrometry with collision energy switching

1 reference

https://api.crossref.org/works/10.1002%2FRCM.5197

21 January 2018

Increasing throughput and information content for in vitro drug metabolism experiments using ultra-performance liquid chromatography coupled to a quadrupole time-of-flight mass spectrometer

1 reference

https://api.crossref.org/works/10.1002%2FRCM.5197

21 January 2018

Mass defect filter technique and its applications to drug metabolite identification by high-resolution mass spectrometry

1 reference

https://api.crossref.org/works/10.1002%2FRCM.5197

21 January 2018

Detection and structural characterization of glutathione-trapped reactive metabolites using liquid chromatography-high-resolution mass spectrometry and mass defect filtering.

1 reference

https://api.crossref.org/works/10.1002%2FRCM.5197

21 January 2018

Investigation of bioactivation of ticlopidine using linear ion trap/orbitrap mass spectrometry and an improved mass defect filtering technique

1 reference

https://api.crossref.org/works/10.1002%2FRCM.5197

21 January 2018

Accelerated throughput metabolic route screening in early drug discovery using high-resolution liquid chromatography/quadrupole time-of-flight mass spectrometry and automated data analysis

1 reference

https://api.crossref.org/works/10.1002%2FRCM.5197

21 January 2018

Generic dealkylation: a tool for increasing the hit-rate of metabolite rationalization, and automatic customization of mass defect filters

1 reference

https://api.crossref.org/works/10.1002%2FRCM.5197

21 January 2018

Bioactivation of the nontricyclic antidepressant nefazodone to a reactive quinone-imine species in human liver microsomes and recombinant cytochrome P450 3A4.

1 reference

https://api.crossref.org/works/10.1002%2FRCM.5197

21 January 2018

Combretastatin A4 phosphate: background and current clinical status

1 reference

https://api.crossref.org/works/10.1002%2FRCM.5197

21 January 2018

When should clozapine be initiated in schizophrenia?: Some arguments for and against earlier use of clozapine

1 reference

https://api.crossref.org/works/10.1002%2FRCM.5197

21 January 2018

NADPH-dependent covalent binding of [3H]paroxetine to human liver microsomes and S-9 fractions: identification of an electrophilic quinone metabolite of paroxetine

1 reference

https://api.crossref.org/works/10.1002%2FRCM.5197

21 January 2018

Identifiers

10.1002/RCM.5197

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

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