(Q34138180)

31 July 2017

title

Adaptive design clinical trials: Methodology, challenges and prospect (English)

1 reference

31 July 2017

Rajiv Mahajan

1

1 reference

31 July 2017

Kapil Gupta

series ordinal

2

1 reference

31 July 2017

language of work or name

English

0 references

publication date

1 August 2010

1 reference

full work available at URL

31 July 2017

https://europepmc.org/articles/pmc2941608

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20927243

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20927243/?tool=EBI

28 July 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20927243

https://europepmc.org/articles/PMC2941608

28 July 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20927243

Indian Journal of Pharmacology

28 July 2024

published in

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31 July 2017

volume

42

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31 July 2017

issue

4

1 reference

31 July 2017

page(s)

201-207

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Barriers and opportunities for implementation of adaptive designs in pharmaceutical product development

31 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2941608

A regulatory view of adaptive trial design

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2941608

Adaptive clinical trials: progress and challenges

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2941608

Combining proof-of-concept with dose-finding: utilization of adaptive designs in migraine clinical trials

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2941608

Adaptive design methods in clinical trials - a review

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2941608

The FDA critical path initiative and its influence on new drug development.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2941608

Adaptive group sequential test for clinical trials with changing patient population

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2941608

Adaptive statistical analysis following sample size modification based on interim review of effect size

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2941608

Meta-analyses and adaptive group sequential designs in the clinical development process

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2941608

The advantages and disadvantages of adaptive designs for clinical trials

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2941608

Approximately optimal one-parameter boundaries for group sequential trials.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2941608

Approaches to evaluation of treatment effect in randomized clinical trials with genomic subset

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2941608

FDA introductory comments: clinical studies design and evaluation issues.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2941608

Group sequential, sample size re-estimation and two-stage adaptive designs in clinical trials: a comparison

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2941608

An adaptive dose-finding design incorporating both toxicity and efficacy.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2941608

Drop-the-losers design: normal case.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2941608

Statistical consideration of adaptive methods in clinical development.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2941608

Optimal adaptive designs for binary response trials.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2941608

On sample size and inference for two-stage adaptive designs

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2941608

Continual reassessment method: a likelihood approach.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2941608

An Adaptive Group Sequential Design for Phase II/III Clinical Trials that Select a Single Treatment From Several

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2941608

Inference for clinical trials with some protocol amendments

28 October 2018

1 reference

12 December 2020

Adaptive trials receive boost

1 reference

12 December 2020

Combining different phases in the development of medical treatments within a single trial

1 reference

12 December 2020

On Two-stage Seamless Adaptive Design in Clinical Trials

1 reference

12 December 2020

Adaptive designs in clinical drug development--an Executive Summary of the PhRMA Working Group

1 reference

12 December 2020

A hybrid Bayesian adaptive design for dose response trials.

1 reference

12 December 2020

Statistical analysis for two-stage seamless design with different study endpoints

1 reference

12 December 2020

Estimating a treatment effect in survival studies in which patients switch treatment

1 reference

12 December 2020

Annual Review of Medicine

4

1

Woodcock

2008

1 reference

Crossref

DOI

10.4103/0253-7613.68417

https://api.crossref.org/works/10.4103/0253-7613.68417

Nature Reviews Drug Discovery

28 July 2024

51

345

Jones

2010

1 reference

Crossref

DOI

10.4103/0253-7613.68417

https://api.crossref.org/works/10.4103/0253-7613.68417

28 July 2024

Identifiers

DOI

10.4103/0253-7613.68417

1 reference

31 July 2017

1 reference

31 July 2017

1 reference