(Q34082587)

English

Dose- and route-dependent teratogenicity, toxicity, and pharmacokinetic profiles of the hedgehog signaling antagonist cyclopamine in the mouse.

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scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18411234%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

Dose- and route-dependent teratogenicity, toxicity, and pharmacokinetic profiles of the hedgehog signaling antagonist cyclopamine in the mouse (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18411234%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

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pharmacokinetics

1 reference

based on heuristic

inferred from title

Robert J. Lipinski

1

1 reference

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5 January 2020

6

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5 January 2020

author name string

Paul R Hutson

2

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5 January 2020

Paul W Hannam

3

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5 January 2020

Robert J Nydza

4

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5 January 2020

Ida M Washington

5

1 reference

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5 January 2020

Gary G Girdaukas

7

1 reference

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5 January 2020

Richard E Peterson

8

1 reference

Europe PubMed Central

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5 January 2020

Wade Bushman

9

1 reference

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5 January 2020

publication date

14 April 2008

1 reference

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5 January 2020

Toxicological Sciences

1 reference

Europe PubMed Central

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5 January 2020

104

1 reference

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5 January 2020

1

1 reference

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5 January 2020

189-197

1 reference

Europe PubMed Central

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5 January 2020

Mouse genetic models of cleft lip with or without cleft palate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927868

5 July 2018

Identification and characterization of several dietary alkaloids as weak inhibitors of hedgehog signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927868

5 July 2018

Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927868

5 July 2018

Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927868

5 July 2018

Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927868

5 July 2018

Sonic hedgehog pathway inhibition alters epididymal function as assessed by the development of sperm motility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927868

5 July 2018

In vivo inhibition of endogenous brain tumors through systemic interference of Hedgehog signaling in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927868

5 July 2018

Sonic hedgehog controls stem cell behavior in the postnatal and adult brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927868

5 July 2018

Hedgehog signalling in prostate regeneration, neoplasia and metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927868

5 July 2018

Temporal perturbations in sonic hedgehog signaling elicit the spectrum of holoprosencephaly phenotypes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927868

5 July 2018

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927868

5 July 2018

Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927868

5 July 2018

Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927868

5 July 2018

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927868

5 July 2018

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927868

5 July 2018

Patched acts catalytically to suppress the activity of Smoothened

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927868

5 July 2018

Gene/environment causes of cleft lip and/or palate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927868

5 July 2018

Teratogenesis of holoprosencephaly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927868

5 July 2018

Hedgehog signaling in animal development: paradigms and principles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927868

5 July 2018

Sonic hedgehog regulates gastric gland morphogenesis in man and mouse.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927868

5 July 2018

The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927868

5 July 2018

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927868

5 July 2018

Expression of Veratrum alkaloid teratogenicity in the mouse.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927868

5 July 2018

Recent advances in primary palate and midface morphogenesis research

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927868

5 July 2018

Teratogenic Effects of Cyclopamine and Jervine in Rats, Mice and Hamsters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927868

5 July 2018

Newborn and adult face shapes related to mouse cleft lip predisposition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927868

5 July 2018

Medulloblastoma growth inhibition by hedgehog pathway blockade

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFN076

21 January 2018

Sequential developmental changes in holoprosencephalic mouse embryos exposed to ethanol during the gastrulation period.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFN076

21 January 2018

Molecular interactions coordinating the development of the forebrain and face.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFN076

21 January 2018

Developmental alterations associated with spontaneous cleft lip and palate in CL/Fr mice.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFN076

21 January 2018

Craniofacial anomalies of the cultured mouse embryo induced by inhibition of sonic hedgehog signaling: an animal model of holoprosencephaly

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFN076

21 January 2018

Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927868

28 October 2018

Teratogenic compounds ofVeratrum californicum (Durand). X. Cyclopia in rabbits produced by cyclopamine

1 reference

https://pubmed.ncbi.nlm.nih.gov/18411234

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of dam strain on the craniofacial morphogenesis of CL/Fr mouse fetuses

1 reference

https://pubmed.ncbi.nlm.nih.gov/18411234

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/TOXSCI/KFN076

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18411234%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18411234%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18411234%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

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