(Q34126387)

31 July 2017

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title

In vivo models of myocardial ischemia and reperfusion injury: application to drug discovery and evaluation (English)

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31 July 2017

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Black SC

1

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31 July 2017

publication date

1 March 2000

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Journal of Pharmacological and Toxicological Methods

31 July 2017

published in

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31 July 2017

volume

43

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31 July 2017

issue

2

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31 July 2017

page(s)

153-167

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Reduction in experimental infarct size by recombinant human superoxide dismutase: insights into the pathophysiology of reperfusion injury

31 July 2017

cites work

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7 January 2021

The relationship between oxygen radical generation and impairment of myocardial energy metabolism following post-ischemic reperfusion,

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7 January 2021

Myocyte death in the pathological heart

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7 January 2021

Intracoronary adenosine administration during reperfusion following 3 hours of ischemia: effects on infarct size, ventricular function, and regional myocardial blood flow

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7 January 2021

Myocyte apoptosis during acute myocardial infarction in the mouse localizes to hypoxic regions but occurs independently of p53

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7 January 2021

Regulation of the Na+/H+ exchanger isoform NHE1: role of phosphorylation

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7 January 2021

Inhibition of Platelet-Activating Factor Fails to Limit Ischemia and Reperfusion-Induced Myocardial Damage

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7 January 2021

Co-localization of the cysteine protease caspase-3 with apoptotic myocytes after in vivo myocardial ischemia and reperfusion in the rat

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7 January 2021

Methods for studying experimental myocardial ischemic and reperfusion injury

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7 January 2021

Common methodological problems and artifacts associated with studies of myocardial stunning in vivo

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7 January 2021

Actions of pinacidil at a reduced potassium concentration: a direct cardiac effect possibly involving the ATP-dependent potassium channel

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7 January 2021

Effect of superoxide dismutase on myocardial infarct size in the canine heart after 6 hours of regional ischemia and reperfusion: a demonstration of myocardial salvage

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7 January 2021

Free radicals in ischemic and reperfusion myocardial injury: is this the time for clinical trials?

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7 January 2021

Adenosine: a physiological modulator of superoxide anion generation by human neutrophils.

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7 January 2021

Models for the study of arrhythmias in myocardial ischaemia and infarction: the use of the rat.

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7 January 2021

Pathophysiology of superoxide radical as potential mediator of reperfusion injury in pig heart

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https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

The physiological activity of adenine compounds with especial reference to their action upon the mammalian heart

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https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction

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https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Unresolved issues regarding the role of apoptosis in the pathogenesis of ischemic injury and heart failure

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https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

GUARD During Ischemia Against Necrosis (GUARDIAN) trial in acute coronary syndromes

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https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Apoptosis in cardiac diseases--new opportunities for novel therapeutics for heart diseases

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7 January 2021

Recombinant human superoxide dismutase (h-SOD) fails to improve recovery of ventricular function in patients undergoing coronary angioplasty for acute myocardial infarction

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Studies on experimental myocardial infarction: dogs or baboons?

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https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Apoptosis in ischemic and reperfused rat myocardium

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Cytokines and the microcirculation in ischemia and reperfusion

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Role of Na(+)-H+ exchange on reperfusion related myocardial injury and arrhythmias in an open-chest swine model.

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Reperfusion injury induces apoptosis in rabbit cardiomyocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Direct measurement of myocardial free radical generation in an in vivo model: effects of postischemic reperfusion and treatment with human recombinant superoxide dismutase

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Future perspectives and potential implications of cardiac myocyte apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Clinical evaluation of leukocyte-depleted blood cardioplegia for pediatric open heart operation.

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Ischemia, reperfusion, and the determinants of tissue injury

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Abrupt reoxygenation of the anoxic potassium-arrested perfused rat heart: a study of myocardial enzyme release

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Caspase inhibition reduces myocyte cell death induced by myocardial ischemia and reperfusion in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

A Na+-H+ exchange inhibitor (SM-20550) protects from microvascular deterioration and myocardial injury after reperfusion

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Apoptosis in cardiac disease

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Canine myocardial reperfusion injury. Its reduction by the combined administration of superoxide dismutase and catalase.

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

The role of neutrophils in myocardial ischemia-reperfusion injury

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Apoptosis in heart failure: is there light at the end of the tunnel (TUNEL)?

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

The myocardial Na(+)-H(+) exchange: structure, regulation, and its role in heart disease

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Protective effect of the sodium/hydrogen exchange inhibitors during global low-flow ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Adenosine and cardioprotection in the diseased heart

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Time-dependent protection by Na+/H+ exchange inhibition in a regionally ischemic, reperfused porcine heart preparation with low residual blood flow

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Myocardial protection by Na(+)-H+ exchange inhibition in ischemic, reperfused porcine hearts

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Does reperfusion injury exist in humans?

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Pharmacology of the endothelium in ischemia-reperfusion and circulatory shock

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Biochemical changes of ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Dose-dependent reduction of myocardial infarct mass in rabbits by the NHE-1 inhibitor cariporide (HOE 642).

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Lethal Myocardial "Reperfusion Injury"

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Antiarrhythmic versus antifibrillatory actions: inference from experimental studies

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Adenosine as an adjunct to thrombolytic therapy for acute myocardial infarction: results of a multicenter, randomized, placebo-controlled trial: the Acute Myocardial Infarction STudy of ADenosine (AMISTAD) trial

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Evidence for a role of platelet activating factor in the pathogenesis of irreversible but not reversible myocardial injury after reperfusion in dogs

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Beneficial effects of intracoronary adenosine as an adjunct to primary angioplasty in acute myocardial infarction

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Species variation in the coronary collateral circulation during regional myocardial ischaemia: a critical determinant of the rate of evolution and extent of myocardial infarction.

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Alternatives for myocardial protection: adenosine-enhanced ischemic preconditioning

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Ischemic preconditioning limits infarct size following regional ischemia-reperfusion in in situ mouse hearts

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Sodium-hydrogen exchange inhibitors improve postischemic recovery of function in the perfused rabbit heart

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Caspases: killer proteases

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

"Apoptotic" myocytes in infarct area in rabbit hearts may be oncotic myocytes with DNA fragmentation: analysis by immunogold electron microscopy combined with In situ nick end-labeling

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Effect of caspase inhibitors on myocardial infarct size and myocyte DNA fragmentation in the ischemia-reperfused rat heart

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Reduction of reperfusion injury in the canine preparation by intracoronary adenosine: importance of the endothelium and the no-reflow phenomenon.

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Cardioprotection by Cu,Zn-superoxide dismutase is lost at high doses in the reoxygenated heart

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Na+/H+ exchangers of mammalian cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Mechanisms of myocardial reperfusion injury

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Adenosine: an effective and safe antiarrhythmic drug in pediatrics

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Myocardial protection by a cardioselective free radical scavenger

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Ischemic preconditioning attenuates ischemia/reperfusion-induced activation of caspases and subsequent cleavage of poly(ADP-ribose) polymerase in rat hearts in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Ischemic preconditioning decreases apoptosis in rat hearts in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Reduction of myocardial reperfusion injury by intravenous adenosine administered during the early reperfusion period.

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

"Reperfusion injury" by oxygen-derived free radicals? Effect of superoxide dismutase plus catalase, given at the time of reperfusion, on myocardial infarct size, contractile function, coronary microvasculature, and regional myocardial blood flow

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Oxygen radical scavenging agents as adjuvant therapy with tissue plasminogen activator in a canine model of coronary thrombolysis

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Animal models for protecting ischemic myocardium: results of the NHLBI Cooperative Study. Comparison of unconscious and conscious dog models.

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Matrix metalloproteinase inhibition attenuates early left ventricular enlargement after experimental myocardial infarction in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Reduction of the extent of ischemic myocardial injury by neutrophil depletion in the dog

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Cardioprotective effects of the Na(+)/H(+) exchange inhibitor cariporide in patients with acute anterior myocardial infarction undergoing direct PTCA

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

An association between collateral blood flow and myocardial viability in patients with recent myocardial infarction

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Reperfusion arrhythmias in the murine heart: their characteristics and alteration after ischemic preconditioning

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

The role of cell death in heart failure

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Na+/H+ exchanger activity does not contribute to protection by ischemic preconditioning in the isolated rat heart

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Reduction of experimental canine myocardial reperfusion injury by a monoclonal antibody (anti-Mo1, anti-CD11b) that inhibits leukocyte adhesion

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Cariporide, a highly selective Na+/H+ exchange inhibitor, suppresses the reperfusion-induced lethal arrhythmias and "overshoot" phenomenon of creatine phosphate in situ rat heart

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Characterisation and validation of a murine model of global ischaemia-reperfusion injury

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Myocardial cell protection : a challenging time for action and a challenging time for clinical research

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Inhibition of the sodium-hydrogen exchanger with cariporide to prevent myocardial infarction in high-risk ischemic situations. Main results of the GUARDIAN trial. Guard during ischemia against necrosis (GUARDIAN) Investigators

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Ischemic preconditioning in humans: models, mediators, and clinical relevance

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Studies on the role of sodium/hydrogen exchange system in myocardial ischemia-reperfusion injury

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

The Lambeth Conventions: guidelines for the study of arrhythmias in ischaemia infarction, and reperfusion

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Overexpression of human copper, zinc-superoxide dismutase (SOD1) prevents postischemic injury

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Failure of deferoxamine to reduce myocardial infarct size in a primate model of ischemia-reperfusion injury

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

The independent effects of oxygen radical scavengers on canine infarct size. Reduction by superoxide dismutase but not catalase

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Adenosine as an antiarrhythmic agent

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Attenuation of ischemia/reperfusion injury in rats by a caspase inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Apoptosis in relevant clinical situations: contribution of apoptosis in myocardial infarction

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Protecting the ischaemic and reperfused myocardium in acute myocardial infarction: distant dream or near reality?

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Targeted disruption of the mouse Sod I gene makes the hearts vulnerable to ischemic reperfusion injury

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Transgenic mice overexpressing glutathione peroxidase are resistant to myocardial ischemia reperfusion injury.

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Reperfusion induces myocardial apoptotic cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

Direct measurement of free radical generation following reperfusion of ischemic myocardium

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8719%2800%2900102-7

7 January 2021

10.1016/S1056-8719(00)00102-7

Identifiers

DOI

1 reference

31 July 2017

1 reference