(Q34149624)

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NMDA receptor antagonists ketamine and PCP have direct effects on the dopamine D(2) and serotonin 5-HT(2)receptors-implications for models of schizophrenia

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scholarly article

1 reference

Europe PubMed Central

31 July 2017

NMDA receptor antagonists ketamine and PCP have direct effects on the dopamine D(2) and serotonin 5-HT(2)receptors-implications for models of schizophrenia (English)

1 reference

Europe PubMed Central

31 July 2017

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1

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Europe PubMed Central

31 July 2017

author name string

Seeman P

2

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Europe PubMed Central

31 July 2017

language of work or name

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publication date

1 January 2002

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Europe PubMed Central

31 July 2017

Molecular Psychiatry

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Europe PubMed Central

31 July 2017

7

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Europe PubMed Central

31 July 2017

8

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Europe PubMed Central

31 July 2017

837-844

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Europe PubMed Central

31 July 2017

https://scigraph.springernature.com/pub.10.1038/sj.mp.4001093

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Dopamine as the wind of the psychotic fire: new evidence from brain imaging studies

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Schizophrenia: more dopamine, more D2 receptors

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Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia

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Interactions between glutamatergic and monoaminergic systems within the basal ganglia-implications for schizophrenia and Parkinson's disease

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The neuropsychopharmacology of phencyclidine: from NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia

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The effect of ketamine upon norepinephrine and dopamine levels in rabbit brain parts

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PCP site 2: a high affinity MK-801-insensitive phencyclidine binding site

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Ketamine inhibits monoamine transporters expressed in human embryonic kidney 293 cells

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The functional state of the dopamine receptor in the anterior pituitary is in the high affinity form.

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Dopamine receptor parameters detected by [3H]spiperone depend on tissue concentration: analysis and examples.

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Characterization of the human dopamine D3 receptor expressed in transfected cell lines

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Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins

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Agonist action at D2(long) dopamine receptors: ligand binding and functional assays

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Ketamine has equal affinity for NMDA receptors and the high-affinity state of the dopamine D2 receptor

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Ketamine stereoselectively inhibits rat dopamine transporter

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Inhibition of neuronal 5-HT uptake by ketamine, but not halothane, involves disruption of substrate recognition by the transporter.

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Psychedelic effects of ketamine in healthy volunteers: relationship to steady-state plasma concentrations

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Pharmacokinetics and pharmacodynamics of ketamine enantiomers in surgical patients using a stereoselective analytical method.

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Ketamine infusions: pharmacokinetics and clinical effects

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Oral ketamine is antinociceptive in the rat formalin test: role of the metabolite, norketamine.

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Schizophrenia: a subcortical neurotransmitter imbalance syndrome?

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Stereoselective interaction of ketamine with recombinant mu, kappa, and delta opioid receptors expressed in Chinese hamster ovary cells.

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Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats

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Using an animal model of deficient sensorimotor gating to study the pathophysiology and new treatments of schizophrenia

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Seroquel, clozapine and chlorpromazine restore sensorimotor gating in ketamine-treated rats.

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Modulation of MK-801 response by dopaminergic agents in mice

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Comparison of haloperidol and chlorpromazine in the treatment of phencyclidine psychosis

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Comparison of chlorpromazine, haloperidol and pimozide in the treatment of phencyclidine psychosis: DA-2 receptor specificity

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Treatment of phenylcyclohexylpyrrolidine (PHP) psychosis with haloperidol

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Atypical antipsychotics in the treatment of schizophrenia: systematic overview and meta-regression analysis

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Involvement of serotonin 2A receptors in phencyclidine-induced disruption of prepulse inhibition of the acoustic startle in rats.

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M100907, a selective 5-HT2A receptor antagonist and a potential antipsychotic drug, facilitates N-methyl-D-aspartate-receptor mediated neurotransmission in the rat medial prefrontal cortical neurons in vitro.

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M100907 and clozapine, but not haloperidol or raclopride, prevent phencyclidine-induced blockade of NMDA responses in pyramidal neurons of the rat medial prefrontal cortical slice.

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Antagonism of phencyclidine-induced hyperactivity by glycine in mice.

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Interactive effects of subanesthetic ketamine and haloperidol in healthy humans.

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M100907, a serotonin 5-HT2A receptor antagonist and putative antipsychotic, blocks dizocilpine-induced prepulse inhibition deficits in Sprague-Dawley and Wistar rats

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Network interactions in schizophrenia - therapeutic implications

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7 January 2021

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Protection with phencyclidine against inactivation of 5-HT2 receptors by sulfhydryl-modifying reagents

1 reference

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based on heuristic

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The human dopamine D2(Longer) receptor has a high-affinity state and inhibits adenylyl cyclase

1 reference

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Dependence of dopamine receptor conversion from agonist high- to low-affinity state on temperature and sodium ions

1 reference

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Schizophrenia and glutamatergic transmission

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Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex.

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Contrasting mechanisms of action and sensitivity to antipsychotics of phencyclidine versus amphetamine: importance of nucleus accumbens 5-HT2Asites for PCP-induced locomotion in the rat

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The selective 5-HT2A receptor antagonist MDL 100,907 counteracts the psychomotor stimulation ensuing manipulations with monoaminergic, glutamatergic or muscarinic neurotransmission in the mouse--implications for psychosis

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SCH 23390 equivalently, but YM-09151-2 differentially reduces the stimulant effects of methamphetamine, MK-801 and ketamine: assessment by discrete shuttle avoidance in mice.

1 reference

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Dopamine receptor antagonists block amphetamine and phencyclidine-induced motor stimulation in rats

1 reference

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Phencyclidine-induced head-twitch responses as 5-HT2 receptor-mediated behavior in rats

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inferred from DOI database lookup

Identifiers

10.1038/SJ.MP.4001093

1 reference

Europe PubMed Central

31 July 2017

1 reference

Europe PubMed Central

31 July 2017

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