(Q34122321)

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The ghrelin gene products and exendin-4 promote survival of human pancreatic islet endothelial cells in hyperglycaemic conditions, through phosphoinositide 3-kinase/Akt, extracellular signal-related kinase (ERK)1/2 and cAMP/protein kinase A [...]

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22231124%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

The ghrelin gene products and exendin-4 promote survival of human pancreatic islet endothelial cells in hyperglycaemic conditions, through phosphoinositide 3-kinase/Akt, extracellular signal-related kinase (ERK)1/2 and cAMP/protein kinase A (PKA) signalling pathways (English)

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20 January 2020

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Riccarda Granata

2

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20 January 2020

Giovanni Camussi

8

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20 January 2020

author name string

E Favaro

1

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20 January 2020

I Miceli

3

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20 January 2020

A Baragli

4

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20 January 2020

F Settanni

5

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20 January 2020

P Cavallo Perin

6

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20 January 2020

E Ghigo

7

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20 January 2020

M M Zanone

9

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20 January 2020

publication date

10 January 2012

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20 January 2020

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20 January 2020

55

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20 January 2020

4

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20 January 2020

1058-1070

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20 January 2020

https://scigraph.springernature.com/pub.10.1007/s00125-011-2423-y

0 references

Glucagon-like peptide 1 protects microvascular endothelial cells by inactivating the PARP-1/iNOS/NO pathway

1 reference

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5 July 2018

Unraveling the role of the ghrelin gene peptides in the endocrine pancreas.

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5 July 2018

Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296004

5 July 2018

Unacylated ghrelin rescues endothelial progenitor cell function in individuals with type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296004

5 July 2018

Reduced ghrelin in endothelial cells plays important mechanistic role in aging-related impairment of angiogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296004

5 July 2018

Effect of glucagon-like peptide-1 on beta- and alpha-cell function in isolated islet and whole pancreas transplant recipients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296004

5 July 2018

Hyperglycemia induces apoptosis of human pancreatic islet endothelial cells: effects of pravastatin on the Akt survival pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296004

5 July 2018

Beta cell mass in diabetes: a realistic therapeutic target?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296004

5 July 2018

From endothelial to beta cells: insights into pancreatic islet microendothelium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296004

5 July 2018

Normal food intake and body weight in mice lacking the G protein-coupled receptor GPR39.

1 reference

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5 July 2018

The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296004

5 July 2018

Primary and immortalised human pancreatic islet endothelial cells: phenotypic and immunological characterisation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296004

5 July 2018

Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296004

5 July 2018

Emerging role of protein kinase B/Akt signaling in pancreatic beta-cell mass and function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296004

5 July 2018

Expression of nephrin by human pancreatic islet endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296004

5 July 2018

Non-acylated ghrelin counteracts the metabolic but not the neuroendocrine response to acylated ghrelin in humans.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296004

5 July 2018

The role of vascular endothelial growth factor (VEGF) in renal pathophysiology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296004

5 July 2018

Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296004

5 July 2018

Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296004

5 July 2018

CD154/CD40-mediated expression of CD154 in endothelial cells: consequences for endothelial cell-monocyte interaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296004

5 July 2018

Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296004

5 July 2018

Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296004

5 July 2018

Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296004

5 July 2018

Endothelial cell apoptosis: biochemical characteristics and potential implications for atherosclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296004

5 July 2018

Islet blood flow in multiple low dose streptozotocin-treated wild-type and inducible nitric oxide synthase-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296004

5 July 2018

Cytoprotection of human umbilical vein endothelial cells against apoptosis and CTL-mediated lysis provided by caspase-resistant Bcl-2 without alterations in growth or activation responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296004

5 July 2018

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296004

5 July 2018

Cellular survival: a play in three Akts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296004

5 July 2018

Changes in islet capillary angioarchitecture coincide with impaired B-cell function but not with insulin resistance in male Otsuka-Long-Evans-Tokushima fatty rats: dimorphism of the diabetic phenotype at an advanced age.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296004

5 July 2018

Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for CD40-CD40 ligand signaling in atherosclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296004

5 July 2018

Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296004

5 July 2018

Vascular addressins are induced on islet vessels during insulitis in nonobese diabetic mice and are involved in lymphoid cell binding to islet endothelium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296004

5 July 2018

Primary cultures of rat islet capillary endothelial cells. Constitutive and cytokine-inducible macrophagelike nitric oxide synthases are expressed and activities regulated by glucose concentration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3296004

5 July 2018

Obestatin promotes survival of pancreatic beta-cells and human islets and induces expression of genes involved in the regulation of beta-cell mass and function.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2423-Y

21 January 2018

Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2423-Y

21 January 2018

Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2423-Y

21 January 2018

Induction of pancreatic differentiation by signals from blood vessels.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2423-Y

21 January 2018

Role of VEGF-A in vascularization of pancreatic islets

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2423-Y

21 January 2018

Pancreatic islet production of vascular endothelial growth factor--a is essential for islet vascularization, revascularization, and function.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2423-Y

21 January 2018

Endothelial cell signalling supports pancreatic beta cell function in the rat.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2423-Y

21 January 2018

Islet endothelial cells and pancreatic beta-cell proliferation: studies in vitro and during pregnancy in adult rats.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2423-Y

21 January 2018

Islet microvasculature in islet hyperplasia and failure in a model of type 2 diabetes.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2423-Y

21 January 2018

The development of new density gradient media for purifying human islets and islet-quality assessments

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2423-Y

21 January 2018

Persistent infection of human microvascular endothelial cells by coxsackie B viruses induces increased expression of adhesion molecules.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2423-Y

21 January 2018

A glucagon-like peptide-1 (GLP-1) analogue, liraglutide, upregulates nitric oxide production and exerts anti-inflammatory action in endothelial cells

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2423-Y

21 January 2018

CD40L blockade prevents autoimmune diabetes by induction of bitypic NK/DC regulatory cells

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2423-Y

21 January 2018

Exendin-4 stimulates proliferation of human coronary artery endothelial cells through eNOS-, PKA- and PI3K/Akt-dependent pathways and requires GLP-1 receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/22231124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of ghrelin and of the GH secretagogue receptor by pancreatic islet cells and related endocrine tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22231124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of vascular cell adhesion molecule 1 on human dermal microvascular endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22231124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: involvement of 3',5'-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl

1 reference

https://pubmed.ncbi.nlm.nih.gov/22231124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00125-011-2423-Y

1 reference

Europe PubMed Central

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20 January 2020

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1 reference

Europe PubMed Central

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20 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22231124%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

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