(Q34118849)

24903552

31 July 2017

title

Understanding melatonin receptor pharmacology: latest insights from mouse models, and their relevance to human disease (English)

1 reference

31 July 2017

0 references

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24903552%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

author name string

Sharon Owino

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24903552%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Jean-Luc Guillaume

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24903552%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Ralf Jockers

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24903552%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

language of work or name

English

0 references

publication date

5 June 2014

1 reference

31 July 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24903552%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

volume

36

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24903552%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24903552%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

page(s)

778-787

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24903552%20AND%20SRC:MED&resulttype=core&format=json

MT1 and MT2 melatonin receptors: ligands, models, oligomers, and therapeutic potential.

7 June 2020

cites work

1 reference

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Melatonin MT₁ and MT₂ receptors display different molecular pharmacologies only in the G-protein coupled state.

5 July 2018

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Heteromeric MT1/MT2 melatonin receptors modulate photoreceptor function

5 July 2018

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Minireview: Toward the establishment of a link between melatonin and glucose homeostasis: association of melatonin MT2 receptor variants with type 2 diabetes

5 July 2018

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New radioligands for describing the molecular pharmacology of MT1 and MT2 melatonin receptors

5 July 2018

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Sequencing ASMT identifies rare mutations in Chinese Han patients with autism

5 July 2018

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Circadian gating of epithelial-to-mesenchymal transition in breast cancer cells via melatonin-regulation of GSK3β.

5 July 2018

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Melatonin: an underappreciated player in retinal physiology and pathophysiology

5 July 2018

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Evidence of the receptor-mediated influence of melatonin on pancreatic glucagon secretion via the Gαq protein-coupled and PI3K signaling pathways

5 July 2018

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Central and peripheral circadian clocks in mammals

5 July 2018

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Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes

5 July 2018

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Molecular pharmacology of the mouse melatonin receptors MT₁ and MT₂.

5 July 2018

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Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligand

5 July 2018

1 reference

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Localization of melatonin receptor 1 in mouse retina and its role in the circadian regulation of the electroretinogram and dopamine levels

5 July 2018

1 reference

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Removal of melatonin receptor type 1 increases intraocular pressure and retinal ganglion cells death in the mouse.

5 July 2018

1 reference

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Molecular organization and dynamics of the melatonin MT₁ receptor/RGS20/G(i) protein complex reveal asymmetry of receptor dimers for RGS and G(i) coupling

5 July 2018

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International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors

5 July 2018

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Genetic variation of melatonin productivity in laboratory mice under domestication

5 July 2018

1 reference

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Removal of melatonin receptor type 1 induces insulin resistance in the mouse.

5 July 2018

1 reference

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Melatonin MT1 and MT2 receptor expression in Parkinson's disease

5 July 2018

1 reference

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The end of a myth: cloning and characterization of the ovine melatonin MT(2) receptor.

5 July 2018

1 reference

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Urinary 6-sulfatoxymelatonin level in age-related macular degeneration patients.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Melatonin modulates visual function and cell viability in the mouse retina via the MT1 melatonin receptor.

5 July 2018

1 reference

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Melatonin: signaling mechanisms of a pleiotropic agent

5 July 2018

1 reference

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Sleep-promoting action of IIK7, a selective MT2 melatonin receptor agonist in the rat

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk

5 July 2018

1 reference

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Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

5 July 2018

1 reference

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Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new?

5 July 2018

1 reference

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Molecular cloning and pharmacological characterization of rat melatonin MT1 and MT2 receptors

5 July 2018

1 reference

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Involvement of the cGMP pathway in mediating the insulin-inhibitory effect of melatonin in pancreatic beta-cells

5 July 2018

1 reference

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Circadian rhythms in the eye: the physiological significance of melatonin receptors in ocular tissues

5 July 2018

1 reference

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Abnormal melatonin synthesis in autism spectrum disorders

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

The MT2 melatonin receptor subtype is present in human retina and decreases in Alzheimer's disease

5 July 2018

1 reference

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Melatonin stimulates glucose transport via insulin receptor substrate-1/phosphatidylinositol 3-kinase pathway in C2C12 murine skeletal muscle cells

5 July 2018

1 reference

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Are G protein-coupled receptor heterodimers of physiological relevance?--Focus on melatonin receptors

5 July 2018

1 reference

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Preferential formation of MT1/MT2 melatonin receptor heterodimers with distinct ligand interaction properties compared with MT2 homodimers

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Targeted disruption of the mouse Mel(1b) melatonin receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Receptor (MT(1)) mediated influence of melatonin on cAMP concentration and insulin secretion of rat insulinoma cells INS-1.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Identification and functional characterization of melatonin Mel 1a receptors in pancreatic beta cells: potential role in incretin-mediated cell function by sensitization of cAMP signaling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Distribution of melatonin MT1 receptor immunoreactivity in human retina

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Rhythmic gene expression in pituitary depends on heterologous sensitization by the neurohormone melatonin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Comparative effects of melatonin, zolpidem and diazepam on sleep, body temperature, blood pressure and heart rate measured by radiotelemetry in Wistar rats

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Activation of MT(2) melatonin receptors in rat suprachiasmatic nucleus phase advances the circadian clock

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Entrainment of free-running circadian rhythms by melatonin in blind people

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Melatonin modulation of prolactin and gonadotrophin secretion. Systems ancient and modern.

5 July 2018

1 reference

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Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Tight association of the human Mel(1a)-melatonin receptor and G(i): precoupling and constitutive activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Design of subtype selective melatonin receptor agonists and antagonists

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Selective MT2 melatonin receptor antagonists block melatonin-mediated phase advances of circadian rhythms

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

The clock in the mouse retina: melatonin synthesis and photoreceptor degeneration

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Melatonin receptors: molecular biology of a new family of G protein-coupled receptors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

The melatonin rhythm-generating enzyme: molecular regulation of serotonin N-acetyltransferase in the pineal gland

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Structure, characterization, and expression of the gene encoding the mouse Mel1a melatonin receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Characterization and regulation of the human ML1A melatonin receptor stably expressed in Chinese hamster ovary cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Effects of melatonin on sleep and neurochemistry in the rat

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Genetic control of melatonin synthesis in the pineal gland of the mouse

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Effect of pinealectomy on plasma glucose, insulin and glucagon levels in the rat.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Effects of melatonin and 5-methoxytryptamine on sleep-wake patterns in the male rat.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

GTP modulates [125I]iodomelatonin binding to a picomolar-affinity site in the Syrian hamster hypothalamus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Melatonin acts through MT1/MT2 receptors to activate hypothalamic Akt and suppress hepatic gluconeogenesis in rats.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Alterations of melatonin receptors MT1 and MT2 in the hypothalamic suprachiasmatic nucleus during depression

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Sleep-wake characterization of double MT₁/MT₂ receptor knockout mice and comparison with MT₁ and MT₂ receptor knockout mice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Genetic and functional abnormalities of the melatonin biosynthesis pathway in patients with bipolar disorder

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

The endogenous melatonin (MT) signal facilitates reentrainment of the circadian system to light-induced phase advances by acting upon MT2 receptors.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Melatonin receptor 1A gene polymorphism associated with polycystic ovary syndrome.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Distribution of melatonin receptors in murine pancreatic islets.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Loss of melatonin signalling and its impact on circadian rhythms in mouse organs regulating blood glucose

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Melatonin transmits photoperiodic signals through the MT1 melatonin receptor

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

The PDZ protein mupp1 promotes Gi coupling and signaling of the Mt1 melatonin receptor

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Targeted deletions of Mel1a and Mel1b melatonin receptors affect pCREB levels in lactotroph and pars intermedia cells of mice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Decreased MT1 melatonin receptor expression in the suprachiasmatic nucleus in aging and Alzheimer's disease

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Mice, melatonin and the circadian system

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Effects of melatonin in age-related macular degeneration

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Rhythms in clock proteins in the mouse pars tuberalis depend on MT1 melatonin receptor signalling.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Effect of MT1 melatonin receptor deletion on melatonin-mediated phase shift of circadian rhythms in the C57BL/6 mouse

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

In vivo activation of insulin receptor tyrosine kinase by melatonin in the rat hypothalamus.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Molecular pharmacology of the ovine melatonin receptor: comparison with recombinant human MT1 and MT2 receptors

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

The GABA(A) receptor mediates the hypnotic activity of melatonin in rats

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Melatonin inhibits insulin secretion and decreases PKA levels without interfering with glucose metabolism in rat pancreatic islets.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Natural melatonin 'knockdown' in C57BL/6J mice: rare mechanism truncates serotonin N-acetyltransferase

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Daily variations in pineal melatonin concentrations in inbred and outbred mice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

HPLC validation of a circadian melatonin rhythm in the pineal gland of inbred mice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

The regulation of insulin action in isolated adipocytes. Role of the periodicity of food intake, time of day and melatonin.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151498

Melatonin limits transcriptional impact of phosphoCREB in the mouse SCN via the Mel1a receptor

28 October 2018

1 reference

12 December 2020

Effects of melatonin on neuronal activity in the rat suprachiasmatic nucleus in vitro

1 reference

12 December 2020

Melatonin content of the pineal gland in different mouse strains

1 reference

12 December 2020

Effects of melatonin on spontaneous electrical activity of neurons in rat suprachiasmatic nuclei: an in vitro iontophoretic study

1 reference

12 December 2020

Evidence for multiple forms of melatonin receptor-G-protein complexes by solubilization and gel electrophoresis

1 reference

12 December 2020

Melatonin and light induce phase shifts of circadian activity rhythms in the C3H/HeN mouse

1 reference

12 December 2020

Melatonin action and signal transduction in the rat suprachiasmatic circadian clock: activation of protein kinase C at dusk and dawn

1 reference

12 December 2020

Differential signaling of human Mel1a and Mel1b melatonin receptors through the cyclic guanosine 3'-5'-monophosphate pathway

1 reference

12 December 2020

Identifiers

DOI

10.1002/BIES.201400017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24903552%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24903552%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

24903552

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24903552%20AND%20SRC:MED&resulttype=core&format=json