(Q34127584)

English

Discovery of 1-(2,4-dichlorophenyl)-4-ethyl-5-(5-(2-(4-(trifluoromethyl)phenyl)ethynyl)thiophen-2-yl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide as a potential peripheral cannabinoid-1 receptor inverse agonist

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scholarly article

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Europe PubMed Central

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31 July 2017

Discovery of 1-(2,4-dichlorophenyl)-4-ethyl-5-(5-(2-(4-(trifluoromethyl)phenyl)ethynyl)thiophen-2-yl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide as a potential peripheral cannabinoid-1 receptor inverse agonist (English)

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

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cannabinoid receptor

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author name string

Ming-Shiu Hung

1

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31 July 2017

Chun-Ping Chang

2

1 reference

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31 July 2017

Ting-Chieh Li

3

1 reference

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31 July 2017

Teng-Kuang Yeh

4

1 reference

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31 July 2017

Jen-Shin Song

5

1 reference

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31 July 2017

Yinchiu Lin

6

1 reference

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31 July 2017

Chien-Huang Wu

7

1 reference

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31 July 2017

Po-Chu Kuo

8

1 reference

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31 July 2017

Prashanth K Amancha

9

1 reference

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31 July 2017

Ying-Chieh Wong

10

1 reference

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31 July 2017

Wen-Chi Hsiao

11

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31 July 2017

Yu-Sheng Chao

12

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31 July 2017

Kak-Shan Shia

13

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31 July 2017

publication date

1 September 2010

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31 July 2017

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31 July 2017

5

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31 July 2017

9

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31 July 2017

1439-1443

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PubMed publication ID

31 July 2017

Endocannabinoid signaling in the brain

1 reference

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International Union of Pharmacology. XXVII. Classification of cannabinoid receptors

1 reference

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Cultured rat microglial cells synthesize the endocannabinoid 2-arachidonylglycerol, which increases proliferation via a CB2 receptor-dependent mechanism

1 reference

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7 January 2021

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Molecular characterization of a peripheral receptor for cannabinoids

1 reference

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Cannabinoid receptor antagonists: pharmacological opportunities, clinical experience, and translational prognosis

1 reference

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7 January 2021

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Pharmacotherapy of obesity: currently marketed and upcoming agents

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Efficacy of sibutramine, orlistat and combination therapy on short-term weight management in obese patients

1 reference

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7 January 2021

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Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice

1 reference

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7 January 2021

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Conversion of 4-cyanomethyl-pyrazole-3-carboxamides into CB1 antagonists with lowered propensity to pass the blood-brain-barrier

1 reference

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7 January 2021

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The current status and future perspectives of studies of cannabinoid receptor 1 antagonists as anti-obesity agents

1 reference

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7 January 2021

based on heuristic

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Peripherally acting CB1-receptor antagonist: the relative importance of central and peripheral CB1 receptors in adiposity control

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Cannabinoid-1 receptor inverse agonists: current understanding of mechanism of action and unanswered questions

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Bioisosteric replacement of the pyrazole 5-aryl moiety of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A). A novel series of alkynylthiophenes as potent and selective cannabinoid-1 receptor

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000246

7 January 2021

based on heuristic

inferred from DOI database lookup

Palladium-catalyzed coupling reactions of bromothiophenes at the C-H bond adjacent to the sulfur atom with a new activator system, AgNO3/KF

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000246

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure-brain exposure relationships

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000246

7 January 2021

based on heuristic

inferred from DOI database lookup

Keynote review: Medicinal chemistry strategies to CB1 cannabinoid receptor antagonists

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000246

7 January 2021

based on heuristic

inferred from DOI database lookup

CB1 receptors in the preoptic anterior hypothalamus regulate WIN 55212-2 [(4,5-dihydro-2-methyl-4(4-morpholinylmethyl)-1-(1-naphthalenyl-carbonyl)-6H-pyrrolo[3,2,1ij]quinolin-6-one]-induced hypothermia.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000246

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1002/CMDC.201000246

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

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