(Q34106569)

31 July 2017

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title

The molecular basis of T helper 1 and T helper 2 cell differentiation (English)

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31 July 2017

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1

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31 July 2017

Arai N

2

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31 July 2017

1 December 2000

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31 July 2017

Trends in Cell Biology

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31 July 2017

10

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31 July 2017

542-550

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31 July 2017

12

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The expanding universe of T-cell subsets: Th1, Th2 and more.

31 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Regulation of immunity to parasites by T cells and T cell-derived cytokines

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Functional diversity of helper T lymphocytes

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Cytokines induce the development of functionally heterogeneous T helper cell subsets

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Cytokine regulation of T-cell function: potential for therapeutic intervention

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

CD4+ T-cell subsets in autoimmunity

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

The importance of Th2 cytokines in protective immunity to nematodes.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Lymphokine production by human T cells in disease states

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Lymphocyte responses and cytokines

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Limited role of CD28-mediated signals in T helper subset differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

CD40 AND CD154 IN CELL-MEDIATED IMMUNITY

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Intercellular adhesion molecule-1 inhibits interleukin 4 production by naive T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

T-cell subsets: transcriptional control in the Th1/Th2 decision

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Genes that regulate interleukin-4 expression in T cells

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Th2-specific DNase I-hypersensitive sites in the murine IL-13 and IL-4 intergenic region.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Signaling and transcription in T helper development

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Stability of Th1 and Th2 populations

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Developmental commitment to the Th2 lineage by extinction of IL-12 signaling.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Reversibility of T helper 1 and 2 populations is lost after long-term stimulation

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Uptake of microparticle-adsorbed protein antigen by bone marrow-derived dendritic cells results in up-regulation of interleukin-1 alpha and interleukin-12 p40/p35 and triggers prolonged, efficient antigen presentation.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

CD8alpha+ and CD8alpha- subclasses of dendritic cells direct the development of distinct T helper cells in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Distinct dendritic cell subsets differentially regulate the class of immune response in vivo

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Reciprocal control of T helper cell and dendritic cell differentiation

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

The Ets transcription factor ERM is Th1-specific and induced by IL-12 through a Stat4-dependent pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Selective expression of an interleukin-12 receptor component by human T helper 1 cells

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

T helper type 2 cell differentiation occurs in the presence of interleukin 12 receptor beta2 chain expression and signaling

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Cutting edge: ectopic expression of the IL-12 receptor-beta 2 in developing and committed Th2 cells does not affect the production of IL-4 or induce the production of IFN-gamma.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Cloning of a new cytokine that induces IFN-gamma production by T cells

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Regulation of interferon-gamma production by IL-12 and IL-18.

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NFkappaB.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Purification and characterization of the human interleukin-18 receptor

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Selective expression and functions of interleukin 18 receptor on T helper (Th) type 1 but not Th2 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

IL-18 receptors, their role in ligand binding and function: anti-IL-1RAcPL antibody, a potent antagonist of IL-18.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Defective NK cell activity and Th1 response in IL-18-deficient mice

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Interferon regulatory factor-1 is required for a T helper 1 immune response in vivo

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Multistage regulation of Th1-type immune responses by the transcription factor IRF-1

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Interleukin-12 induces expression of interferon regulatory factor-1 via signal transducer and activator of transcription-4 in human T helper type 1 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Defective T Cell Differentiation in the Absence of Jnk1

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Regulation of expression of the human interferon gamma gene

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https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Two essential regulatory elements in the human interferon gamma promoter confer activation specific expression in T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

The Proximal Regulatory Element of the Interferon-γ Promoter Mediates Selective Expression in T Cells

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Differential transcription directed by discrete gamma interferon promoter elements in naive and memory (effector) CD4 T cells and CD8 T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

GATA-3 significantly downregulates IFN-gamma production from developing Th1 cells in addition to inducing IL-4 and IL-5 levels

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Interaction of NF-kappaB and NFAT with the interferon-gamma promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

The nuclear factor YY1 suppresses the human gamma interferon promoter through two mechanisms: inhibition of AP1 binding and activation of a silencer element.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

The roles of nuclear factor of activated T cells and ying-yang 1 in activation-induced expression of the interferon-gamma promoter in T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Identification of a calcium-inducible, cyclosporine sensitive element in the IFN-gamma promoter that is a potential NFAT binding site

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

A novel transcription factor, T-bet, directs Th1 lineage commitment

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

A "knockdown" mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

An interleukin-4-induced transcription factor: IL-4 Stat

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Growth and gene expression are predominantly controlled by distinct regions of the human IL-4 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Essential role of Stat6 in IL-4 signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Generation and analysis of interleukin-4 deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Disruption of the murine IL-4 gene blocks Th2 cytokine responses.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

An enhanced immune response in mice lacking the transcription factor NFAT1.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Down-regulation of IL-4 gene transcription and control of Th2 cell differentiation by a mechanism involving NFAT1

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Activation of the interleukin-5 promoter by cAMP in murine EL-4 cells requires the GATA-3 and CLE0 elements

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Computational and biological analysis of 680 kb of DNA sequence from the human 5q31 cytokine gene cluster region

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Identification of a Coordinate Regulator of Interleukins 4, 13, and 5 by Cross-Species Sequence Comparisons

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

The granulocyte-macrophage colony-stimulating factor/interleukin 3 locus is regulated by an inducible cyclosporin A-sensitive enhancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Regulation of interferon-gamma gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Cell division regulates the T cell cytokine repertoire, revealing a mechanism underlying immune class regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Helper T cell differentiation is controlled by the cell cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Instruction for cytokine expression in T helper lymphocytes in relation to proliferation and cell cycle progression

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

Independent and epigenetic regulation of the interleukin-4 alleles in CD4+ T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0962-8924%2800%2901856-0

7 January 2021

10.1016/S0962-8924(00)01856-0

Identifiers

DOI

1 reference

31 July 2017

1 reference

PubMed ID

11121747