(Q34093709)

English

Endogenous Tetrapyrroles Influence Leukocyte Responses to Lipopolysaccharide in Human Blood: Pre-Clinical Evidence Demonstrating the Anti-Inflammatory Potential of Biliverdin.

scientific article

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scholarly article

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Europe PubMed Central

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15 February 2020

Endogenous Tetrapyrroles Influence Leukocyte Responses to Lipopolysaccharide in Human Blood: Pre-Clinical Evidence Demonstrating the Anti-Inflammatory Potential of Biliverdin (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25177524%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

lipopolysaccharide

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1

1 reference

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15 February 2020

Karl-Heinz Wagner

7

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15 February 2020

author name string

Jens Tampe

2

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15 February 2020

Cecilia Shing

3

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15 February 2020

Bhavisha Bakrania

4

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15 February 2020

James Winearls

5

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15 February 2020

John Fraser

6

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15 February 2020

Andrew C Bulmer

8

1 reference

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15 February 2020

publication date

1 May 2014

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15 February 2020

Journal of Clinical & Cellular Immunology

1 reference

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15 February 2020

5

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15 February 2020

218

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15 February 2020

1000218

1 reference

Europe PubMed Central

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15 February 2020

Biliverdin modulates the expression of C5aR in response to endotoxin in part via mTOR signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

5 July 2018

The molecular basis for the immunomodulatory activities of unconjugated bilirubin

1 reference

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5 July 2018

Role of the aryl hydrocarbon receptor (AhR) in lung inflammation

1 reference

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5 July 2018

Biliverdin protects against liver ischemia reperfusion injury in swine.

1 reference

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5 July 2018

Effects of biliverdin administration on acute lung injury induced by hemorrhagic shock and resuscitation in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

5 July 2018

Genomic responses in mouse models poorly mimic human inflammatory diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

5 July 2018

Human recombinant protein C for severe sepsis and septic shock in adult and paediatric patients

1 reference

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5 July 2018

New approaches to the study of sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

5 July 2018

Bilirubin and beyond: a review of lipid status in Gilbert's syndrome and its relevance to cardiovascular disease protection.

1 reference

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5 July 2018

Effects of bilirubin on neutrophil responses in newborn infants.

1 reference

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5 July 2018

Current trends in inflammatory and immunomodulatory mediators in sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

5 July 2018

Inflammation, leukocytes and menstruation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

5 July 2018

Reduced circulating oxidized LDL is associated with hypocholesterolemia and enhanced thiol status in Gilbert syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

5 July 2018

Biliverdin inhibits Toll-like receptor-4 (TLR4) expression through nitric oxide-dependent nuclear translocation of biliverdin reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

5 July 2018

TLR activation enhances C5a-induced pro-inflammatory responses by negatively modulating the second C5a receptor, C5L2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

5 July 2018

Recent advances on the role of cytokines in atherosclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

5 July 2018

Bile pigment pharmacokinetics and absorption in the rat: therapeutic potential for enteral administration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

5 July 2018

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

5 July 2018

XOMA 052, a potent, high-affinity monoclonal antibody for the treatment of IL-1β-mediated diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

5 July 2018

Contributions of the Ah receptor to bilirubin homeostasis and its antioxidative and atheroprotective functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

5 July 2018

Cell surface biliverdin reductase mediates biliverdin-induced anti-inflammatory effects via phosphatidylinositol 3-kinase and Akt.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

5 July 2018

The role of the anaphylatoxins in health and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

5 July 2018

Arylhydrocarbon receptor activation in NCI-H441 cells and C57BL/6 mice: possible mechanisms for lung dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

5 July 2018

Molecular biology of inflammation and sepsis: a primer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

5 July 2018

CO and bilirubin inhibit doxorubicin-induced cardiac cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

5 July 2018

Bilirubin in clinical practice: a review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

5 July 2018

Role of Toll-like receptors in the development of sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

5 July 2018

Biliverdin inhibits activation of NF-kappaB: reversal of inhibition by human biliverdin reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

5 July 2018

Single bolus injection of bilirubin improves the clinical outcome in a mouse model of endotoxemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

5 July 2018

Association between the UGT1A1*28 allele, bilirubin levels, and coronary heart disease in the Framingham Heart Study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

5 July 2018

Differential regulation of monocyte/macrophage cytokine production by pressure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

5 July 2018

Bilirubin decreases nos2 expression via inhibition of NAD(P)H oxidase: implications for protection against endotoxic shock in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

5 July 2018

Hematologic changes in sepsis and their therapeutic implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

5 July 2018

The use of real time rtPCR to quantify inflammatory mediator expression in leukocytes from patients with severe sepsis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

5 July 2018

Bilirubin inhibits iNOS expression and NO production in response to endotoxin in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

5 July 2018

Seasonal variation in whole blood cytokine production after LPS stimulation in normal individuals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

5 July 2018

Inverse Relationship Between Serum Bilirubin and Atherosclerosis in Men: A Meta-Analysis of Published Studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

5 July 2018

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

5 July 2018

Neonatal hyperbilirubinemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

5 July 2018

A semi-quantitative reverse transcriptase polymerase chain reaction method for measurement of MRNA for TNF-alpha and IL-1 beta in whole blood cultures: its application in typhoid fever and exentric exercise

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

5 July 2018

INTERSEPT: an international, multicenter, placebo-controlled trial of monoclonal antibody to human tumor necrosis factor-alpha in patients with sepsis. International Sepsis Trial Study Group.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

5 July 2018

Time course-dependent changes in the transcriptome of human skeletal muscle during recovery from endurance exercise: from inflammation to adaptive remodeling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

28 October 2018

Inflammatory responses induced by lipopolysaccharide are amplified in primary human monocytes but suppressed in macrophages by complement protein C5a.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

28 October 2018

Recipient hyperbilirubinaemia protects cardiac graft in rat heterotopic heart transplantation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

28 October 2018

Haem catabolism: a novel modulator of inflammation in Gilbert's syndrome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

28 October 2018

Exogenous biliverdin improves the function of lung grafts from brain dead donors in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

28 October 2018

Lipopolysaccharide-stimulated whole blood cytokine production does not predict the inflammatory response in human endotoxemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

28 October 2018

Improved resistance to serum oxidation in Gilbert's syndrome: a mechanism for cardiovascular protection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

28 October 2018

Biliverdin protects against polymicrobial sepsis by modulating inflammatory mediators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

28 October 2018

Inflammatory signalling pathways involved in astroglial activation by unconjugated bilirubin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

28 October 2018

Biliverdin administration protects against endotoxin-induced acute lung injury in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

28 October 2018

Protection against ischemia/reperfusion injury in cardiac and renal transplantation with carbon monoxide, biliverdin and both

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

28 October 2018

Biliverdin therapy protects rat livers from ischemia and reperfusion injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

28 October 2018

Biliverdin protects the functional integrity of a transplanted syngeneic small bowel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

28 October 2018

Biliverdin, a natural product of heme catabolism, induces tolerance to cardiac allografts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145741

28 October 2018

Stabilization of mRNA expression in whole blood samples.

1 reference

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28 October 2018

Apoptosis in murine hepatoma hepa 1c1c7 wild-type, C12, and C4 cells mediated by bilirubin

1 reference

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28 October 2018

Bilirubin produces apoptosis in cultured bovine brain endothelial cells.

1 reference

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28 October 2018

Cytokine modulation in experimental endotoxemia: characterization of an ex vivo whole blood model

1 reference

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28 October 2018

Bilirubin Can Induce Tolerance to Islet Allografts

1 reference

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28 October 2018

Kinetics of TNF, IL-6, and IL-8 gene expression in LPS-stimulated human whole blood

1 reference

https://pubmed.ncbi.nlm.nih.gov/25177524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-inflammatory therapies to treat sepsis and septic shock: a reassessment

1 reference

https://pubmed.ncbi.nlm.nih.gov/25177524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neonatal hyperbilirubinemia--what are the risks?

1 reference

https://pubmed.ncbi.nlm.nih.gov/25177524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/25177524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of an anti-tumor necrosis factor monoclonal antibody on cytokine levels in patients with sepsis. The CB0006 Sepsis Syndrome Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/25177524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

INTERLEUKIN 8 PRODUCTION IN WHOLE BLOOD ASSAYS: IS INTERLEUKIN 10 RESPONSIBLE FOR THE DOWNREGULATION OBSERVED IN SEPSIS?

1 reference

https://pubmed.ncbi.nlm.nih.gov/25177524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic factors influencing atazanavir plasma concentrations and the risk of severe hyperbilirubinemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/25177524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.4172/2155-9899.1000218

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25177524%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25177524%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25177524%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

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