(Q34134991)

31 July 2017

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title

High-throughput high-performance liquid chromatography/mass spectrometry for modern drug discovery (English)

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high-performance liquid chromatography

31 July 2017

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Kyranos JN

1

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31 July 2017

Cai H

series ordinal

2

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31 July 2017

Wei D

series ordinal

3

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31 July 2017

Goetzinger WK

series ordinal

4

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31 July 2017

1 February 2001

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Current Opinion in Biotechnology

31 July 2017

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31 July 2017

12

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31 July 2017

1

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31 July 2017

105-111

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High-throughput and ultra-high-throughput screening: solution- and cell-based approaches

31 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

Applications of combinatorial technologies to drug discovery. 2. Combinatorial organic synthesis, library screening strategies, and future directions

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https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

Impact of mass spectrometry on combinatorial chemistry

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https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

Development of multichannel devices with an array of electrospray tips for high-throughput mass spectrometry.

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https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

Chromatographic aspects in high throughput liquid chromatography/mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

Analyses of compound libraries obtained by high-throughput parallel synthesis: strategy of quality control by high-performance liquid chromatography, mass spectrometry and nuclear magnetic resonance techniques.

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

High throughput liquid chromatography/mass spectrometric analyses using a novel multiplexed electrospray interface

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

High-speed screening of combinatorial libraries by gradient packed-column supercritical fluid chromatography

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

Packed column supercritical fluid chromatography/mass spectrometry for high-throughput analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

Packed column supercritical fluid chromatography/mass spectrometry for high-throughput analysis. Part 2.

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https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

Purification of combinatorial libraries

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https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

The development of a semi-preparatory scale supercritical-fluid chromatograph for high-throughput purification of 'combi-chem' libraries

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

High-throughput bioanalytical LC/MS/MS determination of benzodiazepines in human urine: 1000 samples per 12 hours.

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

Bioanalytical high-throughput selected reaction monitoring-LC/MS determination of selected estrogen receptor modulators in human plasma: 2000 samples/day

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

Demonstration of the capabilities of a parallel high performance liquid chromatography tandem mass spectrometry system for use in the analysis of drug discovery plasma samples

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

Direct plasma sample injection in multiple-component LC-MS-MS assays for high-throughput pharmacokinetic screening.

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

Direct determination of chlorpyrifos and its main metabolite 3,5, 6-trichloro-2-pyridinol in human serum and urine by coupled-column liquid chromatography/electrospray-tandem mass spectrometry.

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

Comparison of turbulent-flow chromatography with automated solid-phase extraction in 96-well plates and liquid-liquid extraction used as plasma sample preparation techniques for liquid chromatography-tandem mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

On-line sample preparation using restricted-access media in the analysis of the soy isoflavones, genistein and daidzein, in rat serum using liquid chromatography electrospray mass spectrometry.

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

A new approach to the effective preparation of plasma samples for rapid drug quantitation using on-line solid phase extraction mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

Direct analysis of plasma samples for drug discovery compounds using mixed-function column liquid chromatography tandem mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

High throughput on-line solid phase extraction/tandem mass spectrometric determination of paclitaxel in human serum

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

Ternary-column system for high-throughput direct-injection bioanalysis by liquid chromatography/tandem mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

High-throughput method development approaches for bioanalytical mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

Quantitative and qualitative determination of estrogen sulfates in human urine by liquid chromatography/tandem mass spectrometry using 96-well technology

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

High-throughput sample preparation and analysis using 96-well membrane solid-phase extraction and liquid chromatography-tandem mass spectrometry for the determination of steroids in human urine

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

'High throughput' solid-phase extraction technology and turbo ionspray LC-MS-MS applied to the determination of haloperidol in human plasma

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

Liquid chromatography/electrospray tandem mass spectrometry method for the quantitation of fosinoprilat in human serum using automated 96-well solid-phase extraction for sample preparation

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

Liquid-liquid extraction in the 96-well plate format with SRM LC/MS quantitative determination of methotrexate and its major metabolite in human plasma

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

Liquid chromatographic-electrospray tandem mass spectrometric method for the simultaneous quantitation of the prodrug fosinopril and the active drug fosinoprilat in human serum

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

Liquid-liquid extraction using 96-well plate format in conjunction with liquid chromatography/tandem mass spectrometry for quantitative determination of methylphenidate (Ritalin) in human plasma.

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

Higher throughput bioanalysis by automation of a protein precipitation assay using a 96-well format with detection by LC-MS/MS

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

Automated protein precipitation by filtration in the 96-well format

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

High-throughput screening in drug metabolism and pharmacokinetic support of drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

Determination of in vitro permeability of drug candidates through a caco-2 cell monolayer by liquid chromatography/tandem mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

High-throughput caco-2 cell permeability screening by cassette dosing and sample pooling approaches using direct injection/on-line guard cartridge extraction/tandem mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

Validation of higher-throughput high-performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry assays to conduct cytochrome P450s CYP2D6 and CYP3A4 enzyme inhibition studies in human liver microsomes

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

High-throughput cytochrome P450 (CYP) inhibition screening via cassette probe-dosing strategy. I. Development of direct injection/on-line guard cartridge extraction/tandem mass spectrometry for the simultaneous detection of CYP probe substrates and

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

Quantification and rapid metabolite identification in drug discovery using API time-of-flight LC/MS.

1 reference

https://api.crossref.org/works/10.1016%2FS0958-1669%2800%2900176-2

7 January 2021

10.1016/S0958-1669(00)00176-2

Identifiers

DOI

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31 July 2017

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