(Q34132179)

31 July 2017

title

Glucagon deficiency reduces hepatic glucose production and improves glucose tolerance in adult mice (English)

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31 July 2017

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Aidan S Hancock

1

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31 July 2017

Aiping Du

2

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31 July 2017

Jingxuan Liu

3

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31 July 2017

Mayumi Miller

4

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31 July 2017

Catherine L May

5

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31 July 2017

publication date

30 June 2010

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31 July 2017

published in

Molecular Endocrinology

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31 July 2017

volume

24

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31 July 2017

issue

8

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31 July 2017

page(s)

1605-1614

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Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity

31 July 2017

cites work

1 reference

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Mice deficient for glucagon gene-derived peptides display normoglycemia and hyperplasia of islet {alpha}-cells but not of intestinal L-cells

5 July 2018

1 reference

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Effects of insulin on the metabolic control of hepatic gluconeogenesis in vivo.

5 July 2018

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The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940466

CRTC2 (TORC2) contributes to the transcriptional response to fasting in the liver but is not required for the maintenance of glucose homeostasis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940466

Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein

5 July 2018

1 reference

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Targeted loss of Arx results in a developmental epilepsy mouse model and recapitulates the human phenotype in heterozygous females

5 July 2018

1 reference

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Making insulin-deficient type 1 diabetic rodents thrive without insulin

5 July 2018

1 reference

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Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression.

5 July 2018

1 reference

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Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940466

The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas

5 July 2018

1 reference

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Hepatic and glucagon-like peptide-1-mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors

5 July 2018

1 reference

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Opposing actions of Arx and Pax4 in endocrine pancreas development

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940466

Glucagon and regulation of glucose metabolism

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940466

Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940466

Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans

5 July 2018

1 reference

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The prohormone convertase enzyme 2 (PC2) is essential for processing pro-islet amyloid polypeptide at the NH2-terminal cleavage site

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940466

Molecular and cellular aspects of the glucagon receptor: role in diabetes and metabolism.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940466

Role of glucagon in maintenance of euglycemia in fed and fasted rats.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940466

Glucagon and the Insulin:Glucagon Ratio in Diabetes and Other Catabolic Illnesses

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940466

Somatostatin: Hypothalamic Inhibitor of the Endocrine Pancreas

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940466

Role of liver in pathophysiology of NIDDM

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940466

Evidence for an important role of glucagon in the regulation of hepatic glucose production in normal man.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940466

Effect of glucagon on glucose production during insulin deficiency in the dog

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940466

The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940466

Glucagon receptor signaling is essential for control of murine hepatocyte survival

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940466

Reduction in glucagon receptor expression by an antisense oligonucleotide ameliorates diabetic syndrome in db/db mice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940466

Autoregulation of endogenous glucose production during hyperglucagonemia

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940466

Glycemic control in mice with targeted disruption of the glucagon receptor gene

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940466

Incomplete processing of proinsulin to insulin accompanied by elevation of Des-31,32 proinsulin intermediates in islets of mice lacking active PC2.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940466

Physiological changes in circulating glucagon alter hepatic glucose disposition during portal glucose delivery.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940466

Glucagon: Role in the Hyperglycemia of Diabetes Mellitus

28 October 2018

1 reference

12 December 2020

Prevention of human diabetic ketoacidosis by somatostatin. Evidence for an essential role of glucagon

1 reference

12 December 2020

Hyperglucagonemia and its suppression. Importance in the metabolic control of diabetes

1 reference

12 December 2020

Possible mechanism by which somatostatin-induced glucagon suppression improves glucose tolerance during insulinopaenia in man

1 reference

12 December 2020

The role of poly(ADP-ribose) synthetase in the development of insulin-dependent diabetes and islet B-cell regeneration

1 reference

12 December 2020

Immunoneutralization of endogenous glucagon with monoclonal glucagon antibody normalizes hyperglycaemia in moderately streptozotocin-diabetic rats

1 reference

12 December 2020

Evidence for a Major Role for Glucagon in Regulation of Plasma Glucose in Conscious, Nondiabetic, and Alloxan-Induced Diabetic Rabbits

1 reference

12 December 2020

Glucagon receptor knockout mice display increased insulin sensitivity and impaired beta-cell function

1 reference

12 December 2020

Glucagon receptor knockout mice are resistant to diet-induced obesity and streptozotocin-mediated beta cell loss and hyperglycaemia

1 reference

12 December 2020

Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages

1 reference

12 December 2020

Lack of suppression of glucagon contributes to postprandial hyperglycemia in subjects with type 2 diabetes mellitus

1 reference

12 December 2020

Identifiers

DOI

10.1210/ME.2010-0120

1 reference

31 July 2017

1 reference

31 July 2017

1 reference