(Q34055661)

30 July 2017

1 reference

title

Location, location, location: compartmentalization of early events in leukotriene biosynthesis. (English)

1 reference

30 July 2017

Marcia E Newcomer

1

1 reference

30 July 2017

Nathaniel C Gilbert

series ordinal

2

1 reference

30 July 2017

language of work or name

English

0 references

publication date

27 May 2010

1 reference

Journal of Biological Chemistry

30 July 2017

published in

1 reference

30 July 2017

volume

285

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30 July 2017

issue

33

1 reference

30 July 2017

page(s)

25109-25114

1 reference

The 1.85 Å Structure of an 8 R -Lipoxygenase Suggests a General Model for Lipoxygenase Product Specificity

30 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919072

Transcellular biosynthesis of cysteinyl leukotrienes in vivo during mouse peritoneal inflammation

28 July 2018

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Distinct parts of leukotriene C(4) synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919072

Crystal structure of the cold-active aminopeptidase from Colwellia psychrerythraea, a close structural homologue of the human bifunctional leukotriene A4 hydrolase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919072

What's all the FLAP about?: 5-lipoxygenase-activating protein inhibitors for inflammatory diseases

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919072

Conformational flexibility in mammalian 15S-lipoxygenase: Reinterpretation of the crystallographic data

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919072

Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919072

Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919072

Control of oxygenation in lipoxygenase and cyclooxygenase catalysis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919072

Crystal structures of vegetative soybean lipoxygenase VLX-B and VLX-D, and comparisons with seed isoforms LOX-1 and LOX-3

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919072

Nuclear localization of leukotriene A4 hydrolase in type II alveolar epithelial cells in normal and fibrotic lung

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919072

Membrane fluidity is a key modulator of membrane binding, insertion, and activity of 5-lipoxygenase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919072

The membrane organization of leukotriene synthesis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919072

Crystal structures of leukotriene A4 hydrolase in complex with captopril and two competitive tight-binding inhibitors

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919072

Structural and functional criteria reveal a new nuclear import sequence on the 5-lipoxygenase protein

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919072

Membrane localization and topology of leukotriene C4 synthase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919072

The N-terminal domain of the reticulocyte-type 15-lipoxygenase is not essential for enzymatic activity but contains determinants for membrane binding

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919072

Molecular basis of the specific subcellular localization of the C2-like domain of 5-lipoxygenase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919072

Three-dimensional structure of a purple lipoxygenase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919072

Co-localization of leukotriene a4 hydrolase with 5-lipoxygenase in nuclei of alveolar macrophages and rat basophilic leukemia cells but not neutrophils

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919072

Crystal structure of human leukotriene A(4) hydrolase, a bifunctional enzyme in inflammation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919072

The N-terminal "beta-barrel" domain of 5-lipoxygenase is essential for nuclear membrane translocation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919072

Structural basis for lipoxygenase specificity. Conversion of the human leukocyte 5-lipoxygenase to a 15-lipoxygenating enzyme species by site-directed mutagenesis.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919072

Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG). A widespread protein superfamily

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919072

Characterisation of the calcium-binding C-terminal domain of Clostridium perfringens alpha-toxin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919072

Lipoxygenases: occurrence, functions, catalysis, and acquisition of substrate

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919072

Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919072

The diversity of the lipoxygenase family. Many sequence data but little information on biological significance

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919072

Common structural features of MAPEG -- a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919072

Determinants of 5-lipoxygenase nuclear localization using green fluorescent protein/5-lipoxygenase fusion proteins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919072

Structure of the key toxin in gas gangrene

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919072

Calcium-dependent membrane penetration is a hallmark of the C2 domain of cytosolic phospholipase A2 whereas the C2A domain of synaptotagmin binds membranes electrostatically.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919072

The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919072

Crystal structure of soybean lipoxygenase L-1 at 1.4 A resolution

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919072

The three-dimensional structure of an arachidonic acid 15-lipoxygenase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919072

Regulation of 5-lipoxygenase and 5-lipoxygenase-activating protein expression in HL-60 cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919072

Insights from the X-ray crystal structure of coral 8R-lipoxygenase: calcium activation via a C2-like domain and a structural basis of product chirality

28 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.125880

Direct interaction of a Ca2+-binding loop of synaptotagmin with lipid bilayers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.125880

Kinetic Studies of Oxygen Reactivity in Soybean Lipoxygenase-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.125880

Steric control of oxygenation regiochemistry in soybean lipoxygenase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.125880

Tryptic digestion of soybean lipoxygenase-1 generates a 60 kDa fragment with improved activity and membrane binding ability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.125880

Fatty acid binding proteins stabilize leukotriene A4: competition with arachidonic acid but not other lipoxygenase products

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.125880

Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.125880

Catalysis within the lipid bilayer-structure and mechanism of the MAPEG family of integral membrane proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.125880

Kinetic mechanism of glutathione conjugation to leukotriene A4 by leukotriene C4 synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.125880

Reversible compartmentalization of de novo purine biosynthetic complexes in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.125880

Identification of two novel nuclear import sequences on the 5-lipoxygenase protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.125880

Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.125880

The nuclear membrane organization of leukotriene synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.125880

Enzymes without borders: mobilizing substrates, delivering products

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.125880

Nuclear localization of 5-lipoxygenase as a determinant of leukotriene B4synthetic capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.125880

Phospholipid bilayers enhance the stability of leukotriene A4 and epoxytetraenes: stabilization of eicosanoids by liposomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.125880

Mice lacking the multidrug resistance protein 1 are resistant to Streptococcus pneumoniae-induced pneumonia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.125880

Stabilization of leukotriene A4 by epithelial fatty acid-binding protein in the rat basophilic leukemia cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.125880

Mapping the phospholipid-binding surface and translocation determinants of the C2 domain from cytosolic phospholipase A2

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919072

Proton release during the pre-steady-state oxidation of aldehydes by aldehyde dehydrogenase. Evidence for a rate-limiting conformational change

28 October 2018

1 reference

12 December 2020

Reversible membrane association of neutrophil 5-lipoxygenase is accompanied by retention of activity and a change in substrate specificity

1 reference

12 December 2020

Increases in 5-lipoxygenase activating protein expression account for enhanced capacity for 5-lipoxygenase metabolism that accompanies differentiation of peripheral blood monocytes into alveolar macrophages

1 reference

12 December 2020

Human 5-lipoxygenase associates with phosphatidylcholine liposomes and modulates LTA4 synthetase activity

1 reference

12 December 2020

The N-terminal domain of 5-lipoxygenase binds calcium and mediates calcium stimulation of enzyme activity

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.R110.125880

1 reference

30 July 2017

1 reference

30 July 2017

1 reference