(Q34142384)

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Diindolylmethane suppresses ovarian cancer growth and potentiates the effect of cisplatin in tumor mouse model by targeting signal transducer and activator of transcription 3 (STAT3).

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Europe PubMed Central

PubMed publication ID

31 July 2017

Diindolylmethane suppresses ovarian cancer growth and potentiates the effect of cisplatin in tumor mouse model by targeting signal transducer and activator of transcription 3 (STAT3). (English)

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

1 reference

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author name string

Prabodh K Kandala

1

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Sanjay K Srivastava

2

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Europe PubMed Central

PubMed publication ID

31 July 2017

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26 January 2012

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Europe PubMed Central

PubMed publication ID

31 July 2017

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

10

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Europe PubMed Central

PubMed publication ID

31 July 2017

9

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Europe PubMed Central

PubMed publication ID

31 July 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3298725/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Attenuation of multi-targeted proliferation-linked signaling by 3,3'-diindolylmethane (DIM): from bench to clinic

1 reference

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Pancreatic tumor suppression by benzyl isothiocyanate is associated with inhibition of PI3K/AKT/FOXO pathway

1 reference

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1 reference

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BRCA1-IRIS Overexpression Promotes Cisplatin Resistance in Ovarian Cancer Cells

1 reference

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A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer

1 reference

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Cancer statistics, 2010

1 reference

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1 reference

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Benzyl isothiocyanate-mediated inhibition of histone deacetylase leads to NF-kappaB turnoff in human pancreatic carcinoma cells

1 reference

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Activation of checkpoint kinase 2 by 3,3'-diindolylmethane is required for causing G2/M cell cycle arrest in human ovarian cancer cells

1 reference

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Sorafenib inhibits STAT3 activation to enhance TRAIL-mediated apoptosis in human pancreatic cancer cells

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1 reference

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Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia.

1 reference

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1 reference

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RETRACTED: 3,3'-Diindolylmethane enhances chemosensitivity of multiple chemotherapeutic agents in pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298725

5 July 2018

The role of STAT-3 in the induction of apoptosis in pancreatic cancer cells by benzyl isothiocyanate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298725

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Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial-mesenchymal transition in ovarian carcinomas.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298725

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Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3'-diindolylmethane in healthy subjects

1 reference

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Green tea catechins inhibit angiogenesis through suppression of STAT3 activation

1 reference

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NCX-4016, a nitro-derivative of aspirin, inhibits EGFR and STAT3 signaling and modulates Bcl-2 proteins in cisplatin-resistant human ovarian cancer cells and xenografts

1 reference

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Dose translation from animal to human studies revisited

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The role of constitutively active signal transducer and activator of transcription 3 in ovarian tumorigenesis and prognosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298725

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Signal transducers and activators of transcription 3 pathway activation in drug-resistant ovarian cancer

1 reference

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Intrinsic cisplatin resistance in lung and ovarian cancer cells propagating in medium acutely depleted of folate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298725

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Gene expression profiling revealed survivin as a target of 3,3'-diindolylmethane-induced cell growth inhibition and apoptosis in breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298725

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Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298725

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STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298725

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Inhibition of nuclear translocation of nuclear factor-{kappa}B contributes to 3,3'-diindolylmethane-induced apoptosis in breast cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298725

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Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

1 reference

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Reproductive hormone-induced, STAT3-mediated interleukin 6 action in normal and malignant human ovarian surface epithelial cells

1 reference

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Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention

1 reference

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Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298725

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Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298725

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STAT proteins and transcriptional responses to extracellular signals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298725

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STATs in oncogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298725

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The role of STATs in transcriptional control and their impact on cellular function

1 reference

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Stat3 as an oncogene

1 reference

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Cisplatin-induced renal toxicity: possible reversal by N-acetylcysteine treatment

1 reference

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Prospective on ovarian cancer: why prevent?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298725

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Cisplatin as first-line therapy for metastatic breast cancer

1 reference

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Acquired cisplatin resistance in human ovarian cancer cells is associated with enhanced repair of cisplatin-DNA lesions and reduced drug accumulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298725

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Oligomerization of indole-3-carbinol in aqueous acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298725

5 July 2018

The Jak-STAT pathway stimulated by interleukin 6.

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-10-9

21 January 2018

Constitutive activation of stat 3 oncogene product in human ovarian carcinoma cells.

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-10-9

21 January 2018

Effect of boiling on the content of ascorbigen, indole-3-carbinol, indole-3-acetonitrile, and 3,3'-diindolylmethane in fermented cabbage.

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-10-9

21 January 2018

3,3'-Diindolylmethane inhibits angiogenesis and the growth of transplantable human breast carcinoma in athymic mice

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-10-9

21 January 2018

Capsiate, a nonpungent capsaicin-like compound, inhibits angiogenesis and vascular permeability via a direct inhibition of Src kinase activity.

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-10-9

21 January 2018

Selective inhibition of STAT3 induces apoptosis and G(1) cell cycle arrest in ALK-positive anaplastic large cell lymphoma

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-10-9

21 January 2018

A meta-analysis of the efficacy of intraperitoneal cisplatin for the front-line treatment of ovarian cancer.

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-10-9

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Diet and ovarian cancer risk: A case-control study in Italy

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-10-9

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Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22280969

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human ovarian surface epithelium in primary culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/22280969

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

STAT3 and hypoxia induced proteins--HIF-1alpha, EPO and EPOR in relation with Bax and Bcl-xL in nodal metastases of ductal breast cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/22280969

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intraperitoneal cisplatin therapy in ovarian cancer: comparison with standard intravenous carboplatin and paclitaxel

1 reference

https://pubmed.ncbi.nlm.nih.gov/22280969

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1741-7015-10-9

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

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PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

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