(Q34114554)

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Chronic exposure of HIT cells to high glucose concentrations paradoxically decreases insulin gene transcription and alters binding of insulin gene regulatory protein.

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29 October 2019

Chronic exposure of HIT cells to high glucose concentrations paradoxically decreases insulin gene transcription and alters binding of insulin gene regulatory protein (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8326016%20AND%20SRC:MED&resulttype=core&format=json

29 October 2019

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J. Bruce Redmon

2

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29 October 2019

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L K Olson

1

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29 October 2019

H C Towle

3

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29 October 2019

R P Robertson

4

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29 October 2019

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1 July 1993

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29 October 2019

Journal of Clinical Investigation

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29 October 2019

92

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29 October 2019

514-519

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29 October 2019

1

1 reference

Europe PubMed Central

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29 October 2019

The defective glucose sensitivity of the B cell in non insulin dependent diabetes. Improvement after twenty hours of normoglycaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293640

5 July 2018

Improvement of insulin secretion but not insulin resistance after short term control of plasma glucose in obese type II diabetics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293640

5 July 2018

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293640

5 July 2018

Insulin synthesis in a clonal cell line of simian virus 40-transformed hamster pancreatic beta cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293640

5 July 2018

Hyperglycaemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: implications for the management of diabetes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293640

5 July 2018

Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293640

5 July 2018

A beta-cell-specific protein binds to the two major regulatory sequences of the insulin gene enhancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293640

5 July 2018

Minimal chronic hyperglycemia is a critical determinant of impaired insulin secretion after an incomplete pancreatectomy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293640

5 July 2018

Severe diabetes induced in subtotally depancreatized dogs by sustained hyperglycemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293640

5 July 2018

Systematic binding analysis of the insulin gene transcription control region: insulin and immunoglobulin enhancers utilize similar transactivators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293640

5 July 2018

Glucose regulates preproinsulin messenger RNA levels in a clonal cell line of simian virus 40-transformed B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293640

5 July 2018

Insulin secretory responses of a clonal cell line of simian virus 40-transformed B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293640

5 July 2018

Sequence-specific interactions of nuclear factors with the insulin gene enhancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293640

5 July 2018

Receptor-mediated adenylate cyclase-coupled mechanism for PGE2 inhibition of insulin secretion in HIT cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293640

5 July 2018

A tissue-specific nuclear factor binds to multiple sites in the human insulin-gene enhancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293640

5 July 2018

Type II diabetes, glucose "non-sense," and islet desensitization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293640

5 July 2018

Individual protein-binding domains of the insulin gene enhancer positively activate beta-cell-specific transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293640

5 July 2018

Perifusion of a clonal cell line of Simian virus 40-transformed beta cells. Insulin secretory dynamics in response to glucose, 3-isobutyl-1-methylxanthine, and potassium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293640

5 July 2018

Insulin secretion and cAMP metabolism in HIT cells. Reciprocal and serial passage-dependent relationships

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293640

5 July 2018

Pan: a transcriptional regulator that binds chymotrypsin, insulin, and AP-4 enhancer motifs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293640

5 July 2018

Insulin enhancer binding protein has helix-loop-helix structure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293640

5 July 2018

Positive and negative regulation of the human insulin gene by multiple trans-acting factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293640

5 July 2018

Regulation of insulin gene expression by glucose and calcium in transfected primary islet cultures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293640

5 July 2018

Glucose induces insulin gene transcription in a murine pancreatic beta-cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293640

5 July 2018

Two Related Helix-Loop-Helix Proteins Participate in Separate Cell-Specific Complexes That Bind the Insulin Enhancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293640

5 July 2018

Preservation of insulin mRNA levels and insulin secretion in HIT cells by avoidance of chronic exposure to high glucose concentrations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293640

5 July 2018

Definition of the carbohydrate response element of the rat S14 gene. Evidence for a common factor required for carbohydrate regulation of hepatic genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293640

5 July 2018

The insulin and islet amyloid polypeptide genes contain similar cell-specific promoter elements that bind identical beta-cell nuclear complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293640

5 July 2018

Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the beta-cell function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293640

5 July 2018

Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293640

5 July 2018

Beta-cell function improved by supplementing basal insulin secretion in mild diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293640

5 July 2018

Effect of control of blood glucose on plasma insulin responses to various stimuli in secondary failures to oral hypoglycemic agents and in newly diagnosed, maturity onset, ketosis-resistant diabetics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293640

5 July 2018

Increase in insulin response after treatment of overt maturity-onset diabetes is independent of the mode of treatment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=293640

28 October 2018

Direct effect of glucose on the preproinsulin mRNA level in isolated pancreatic islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/8326016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of glucose on proinsulin messenger RNA in rats in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/8326016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of insulin gene expression in pancreatic beta-cells and in an insulin-producing cell line, RIN-5F cells. II. Regulation of insulin mRNA stability

1 reference

https://pubmed.ncbi.nlm.nih.gov/8326016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin release from a cloned hamster B-cell line (HIT-T15). The effects of glucose, amino acids, sulphonylureas and colchicine

1 reference

https://pubmed.ncbi.nlm.nih.gov/8326016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fuel-stimulated insulin secretion by clonal hamster beta-cell line HIT T-15

1 reference

https://pubmed.ncbi.nlm.nih.gov/8326016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation and specificity of glucose-stimulated insulin gene expression in human islets of Langerhans

1 reference

https://pubmed.ncbi.nlm.nih.gov/8326016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequences within the 5'-flanking region of the S14 gene confer responsiveness to glucose in primary hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8326016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI116596

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8326016%20AND%20SRC:MED&resulttype=core&format=json

29 October 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8326016%20AND%20SRC:MED&resulttype=core&format=json

29 October 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8326016%20AND%20SRC:MED&resulttype=core&format=json

29 October 2019

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