(Q34045687)

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Activity of Bruton's tyrosine-kinase inhibitor ibrutinib in patients with CD117-positive acute myeloid leukaemia: a mechanistic study using patient-derived blast cells

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scholarly article

1 reference

Europe PubMed Central

30 July 2017

Activity of Bruton's tyrosine-kinase inhibitor ibrutinib in patients with CD117-positive acute myeloid leukaemia: a mechanistic study using patient-derived blast cells (English)

1 reference

Europe PubMed Central

30 July 2017

1 reference

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inferred from title

1 reference

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inferred from title

Stuart A Rushworth

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26688095%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Rachel E Piddock

4

1 reference

Europe PubMed Central

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9 June 2020

David J MacEwan

9

1 reference

Europe PubMed Central

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9 June 2020

Kristian Bowles

10

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26688095%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

author name string

Genevra Pillinger

2

1 reference

Europe PubMed Central

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9 June 2020

Amina Abdul-Aziz

3

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26688095%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Manar S Shafat

5

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26688095%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Megan Y Murray

6

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26688095%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Lyubov Zaitseva

7

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26688095%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Matthew J Lawes

8

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26688095%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

publication date

14 April 2015

1 reference

Europe PubMed Central

30 July 2017

The Lancet. Haematology.

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26688095%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

2

1 reference

Europe PubMed Central

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9 June 2020

5

1 reference

Europe PubMed Central

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9 June 2020

e204-11

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26688095%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

The origin and evolution of mutations in acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS2352-3026%2815%2900046-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Common and overlapping oncogenic pathways contribute to the evolution of acute myeloid leukemias

1 reference

https://api.crossref.org/works/10.1016%2FS2352-3026%2815%2900046-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The kinase Btk negatively regulates the production of reactive oxygen species and stimulation-induced apoptosis in human neutrophils

1 reference

https://api.crossref.org/works/10.1016%2FS2352-3026%2815%2900046-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Bruton's tyrosine kinase is required for TLR2 and TLR4-induced TNF, but not IL-6, production

1 reference

https://api.crossref.org/works/10.1016%2FS2352-3026%2815%2900046-0

7 January 2021

based on heuristic

inferred from DOI database lookup

BTK inhibitor ibrutinib is cytotoxic to myeloma and potently enhances bortezomib and lenalidomide activities through NF-κB.

1 reference

https://api.crossref.org/works/10.1016%2FS2352-3026%2815%2900046-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765).

1 reference

https://api.crossref.org/works/10.1016%2FS2352-3026%2815%2900046-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignancies

1 reference

https://api.crossref.org/works/10.1016%2FS2352-3026%2815%2900046-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma

1 reference

https://api.crossref.org/works/10.1016%2FS2352-3026%2815%2900046-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The Bruton tyrosine kinase (BTK) inhibitor PCI-32765 synergistically increases proteasome inhibitor activity in diffuse large-B cell lymphoma (DLBCL) and mantle cell lymphoma (MCL) cells sensitive or resistant to bortezomib

1 reference

https://api.crossref.org/works/10.1016%2FS2352-3026%2815%2900046-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma

1 reference

https://api.crossref.org/works/10.1016%2FS2352-3026%2815%2900046-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS2352-3026%2815%2900046-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS2352-3026%2815%2900046-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Survey of activated FLT3 signaling in leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS2352-3026%2815%2900046-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of Bruton's tyrosine kinase as a therapeutic target in acute myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1016%2FS2352-3026%2815%2900046-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet

1 reference

https://api.crossref.org/works/10.1016%2FS2352-3026%2815%2900046-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Stem cell factor enhances the adhesion of AML cells to fibronectin and augments fibronectin-mediated anti-apoptotic and proliferative signals

1 reference

https://api.crossref.org/works/10.1016%2FS2352-3026%2815%2900046-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS2352-3026%2815%2900046-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Stem cell factor programs the mast cell activation phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS2352-3026%2815%2900046-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Btk is required for an efficient response to erythropoietin and for SCF-controlled protection against TRAIL in erythroid progenitors.

1 reference

https://api.crossref.org/works/10.1016%2FS2352-3026%2815%2900046-0

7 January 2021

based on heuristic

inferred from DOI database lookup

HO-1 underlies resistance of AML cells to TNF-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS2352-3026%2815%2900046-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Age and acute myeloid leukemia: real world data on decision to treat and outcomes from the Swedish Acute Leukemia Registry

1 reference

https://api.crossref.org/works/10.1016%2FS2352-3026%2815%2900046-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The Bruton's tyrosine kinase gene is expressed throughout B cell differentiation, from early precursor B cell stages preceding immunoglobulin gene rearrangement up to mature B cell stages

1 reference

https://api.crossref.org/works/10.1016%2FS2352-3026%2815%2900046-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Neutrophil development and function critically depend on Bruton tyrosine kinase in a mouse model of X-linked agammaglobulinemia.

1 reference

https://api.crossref.org/works/10.1016%2FS2352-3026%2815%2900046-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of stem cell factor and granulocyte colony-stimulating factor in remodeling during liver regeneration

1 reference

https://api.crossref.org/works/10.1016%2FS2352-3026%2815%2900046-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Stem cell factor increases the expression of FLIP that inhibits IFNgamma -induced apoptosis in human erythroid progenitor cells

1 reference

https://api.crossref.org/works/10.1016%2FS2352-3026%2815%2900046-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Balanced interactions between Lyn, the p85alpha regulatory subunit of class I(A) phosphatidylinositol-3-kinase, and SHIP are essential for mast cell growth and maturation

1 reference

https://api.crossref.org/works/10.1016%2FS2352-3026%2815%2900046-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The D816V mutation of c-Kit circumvents a requirement for Src family kinases in c-Kit signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS2352-3026%2815%2900046-0

7 January 2021

based on heuristic

inferred from DOI database lookup

KIT (CD117): a review on expression in normal and neoplastic tissues, and mutations and their clinicopathologic correlation

1 reference

https://api.crossref.org/works/10.1016%2FS2352-3026%2815%2900046-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS2352-3026%2815%2900046-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Selective antitumor activity of ibrutinib in EGFR-mutant non-small cell lung cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS2352-3026%2815%2900046-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS2352-3026%2815%2900046-0

7 January 2021

based on heuristic

inferred from DOI database lookup

FLT3-ITD and TLR9 use Bruton tyrosine kinase to activate distinct transcriptional programs mediating AML cell survival and proliferation.

1 reference

https://api.crossref.org/works/10.1016%2FS2352-3026%2815%2900046-0

7 January 2021

based on heuristic

inferred from DOI database lookup

A critical role for Lyn in acute myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1016%2FS2352-3026%2815%2900046-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Proteomic and genetic approaches identify Syk as an AML target

1 reference

https://api.crossref.org/works/10.1016%2FS2352-3026%2815%2900046-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S2352-3026(15)00046-0

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26688095%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

release_vau2m6irhbgn5b3rqcgspsrfai

1 reference

https://api.fatcat.wiki/v0/release/vau2m6irhbgn5b3rqcgspsrfai

24 November 2022

based on heuristic

mapped directly with Wikidata item

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26688095%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

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