(Q34128198)

31 July 2017

1 reference

title

Orexins and the treatment of obesity (English)

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31 July 2017

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Darren Smart

1

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31 July 2017

Andrea C Haynes

series ordinal

2

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31 July 2017

Gareth Williams

series ordinal

3

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31 July 2017

Jonathan R S Arch

series ordinal

4

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31 July 2017

language of work or name

English

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publication date

1 April 2002

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European Journal of Pharmacology

31 July 2017

published in

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31 July 2017

volume

440

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31 July 2017

issue

2-3

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31 July 2017

page(s)

199-212

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The contribution of increased thermogenesis to the effect of anorectic drugs on body composition in mice

31 July 2017

cites work

1 reference

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Orexin-A in the human brain and tumor tissues of ganglioneuroblastoma and neuroblastoma

7 January 2021

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Immunoreactive orexin-A in human plasma

7 January 2021

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Alteration of the expression of the hypocretin (orexin) gene by 2-deoxyglucose in the rat lateral hypothalamic area

7 January 2021

1 reference

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Hypothalamic hypocretin/orexin and neuropeptide Y: divergent interaction with energy depletion and leptin

7 January 2021

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Resistance to diet-induced obesity is associated with increased proopiomelanocortin mRNA and decreased neuropeptide Y mRNA in the hypothalamus

7 January 2021

1 reference

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Orexin-A, an hypothalamic peptide with analgesic properties

7 January 2021

1 reference

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Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat.

7 January 2021

1 reference

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Hypothalamic orexin expression: modulation by blood glucose and feeding.

7 January 2021

1 reference

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Down-regulation of orexin gene expression by severe obesity in the rats: studies in Zucker fatty and zucker diabetic fatty rats and effects of rosiglitazone.

7 January 2021

1 reference

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Food restriction selectively increases hypothalamic orexin-B levels in lactating rats.

7 January 2021

1 reference

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Hypoglycemia activates orexin neurons and selectively increases hypothalamic orexin-B levels: responses inhibited by feeding and possibly mediated by the nucleus of the solitary tract

7 January 2021

1 reference

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Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation

7 January 2021

1 reference

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Orexin A-like immunoreactivity in the rat brain

7 January 2021

1 reference

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Differential distribution of orexin-A and orexin-B immunoreactivity in the rat brain and spinal cord

7 January 2021

1 reference

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Structure-activity analysis of truncated orexin-A analogues at the orexin-1 receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Distribution of orexin/hypocretin in the rat median eminence and pituitary

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Effect of the antiobesity agent sibutramine in obese-diabetic ob/ob mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity

7 January 2021

1 reference

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Neuropeptide Y and energy balance: one way ahead for the treatment of obesity?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Hyperphagia induced by hypoglycemia in rats is independent of leptin and hypothalamic neuropeptide Y (NPY).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Evidence of NPY Y5 receptor involvement in food intake elicited by orexin A in sated rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Orexins: a role in medullary sympathetic outflow

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-1 (OX1) receptors, with downstream 5-HT2C receptor involvement

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Cloning of porcine prepro-orexin cDNA and effects of an intramuscular injection of synthetic porcine orexin-B on feed intake in young pigs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Changes in CSF hypocretin-1 (orexin A) levels in rats across 24 hours and in response to food deprivation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Morphological evidence for neural interactions between leptin and orexin in the hypothalamus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Immunohistochemical localization and biochemical characterization of hypocretin/orexin-related peptides in the central nervous system of the frog Rana ridibunda.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Effect of peripheral 2-DG on opioid and neuropeptide Y gene expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Opioids and food intake: distributed functional neural pathways?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Hypocretin receptor protein and mRNA expression in the dorsolateral pons of rats.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Insulin-induced hypoglycemia increases preprohypocretin (orexin) mRNA in the rat lateral hypothalamic area

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Orexinergic innervation of POMC-containing neurons in the rat arcuate nucleus.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Orexin A activates locus coeruleus cell firing and increases arousal in the rat.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Leptin receptor- and STAT3-immunoreactivities in hypocretin/orexin neurones of the lateral hypothalamus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Separate systems for serotonin and leptin in appetite control

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Behavioral satiety sequence (BSS) for the diagnosis of drug action on food intake.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Effects of single and chronic intracerebroventricular administration of the orexins on feeding in the rat

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

A selective orexin-1 receptor antagonist reduces food consumption in male and female rats.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Anorectic, thermogenic and anti-obesity activity of a selective orexin-1 receptor antagonist in ob/ob mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Gene expression and protein distribution of the orexin-1 receptor in the rat brain and spinal cord

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

High specificity of human orexin receptors for orexins over neuropeptide Y and other neuropeptides

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Induction of outward current by orexin-B in mouse peritoneal macrophages

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Effect of lateral cerebroventricular injection of the appetite-stimulating neuropeptide, orexin and neuropeptide Y, on the various behavioral activities of rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Both corticotropin releasing factor and neuropeptide Y are involved in the effect of orexin (hypocretin) on the food intake in rats.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Evidence that NPY Y1 receptors are involved in stimulation of feeding by orexins (hypocretins) in sated rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Effects of centrally administered orexin-B and orexin-A: a role for orexin-1 receptors in orexin-B-induced hyperactivity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Interacting appetite-regulating pathways in the hypothalamic regulation of body weight

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Sensitivity of orexin-A binding to phospholipase C inhibitors, neuropeptide Y, and secretin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Orexin synthesis and response in the gut.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Orexin-A and leptin change inversely in fasting non-obese subjects

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Solution structure of a new hypothalamic neuropeptide, human hypocretin-2/orexin-B

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Leptin receptor, NPY, POMC mRNA expression in the diet-induced obese mouse brain.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Orexin a preferentially excites glucose-sensitive neurons in the lateral hypothalamus of the rat in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Leptin regulation of prepro-orexin and orexin receptor mRNA levels in the hypothalamus.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Fall in blood glucose level precedes meal onset in free-feeding rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Differential distribution and regulation of OX1 and OX2 orexin/hypocretin receptor messenger RNA in the brain upon fasting.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Independent feeding and metabolic actions of orexins in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

The orexin OX1 receptor activates a novel Ca2+ influx pathway necessary for coupling to phospholipase C.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Differential expression of orexin receptors 1 and 2 in the rat brain.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Orexin A Stimulates Cortisol Secretion from Human Adrenocortical Cells through Activation of the Adenylate Cyclase-Dependent Signaling Cascade

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Hypocretin deficiency in familial symptomatic narcolepsy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Radioimmunoassay for orexin A

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Widespread distribution of orexin in rat brain and its regulation upon fasting

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Neurons containing orexin in the lateral hypothalamic area of the adult rat brain are activated by insulin-induced acute hypoglycemia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Hypocretin I in the lateral hypothalamus activates key feeding-regulatory brain sites

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Distribution of orexin neurons in the adult rat brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Orexins suppress catecholamine synthesis and secretion in cultured PC12 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Neuropeptide Y in central control of feeding and interactions with orexin and leptin.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Requirement of intact disulfide bonds in orexin-A-induced stimulation of gastric acid secretion that is mediated by OX1 receptor activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Neurons containing hypocretin (orexin) project to multiple neuronal systems

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Orexin A activates leptin-responsive neurons in the arcuate nucleus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Influence of topiramate in the regulation of energy balance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Dose-response effects of orexin-A on food intake and the behavioural satiety sequence in rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

SB-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-A in rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Melanin-concentrating hormone acutely stimulates feeding, but chronic administration has no effect on body weight

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Orexins and orexin receptors: implication in feeding behavior

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Melanin-concentrating hormone (MCH) antagonizes the effects of alpha-MSH and neuropeptide E-I on grooming and locomotor activities in the rat

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Effect of 2-mercaptoacetate and 2-deoxy-D-glucose administration on the expression of NPY, AGRP, POMC, MCH and hypocretin/orexin in the rat hypothalamus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Structure, tissue distribution, and pharmacological characterization of Xenopus orexins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Effects of leptin and orexin-A on food intake and feeding related hypothalamic neurons.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Viewpoint: are studies in genetically altered mice out of control?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Effects of Chronic Central Nervous System Administration of Agouti-Related Protein in Pair-Fed Animals

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Orexins: a new family of neuropeptides

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Characterization of recombinant human orexin receptor pharmacology in a Chinese hamster ovary cell-line using FLIPR

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

The hypocretins are weak agonists at recombinant human orexin-1 and orexin-2 receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

SB-334867-A: the first selective orexin-1 receptor antagonist

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Chronic cerebroventricular galanin does not induce sustained hyperphagia or obesity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

On the synthesis of orexin A: a novel one-step procedure to obtain peptides with two intramolecular disulphide bonds

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Orexins: effects on behavior and localisation of orexin receptor 2 messenger ribonucleic acid in the rat brainstem.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

The hypocretins: excitatory neuromodulatory peptides for multiple homeostatic systems, including sleep and feeding

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Feeding response to central orexins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Orexins/hypocretins: waking up the scientific world.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Distribution and quantification of immunoreactive orexin A in rat tissues.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Diurnal variation in orexin A immunoreactivity and prepro-orexin mRNA in the rat central nervous system.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Orexin A immunoreactivity and preproorexin mRNA in the brain of Zucker and WKY rats.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Characterization of melanin concentrating hormone and preproorexin expression in the murine hypothalamus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Distribution of orexin receptor mRNA in the rat brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Lateral hypothalamus: early developmental expression and response to hypocretin (orexin).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Modulation of the promoter region of prepro-hypocretin by alpha-interferon.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Synergistic interaction between CCK and leptin to regulate food intake

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

To eat or to sleep? Orexin in the regulation of feeding and wakefulness

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Food intake and the regulation of body weight.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Inhibition of food intake by central injection of anti-orexin antibody in fasted rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Down regulation of the prepro-orexin gene expression in genetically obese mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Postnatal development of orexin/hypocretin in rats.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Effects of food restriction on the hypothalamic prepro-orexin gene expression in genetically obese mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Chronic intracerebroventricular administration of orexin-A to rats increases food intake in daytime, but has no effect on body weight

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Orexin-induced food intake involves neuropeptide Y pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

Orexin-A regulates body temperature in coordination with arousal status.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2802%2901429-2

10.1016/S0014-2999(02)01429-2

7 January 2021

Identifiers

DOI

1 reference

release_liflwn5yb5copd4zn4mholzd7a

31 July 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/liflwn5yb5copd4zn4mholzd7a

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference